The switchable integrin adhesome

Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility

“…Therefore, the observed effect of matrix elasticity on HSPCs is mediated by integrins, which mechanically couple the cells to the extracellular matrix. It is well known for other cell types that integrins are not only involved in sensing the chemical but also the physical environment of a cell (Bershadsky et al, 2003;Schwarz et al, 2006;Zaidel-Bar and Geiger, 2010;Zamir and Geiger, 2001). In conclusion, we think that HSPCs, similar to other cell types, sense the chemical and physical properties (including substrate elasticity) of their environment through integrin receptors and their associated proteins.…”

Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix

“…Integrin signaling depends on the allosteric behavior of the receptors, their ability to concentrate into adhesion zones, and the recruitment to these zones of numerous other "adhesome" components to form complex integrin-based cell adhesions (Zaidel-Bar et al 2007;Zaidel-Bar and Geiger 2010). Many adhesome components are enzymes that interact with classic signaling pathways.…”

Rapid Reversible Photoswitching of Integrin‐Mediated Adhesion at the Single‐Cell Level

“…[ 1,2 ] The involved processes are highly dynamic and exhibit remarkable switchability, which enable cell migration and differential cell-matrix adhesion. [ 3,4 ] Being able to dynamically control adhesion by switching surface properties between adhesion promoting and impeding conditions is of supreme relevance for the development of novel biomaterials, having applications in tissue engineering and implant design. In order to create such dynamic adhesion environments, unidirectional, and irreversible switching of integrin-mediated adhesion has been achieved by light-triggered activation of caged molecules and by electrochemical switching.…”