The sympathogenic biochemical trigger mechanism of angina pectoris

Comparison between Antioxidant Effect of Vitamin-C Alone and its Combination to Vitamin-E in Long Evans Norwegian Rat

“…The increased enzyme levels were associated with severe degree of microscopical changes supporting myocardial damage. These are also in well agreement with others 4,[8][9][10] . Vitamin-C has no significant effect on normal myocardium which was evidenced by the fact that there were no rise in serum AST and LDH levels like adrenaline alone treated group (Gr-II).…”

Civilization-Induced Neurogenic Degenerative Heart Disease

“…Thus, in the presence of coronary athero sclerosis and/or intramural arteriolar sclerosis (16), the metabolic vulnerability of the heart muscle to hypoxiating sympalhogenic catecholamine action becomes extreme, and any catecholamineliberating sympathetic reflex stimulation, as during physical effort or emotional stress, can suffice to provoke potentially fatal myo cardial injury; this all the more if oxygen-preserving sympathoinhibitory and cholinergic counterregulation happens to be insuf ficient. The syndrome of angina pectoris, and probably a large number of non-occlusive myocardial infarctions are, in all likeli hood, caused by the hypoxiating and ultimately necrotizing effect of acute sympathogenic and adrenal medullary catecholamine in fluxes into poorly vascularized areas of the myocardium (25). It is significant that in patients with angina pectoris, one of the most common "diseases of civilization", the physiological, exer cise-, emotion-, and nicotine-induced discharges of catecholamines and corresponding free fatty acids into the blood circulation have been found abnormally exaggerated (8, 14a, 27, 35, 36).…”

“…3). Apart of its well-known sympathogenic cardiovascular manifestations (25), emotional stress has been shown more recently to be accompanied by an increase of the catecholamines in blood (30) and urine (2,0,7,20), and by a rise of the most sensitive metabolic indicator of augmented cat echolamine action, namely, the blood level of free fatty acids (2,12). Fig.…”

Myocardial Metabolic Vulnerability Key Problem in Pluricausal, ‘Coronary’ Heart Disease

“…Under certain stressful circumstances, the myocardial electrolyte metabolism is further adversely affected by adreno cortical hyperactivity. The extensive experimental and clinical literature on these subjects has been reviewed elsewhere [ [22]. The classical acute manifestation of a catecholamine-induced, hypoxiating discrepancy between myocardial oxygen supply and demand is the anginal attack.…”

“…The classical acute manifestation of a catecholamine-induced, hypoxiating discrepancy between myocardial oxygen supply and demand is the anginal attack. It is associated with a marked eleva tion of the plasma catecholamine level [22,26] and an abnormally high content of lactic acid in the blood of the coronary sinus |7|. Advanced atherosclerosis of major coronary arteries is found with great regularity in patients with angina pectoris both at autopsy and by coronary angiography.…”