The Sylvian fissure in schizophrenia. A quantitative post-mortem study

Falkai, P.; Bogerts, B.; Greve, B.; Pfeiffer, U.; Machus, B.

doi:10.1016/0920-9964(93)90260-p

Cited by 29 publications

(37 citation statements)

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“…In post-mortem brains of 35 schizophrenic patients and 33 matched non psychiatric control subjects, Falkai et al, noted that the SF showed a significantly reduced length of the left SF (-16%, p < 0.0001) compared to the control subjects, while the right SF length was unchanged. The SF asymmetry (left/right ratio) was more reduced in male schizophrenics (-24%, p less than 0.001) than in female patients (-16%, p less than 0.03) [19]. This finding is consistent with several post-mortem and MRI studies showing left temporal lobe pathology or opioid abuse [20,21].…”

Section: Discussionsupporting

confidence: 82%

Morphometry, Asymmetry and Variations of the Sylvian Fissure and Sulci Bordering and Within the Pars Triangularis and Pars Operculum: An Autopsy Study

Idowu

Soyemi

Atobatele

2014

JCDR

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Objective: Speech and Language, one of the most lateralized of all cerebral functions is located within the pars opercularis (PO) and pars triangularis (PT). There is also inter-hemispheric variability of the sulcal contours bordering these areas. The study was undertaken to note the morphometry, asymmetry and variations of the Sylvian fissure (SF), and the sulci bordering and within the PO and PT. Materials and Methods:An adult autopsy cadaveric study was carried. The measurements made amongst others, included fronto-occipital cerebral length, cerebral width, Sylvian fissure length, and anterior Sylvian point (ASP) to inferior Rolandic point distance. The PT and PO were also studied.

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Section: Discussionsupporting

confidence: 82%

Morphometry, Asymmetry and Variations of the Sylvian Fissure and Sulci Bordering and Within the Pars Triangularis and Pars Operculum: An Autopsy Study

Idowu

Soyemi

Atobatele

2014

JCDR

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“…Moreover, the anterior-to-posterior extent of the aPO was similar in both hemispheres (anterior border, CS-SF: y ϭ Ϫ10.1 Ϯ 1.0 mm, left; y ϭ Ϫ10.2 Ϯ 0.6 mm, right; posterior border, PSS-SF: y ϭ Ϫ20.3 Ϯ 1.1 mm, left; y ϭ Ϫ19.7 Ϯ 1.1 mm, right). The posterior limit of SF lay about 8 mm further posterior in the left than in the right hemisphere (y ϭ Ϫ47.2 Ϯ 1.4 vs. Ϫ39.4 Ϯ 1.1 mm, P Ͻ 0.0001), in accordance with previous reports (Falkai et al 1992;Steinmetz et al 1989). This resulted in a larger left pPO area (9.13 Ϯ 0.41 vs. 7.04 Ϯ 0.41 cm 2 , P Ͻ 0.005), detected in 14 of 16 subjects.…”

Section: Auditory Lateralization Handedness and Opercular Morphometrysupporting

confidence: 91%

Structural and Functional Asymmetry in the Human Parietal Opercular Cortex

Jung¹,

Baumgärtner²,

Stoeter³

et al. 2009

Journal of Neurophysiology

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Jung P, Baumgä rtner U, Stoeter P, Treede R-D. Structural and functional asymmetry in the human parietal opercular cortex. J Neurophysiol 101: 3246 -3257, 2009. First published April 8, 2009 doi:10.1152/jn.91264.2008. In this combined electroencephalographic and magnetic resonance imaging (MRI) study, the asymmetry of functional and structural measures in the human parietal operculum (PO) were investigated. Median nerve somatosensory evoked potential recordings showed maximum scalp potentials over contralateral (N80, N110) and ipsilateral (N100, N130) temporal electrode positions. In accordance, MRI-coregistered source analysis revealed two electrical sources in the contralateral (N80, N110) and two in the ipsilateral (N100, N130) PO. The dipole orientations of the contraand ipsilateral sources with earlier peak activation, N80 and N100, were more tangential than those of the later peaking N110 and N130 sources. The most prominent contralateral N110 source exhibited pronounced left lateralized dipole strengths in the 80-to 120-ms latency range, in contrast to symmetrical N80 and ipsilateral source responses. The asymmetry of the N110 source activity explained both the asymmetry of N110 and N100 scalp potentials. Morphometric analysis demonstrated no interhemispheric differences in the sizes of the anterior PO (aPO), containing the cytoarchitectonic areas OP3 and OP4, but left lateralized sizes of the posterior PO (pPO), which encompasses the anatomically defined areas OP1 and OP2. The N110 source was located in the pPO and its asymmetry was significantly correlated with the structural pPO asymmetry but not with handedness and auditory lateralization. Thus both structural and functional asymmetries exist in the human PO and they are closely related to each other but not to measures of brain asymmetry in other functional systems, i.e., auditory lateralization and handedness.

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“…The abnormalities in hemispheric asymmetry in schizophrenia include 1) a lack of normal asymmetry in prefrontal and occipitoparietal volumes (29); 2) less than normal asymmetry in the temporal lobes (30), the planum temporale cortex (31), the lateral (sylvian) fissure (32,33), and the frontal and occipital lobes (34,35); and 3) a reversal of normal asymmetry in the volumes of the occipital (36,37) and frontal (36) lobes, posterior superior temporal gyrus (38), and inferior parietal lobule (39) and in planum temporal surface area (40,41).…”

Section: Discussionmentioning

confidence: 99%