The symbiotic effect of osteoinductive extracellular vesicles and mineralized microenvironment on osteogenesis
Ketki Holkar,
Vaijayanti Kale,
Prasad Pethe
et al.
Abstract:The increasing prevalence of bone‐related diseases has raised concern about the need for an osteoinductive and mechanically stronger scaffold‐based bone tissue engineering (BTE) alternative. A mineralized microenvironment, similar to the native bone microenvironment, is required in the scaffold to recruit and differentiate local mesenchymal stem cells at the bone defect site. Further, extracellular vesicles (EVs), pre‐osteoblasts' secretome, contain osteoinductive cargo and have recently been exploited in bone… Show more
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