The Sympathomimetic Effects of SKF-385 on Blood Pressure in Dog

Toda, Noboru; Yamawaki, Tadaaki; Misu, Yoshimi

doi:10.1254/jjp.12.166

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…The lesser depletion of noradrenaline or serotonin by 10-MD than by reserpine (10,16,17) (18)(19)(20). In addition, the pressor response of the dogs to SKF-385 has been shown to relate with the endogenous noradrenaline (21). Despite the possible manifestation of the sympathetic effects the administration of SKF 385 did not affect the ear temperature, but elevated the rectal temperature moderately.…”

Section: Discussionmentioning

confidence: 99%

Effects of 10-Methoxydeserpidine and Reserpine on the Skin and Rectal Temperature in Rabbits

Toda

Shimamoto

Fujiwara

1964

Japanese Journal of Pharmacology

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Although the peripheral effects of reserpine are generally accepted, there is evidence to support the central action on the adrenal medulla (1)(2)(3)(4)(5). No depletion of tissue nor adrenaline by 10-methoxydeserpidine (10-MD) has been reported in mice by Leroy and Schaepdryver (6). However, Higuchi et al. (7) have shown that the intravenous injec tion of 10-MD in rabbits depletes considerably the content of noradrenaline in the brain cortex, brain stem and heart, and of adrenaline in the adrenal medulla without mani festing sedation or diarrhea.10-MD has recently been used clinically for the essential hypertension. Episode of the side effect that hyperemia and warm sensation of the face and neck manifest in some patients several hours after the oral administration has been reported (8). No such side effect has hitherto been reported in the case of reserpine. Therefore, the current report deals firstly with elucidation of action mechanism of the hyperemia and warm sensation in the face and neck caused by 10-MD, and secondarily with the phar macological difference between reserpine and 10-MD. The results in the present ex periments have shown that though reserpine produces a marked elevation of the ear temperature followed by a steady fall of the rectal temperature , 10-MD elicits a similar elevation of the ear temperature attended with no change in the rectal temperature in rabbits. METHODSThe effects of the intravenous injection of reserpine and 10-MD on the ear, thigh and rectal temperature, the spontaneous electroencephalogram (EEG), the electrocardio gram (ECG), the respiration and the content of adrenaline, noradrenaline and serotonin of the various tissues were investigated in albino rabbits, weighing 2.0 to 2.5 kg of either sex, at the room temperature of 24±0.3°C. The animals anesthetized at the stage III (plane 2 or 3) with ether were fixed on the stereotaxic instrument in an abdominal position. The surgical procedures were performed during the anesthesia. The full awaking on the EEG pattern was usually obtained about one hour after the termina tion of ether inhalation. The experiments were commenced after the stabilization of

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Section: Discussionmentioning

confidence: 99%