The sweetest polymer nanoparticles: opportunities ahead for glycogen in nanomedicine

Besford, Quinn A.

doi:10.1039/d4sm00261j

Soft Matter

2024

DOI: 10.1039/d4sm00261j

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The sweetest polymer nanoparticles: opportunities ahead for glycogen in nanomedicine

Quinn A. Besford

Abstract: Most cells take simple sugar (α-D-glucose) and assemble it into highly dense polysaccharide nanoparticles called glycogen. This is achieved through the action of multiple coupled-enzymatic reactions, yielding the cellular store...

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Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase b Complexes

Karakousi,

Karayianni,

Chrysina

et al. 2024

Polysaccharides

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Glycogen is a natural polysaccharide used as an energy storage macromolecule. The role of glycogen metabolism in type 2 diabetes mellitus has been under investigation for several years, along with its implication in cancer and cardiovascular and neurodegenerative diseases. Previous studies using pig liver glycogen with rabbit muscle glycogen phosphorylase (RMGPb), which catalyzes the first step of glycogen degradation to glucose-1-phosphate, showed that the surface of an average glycogen molecule is covered by a total of 20 RMGPb dimeric molecules. In this work, we selected oyster glycogen (Glyc) to investigate its interaction with RMGPb by employing biophysical techniques. Dynamic, static, and electrophoretic light scattering were used to investigate the solution behaviors and structures of both the Glyc molecule itself and the formed complexes between Glyc and GPb at different mixing ratios. It was established that the interaction between oyster Glyc and RMGPb is similar to that previously reported for pig liver glycogen. Moreover, the structure of the complexed GPb was monitored by fluorescence and FTIR spectroscopy.

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Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase b Complexes

Karakousi,

Karayianni,

Chrysina

et al. 2024

Polysaccharides

View full text Add to dashboard Cite

show abstract

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The sweetest polymer nanoparticles: opportunities ahead for glycogen in nanomedicine

Abstract: Most cells take simple sugar (α-D-glucose) and assemble it into highly dense polysaccharide nanoparticles called glycogen. This is achieved through the action of multiple coupled-enzymatic reactions, yielding the cellular store...

Cited by 1 publication

References 57 publications

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase b Complexes

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase b Complexes

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