The SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) and serum squamous cell carcinoma antigen (SCC-ag) function as prognostic biomarkers in patients with primary cervical cancer

Pan, Ling Ling; Cheng, Jing; Zhou, Min; Yao, Zhi Feng; Zhang, Ying Jian

doi:10.1007/s00432-011-1092-z

Cited by 37 publications

(25 citation statements)

References 46 publications

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“…Similar to our study, Pan et al 5 found that SUVmax of primary cervical cancer was not associated with preoperative SCC-ag levels. Pan et al did find that the higher the SUVmax of primary cancer, the poorer the prognosis.…”

Section: Discussionsupporting

confidence: 91%

Relationship of ¹⁸F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Xin

et al. 2016

Journal of Investigative Medicine

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The objectives of this retrospective study were to use preoperative fluoro-d-glucose (FDG) PET/CT in patients with primary cervical squamous cell carcinoma to explore the relationship between clinical, pathological and metabolic characteristics. Eighty consecutive patients with squamous cell carcinoma of cervix received FDG PET/CT scan before treatment. Metabolic tumor volume (MTV), total lesion glycolysis (TLG) and the peak standardized uptake value (SUVpeak) of the cervical tumors were calculated by an iterative adaptive algorithm. The association of these metabolic markers with serum squamous cell carcinoma antigen (SCC-ag), International Federation of Gynecology and Obstetrics (FIGO) stage, maximum tumor size and depth of cervical stromal invasion of the tumor was determined by the multivariate analysis. MTV and TLG were significantly higher in subjects with serum SCC-ag levels ≥3.95, with FIGO stage 1b2 and with a maximum tumor size of ≥4 cm (p≤0.009). Higher SUVpeak levels were associated with a maximum tumor size of ≥4 cm and with a cervical stromal invasion depth of ≥1/2 (p≤0.003). Multivariate analysis indicated that MTV was independently associated with FIGO stage Ib2 (p=0.041) and depth of cervical stromal invasion (p=0.020). TLG and SUVpeak were independently associated with maximum tumor size (p≤0.004) and depth of cervical stromal invasion (p≤0.013). Significant linear correlation was found between SUVpeak and tumor size; the Pearson correlation coefficient was 0.34 (p=0.002). Metabolic parameters such as MTV, TLG and SUVpeak are able to predict clinical and pathological status in preoperative cervical cancer.

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Section: Discussionsupporting

confidence: 91%

Relationship of ¹⁸F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Xin

et al. 2016

Journal of Investigative Medicine

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“…23 Recently, degree of FDG uptake on PET images was shown to be an independent prognostic factor in CC by accumulating evidence. 12,15,17,21 However, there have been conflicting results, and some studies found no significant association between PET results and prognosis. 11,13 Thus, we undertook this meta-analysis to evaluate the prognostic value of 18F-FDG PET or PET/CT in CC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography or PET-Computed Tomography in Cervical Cancer: A Meta-Analysis

Zhao

Mao³

et al. 2013

Int J Gynecol Cancer

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“…We analyzed 58 studies in full text, and 45 of them were excluded; the reasons for exclusion are listed in figure 1. Consequently, a total of 1,196 patients from 13 trials [5,6,11,12,13,14,15,16,17,18,19,20,21] were entered into the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Standardized Uptake Value on <sup>18</sup>F-FDG PET/CT as a Prognostic Factor for Survival of Women with Malignant Uterine Tumors: A Meta-Analysis

Pan

Yao²,

Ma³

2015

Gynecol Obstet Invest

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Background: Malignant uterine tumors are crucial in the evaluation of prognosis and the determination of therapeutic strategy. Aim: This meta-analysis of the available literature aimed to investigate the prognostic value of standardized uptake value (SUV) on fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (¹⁸F-FDG PET/CT) in uterine malignancies before treatment. Methods: The PubMed, MEDLINE and EMBASE databases (1990 to February 2014) were searched to identify studies evaluating SUV on ¹⁸F-FDG PET/CT as a prognostic tool for predicting long-term survival in patients with carcinomas of the uterus. The χ² test and the I² index were used to estimate heterogeneity among the trials selected in the meta-analysis. The combined hazard ratio was calculated by using a fixed- or random-effects model according to heterogeneity. Results: Thirteen studies with a total of 1,196 patients were eligible for analysis. High pretreatment SUV_max was significantly associated with poorer event-free survival and overall survival, and the summarized hazard ratio was 3.33 (95% confidence interval 2.34-4.74) and 1.31 (95% confidence interval 1.03-1.67), respectively. Conclusion: The present evidence indicates that SUV on ¹⁸F-FDG PET/CT seems to be a valuable prognostic indicator for survival of patients with malignant uterine tumors. Given that ¹⁸F-FDG PET/CT can provide both morphologic and functional information, we suggest utilizing PET/CT and its quantitative marker in uterine malignancies before treatment.

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The SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) and serum squamous cell carcinoma antigen (SCC-ag) function as prognostic biomarkers in patients with primary cervical cancer

Cited by 37 publications

References 46 publications

Relationship of ¹⁸F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Relationship of ¹⁸F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography or PET-Computed Tomography in Cervical Cancer: A Meta-Analysis

Standardized Uptake Value on <sup>18</sup>F-FDG PET/CT as a Prognostic Factor for Survival of Women with Malignant Uterine Tumors: A Meta-Analysis

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The SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) and serum squamous cell carcinoma antigen (SCC-ag) function as prognostic biomarkers in patients with primary cervical cancer

Cited by 37 publications

References 46 publications

Relationship of 18F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Relationship of 18F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography or PET-Computed Tomography in Cervical Cancer: A Meta-Analysis

Standardized Uptake Value on <sup>18</sup>F-FDG PET/CT as a Prognostic Factor for Survival of Women with Malignant Uterine Tumors: A Meta-Analysis

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Relationship of ¹⁸F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix

Relationship of ¹⁸F-Fdg Pet/Ct Metabolic, Clinical and Pathological Characteristics of Primary Squamous Cell Carcinoma of the Cervix