The susceptibility of cardiac arrhythmias after spinal cord crush injury in rats

Fernandes, Sílvia; Oatman, Emily; Weinberger, Jeremy; Dixon, Alethia J.; Osei‐Owusu, Patrick; Hou, Shaoping

doi:10.1016/j.expneurol.2022.114200

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…Nitroglycerin provocation is a standard part of the head-up tilt test protocol for assessing vasovagal syncope that increases the sensitivity for orthostatic intolerance symptoms but may lower the specificity for the reproduction of clinical symptoms ( 59 , 60 ). A high value of heart rate variability indicates a healthy autonomic and cardiovascular response, while a low value is suggestive of improper coordination between sympathetic and parasympathetic systems to provide an appropriate heart response ( 61 , 62 ). Tilt tests are especially useful in individuals with inappropriate sinus tachycardia, orthostatic tachycardia, unexplained syncope, or syndromes of orthostatic intolerance.…”

Section: Diagnosismentioning

confidence: 99%

Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination

Gómez-Moyano,

Rodríguez-Capitán,

Gaitán Román

et al. 2023

Front. Neurol.

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The COVID-19 pandemic has caused a challenge for our society due to the post-acute sequelae of the disease. Persistent symptoms and long-term multiorgan complications, known as post-acute COVID-19 syndrome, can occur beyond 4 weeks from the onset of the COVID-19 infection. Postural orthostatic tachycardia syndrome (POTS) is considered a variety of dysautonomia, which is characterized by chronic symptoms that occur with standing and a sustained increase in heart rate, without orthostatic hypotension. POTS can lead to debilitating symptoms, significant disability, and impaired quality of life. In this narrative review, the etiopathogenic basis, epidemiology, clinical manifestations, diagnosis, treatment, prognosis, and socioeconomic impact of POTS, as well as other related dysautonomic disorders, after COVID-19 infection and SARS-CoV-2 postvaccination, were discussed. After a search conducted in March 2023, a total of 89 relevant articles were selected from the PubMed, Google Scholar, and Web of Science databases. The review highlights the importance of recognizing and managing POTS after COVID-19 infection and vaccination, and the approach to autonomic disorders should be known by all specialists in different medical areas. The diagnosis of POTS requires a comprehensive clinical assessment, including a detailed medical history, physical examination, orthostatic vital signs, and autonomic function tests. The treatment of POTS after COVID-19 infection or vaccination is mainly focused on lifestyle modifications, such as increased fluid and salt intake, exercise, and graduated compression stockings. Pharmacotherapy, such as beta-blockers, fludrocortisone, midodrine, and ivabradine, may also be used in selected cases. Further research is needed to understand the underlying mechanisms, risk factors, and optimal treatment strategies for this complication.

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Section: Diagnosismentioning

confidence: 99%

Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination

Gómez-Moyano,

Rodríguez-Capitán,

Gaitán Román

et al. 2023

Front. Neurol.

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Therapeutic efficacy of adrenergic agents on systemic and spinal hemodynamics in an acute cervical spinal cord injury rodent model

Lee,

Liu,

Chen

2024

The Spine Journal

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Cardiovascular events in crush syndrome: on-site therapeutic strategies and pharmacological investigations

Zhang,

Tan,

Yang

et al. 2024

Front. Pharmacol.

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Crush syndrome often occurs after severe crush injury caused by disasters or accidents, and is associated with high mortality and poor prognosis. Cardiovascular complications, such as cardiac arrest, hypovolemic shock, and hyperkalemia-related cardiac dysfunction, are the primary causes of on-site death in crush syndrome. Prehospital evaluation, together with timely and correct treatment, is of great benefit to crush syndrome patients, which is difficult in most cases due to limited conditions. Based on current data and studies, early fluid resuscitation remains the most important on-site treatment for crush syndrome. Novel solutions and drugs used in fluid resuscitation have been investigated for their effectiveness and benefits. Several drugs have proven effective for the prevention or treatment of cardiovascular complications in crush syndrome, such as hypovolemic shock, hyperkalemia-induced cardiac complications, myocardial ischemia/reperfusion injury, ventricular dysfunction, and coagulation disorder experimentally. Moreover, these drugs are beneficial for other complications of crush syndrome, such as renal dysfunction. In this review, we will summarize the existing on-site treatments for crush syndrome and discuss the potential pharmacological interventions for cardiovascular complications to provide clues for clinical therapy of crush syndrome.

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The susceptibility of cardiac arrhythmias after spinal cord crush injury in rats

Cited by 3 publications

References 67 publications

Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination

Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination

Therapeutic efficacy of adrenergic agents on systemic and spinal hemodynamics in an acute cervical spinal cord injury rodent model

Cardiovascular events in crush syndrome: on-site therapeutic strategies and pharmacological investigations

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