The Swelling &amp; Water Uptake of Tablets III: Moisture Sorption Behavior of Tablet Disintegrants

Faroongsarng, Damrongsak; Peck, Garnet E.

doi:10.3109/03639049409038331

Cited by 35 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For Avicel PH 102, which is known to exhibit a type II isotherm, the W m values obtained in our experiment are similar to those found in the literature. [15][16][17][18] High values of W m obtained in these studies indicate that more than one layer of water molecules is sorbed on compounds at declared experimental conditions. Since higher values of the constant C reflect the suitability of the model used, 4,22) the lower values of C obtained in the case of all excipients, except Avicel PH 102, mean that their isotherms fit more to a type III isotherm category.…”

Section: Resultsmentioning

confidence: 83%

“…[10][11][12][13] Due to the above mentioned reasons the GAB isotherm has been recommended as the fundamental equation for water sorption by foods. 14) With regard to pharmaceutical additives, there is not much information in the literature except for cellulose, starch and their derivatives, [15][16][17][18] so the main objective of our work was to evaluate the sorption behaviour of several pharmaceutically important excipients. Both approaches to the study of moisture sorption behaviour are presented, with the aim of finding the most suitable model for forecasting the sorption behaviour of studied compound.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Moisture Sorption Behaviour of Several Excipients by BET, GAB and Microcalorimetric Approaches

Roškar

Kmetec

2005

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Moisture content of solid-state pharmaceutical products is one of the main factors that affect drug stability, therefore suitable sorption studies need to be performed to assure drug quality throughout their shelf life. The Brunauer-Emmett-Teller (BET) and the Guggenheim-Anderson-de Boer (GAB) models are usually used for this purpose. Using gravimetrically obtained data, both methods were applied in the present work to evaluate the sorption characteristics of several excipients. Microcalorimetric analysis was also performed in order to evaluate the interaction between water and the substances. The results of these experiments show excellent agreement between data and the BET model up to 55% RH and the GAB model over the entire humidity range, confirmed by high values of the statistical determination coefficients. Furthermore, microcalorimetric measurements suggested that the hygroscopicity of solid materials could be estimated approximately using this approach.

show abstract

Section: Resultsmentioning

confidence: 83%

mentioning

confidence: 99%

Evaluation of the Moisture Sorption Behaviour of Several Excipients by BET, GAB and Microcalorimetric Approaches

Roškar

Kmetec

2005

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Disintegrants can however be affected by moisture uptake. The moisture sorption properties of at least some common disintegrants have been reported; 18,19 however, the link to changes in tablet or capsule dissolution must be inferred from changes observed in mechanical properties associated with the moisture uptake. In particular, it has been shown that moisture uptake associated with disintegrants in tablets can result in formation of micro-cracks due to disintegrant swelling, 20 which in turn can be surmised to influence the disintegrant's effectiveness.…”

Section: Dissolutionmentioning

confidence: 99%

Package Selection for Moisture Protection for Solid, Oral Drug Products

Waterman

MacDonald

2010

Journal of Pharmaceutical Sciences

103

View full text Add to dashboard Cite

“…11 Using the model proposed by the investigators who formulated this hypothesis, it was found that the sorbed moisture tended to be on the CCS or SSG surface (adsorption) as a normally condensed phase, rather than diffusing into the bulk (absorption). 6 The evidence then suggested the possibility of using frozen water of sorption on CCS and SSG for porosity determination.…”

Section: Introductionmentioning

confidence: 99%

“…Water molecules acted as a plasticizer causing a lowering of the glass transition temperature of polymer sorbents. 6 On the other hand, water condensation occurred because the surface of condensed water in the pore structure is concave and its vapor pressure is smaller than its saturation pressure. 7 It was referred to water in essentially unrestricted form and could be frozen.…”

Section: Introductionmentioning

confidence: 99%

Thermal porosity analysis of croscarmellose sodium and sodium starch glycolate by differential scanning calorimetry

Faroongsarng

Peck

2003

AAPS PharmSciTech

Self Cite

View full text Add to dashboard Cite

KEYWORDS: thermoporometry, differential scanning calorimetry (DSC), croscarmellose sodium (CCS), sodium starch glycolate (SSG) The aim of the study was to demonstrate the applicability of differential scanning calorimetry (DSC) on porosity analysis for cellulose and starch. Croscarmellose sodium (CCS) and sodium starch glycolate (SSG) were allowed to sorb moisture in 85%, 90%, 95%, and 100% relative humidity (RH) at 40°C for 24 hours. The pretreated samples were then subjected to DSC running temperature ranging from 25°C to -50°C at a cooling rate of 10°C/min. The cooling traces of water crystallization, if present, were transformed to porosity distribution via capillary condensation using Kelvin's equation. The porosity analysis of CCS and SSG was also done using nitrogen adsorption as a reference method. It was found that sorbed water could not be frozen (in cases of 85% and 90% RH) until the moisture content exceeded a cutoff value (in cases of 95% and 100% RH). The nonfreezable moisture content was referred to tightly bound, plasticizing water, whereas the frozen one may be attributed to loosely bound water condensation in pore structure of CCS and SSG surfaces. Not only capillary condensation but also the tightly bound, nonfreezable monolayer water lying along the inner pores of the surface contributed to porosity determination. Good agreement with less than 5% deviation of mean pore size was observed when the results were compared with nitrogen adsorption. The narrower pore size distributions, however, were obtained because of the limitations of the technique. It was concluded that pore analysis by DSC could be successful. Further research needs to be done to account for limitations and to extend the applicability of the technique.

show abstract

The Swelling & Water Uptake of Tablets III: Moisture Sorption Behavior of Tablet Disintegrants

Cited by 35 publications

References 13 publications

Evaluation of the Moisture Sorption Behaviour of Several Excipients by BET, GAB and Microcalorimetric Approaches

Evaluation of the Moisture Sorption Behaviour of Several Excipients by BET, GAB and Microcalorimetric Approaches

Package Selection for Moisture Protection for Solid, Oral Drug Products

Thermal porosity analysis of croscarmellose sodium and sodium starch glycolate by differential scanning calorimetry

Contact Info

Product

Resources

About