Abstract:The regions at which the ER and mitochondria come into close proximity, known as ER-mitochondria contact sites provide essential platforms for the exchange of molecules between the two organelles and the coordination of various fundamental cellular processes. In addition to the well-established role of ER-mitochondria interfaces in calcium and lipid crosstalk, emerging evidence supports that a proper communication between ER and mitochondria is critical for the regulation of mitochondrial morphology and the in… Show more
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