2000
DOI: 10.1161/01.str.31.3.774
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The Symptomatic Carotid Plaque

Abstract: Background-The natural histories of equally severe symptomatic and asymptomatic carotid stenoses are very different, which suggests dichotomy in plaque behavior. The vascular biology of the symptomatic carotid plaque is presented in this review. Summary of Review-Histology studies comparing asymptomatic and symptomatic plaques were identified from MEDLINE. Reports in which stenosis severity was not stated or not similar for symptomatic and asymptomatic patients were excluded. In vitro studies and reports from … Show more

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Cited by 384 publications
(297 citation statements)
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References 96 publications
(77 reference statements)
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“…Enquanto é provável que poucas formas de acidente vascular cerebral relacionado à estenose carótida extracraniana ocorram por hipoperfusão 11 , na maioria dos casos, o que ocorre é embolização de uma placa aterosclerótica ou oclusão aguda da carótida e propagação do trombo distalmente 12 .…”
Section: Estenose De Carótida Extracranianaunclassified
“…Enquanto é provável que poucas formas de acidente vascular cerebral relacionado à estenose carótida extracraniana ocorram por hipoperfusão 11 , na maioria dos casos, o que ocorre é embolização de uma placa aterosclerótica ou oclusão aguda da carótida e propagação do trombo distalmente 12 .…”
Section: Estenose De Carótida Extracranianaunclassified
“…The importance of carotid atherosclerosis and related thromboembolic occlusion of a large artery tributary of the brain in the pathogenesis of ischemia and cerebral infarction has been acknowledged for many years [1][2][3][4]. Although the grade of stenosis due to a plaque encroaching the lumen constitutes the major criterion to identify subgroups of patients at high risk of stroke [5,6], results from several studies suggest that plaque rupture and thrombosis represent the most important factor correlated with the onset of symptoms [1,3].…”
Section: Introductionmentioning
confidence: 99%
“…Rupture of atherosclerotic plaques is crucial in the pathogenesis of acute coronary syndromes and strokes [20,21]. Interactions, within the ICA stenosing plaque, between connective tissue and the cells embedded into the fibrous cap overlying the inner core appear to determine the history of the ICA stenosis: plaque rupture or ulceration, intraplaque haemorrhage and luminal thrombosis are recognized causes of stroke [20,21].…”
Section: Introductionmentioning
confidence: 99%
“…Interactions, within the ICA stenosing plaque, between connective tissue and the cells embedded into the fibrous cap overlying the inner core appear to determine the history of the ICA stenosis: plaque rupture or ulceration, intraplaque haemorrhage and luminal thrombosis are recognized causes of stroke [20,21]. Specific markers to identify in vivo ruptured plaques, or plaques prone to rupture, are not available.…”
Section: Introductionmentioning
confidence: 99%