The survival promoting peptide Y-P30 promotes cellular migration

Dash-Wagh, Suvarna; Neumann, Janine R.; Veitinger, Sophie; Grote-Westrick, Christian; Landgraf, Peter; Pape, Hans‐Christian; Kreutz, Michael R.; Holst, Alexander von; Wahle, Petra

doi:10.1016/j.mcn.2011.07.005

Cited by 9 publications

(9 citation statements)

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“…Furthermore, other vertebrates, such as wallabies, cats, dogs, horses or rodents, do not have dermcidin homologous genes [23]. Based on these facts, it is very astonishing that several publications claim that dermcidin is expressed in mice [19,24,25,26,27,28,29,30,31,32], rats [33] and the tammar wallaby [34]. In summary, since dermcidin homologous genes are only found in primates, one can conclude that dermcidin is an orphan gene.…”

Section: Homologous Dermcidin Genes In Humans and Other Speciesmentioning

confidence: 99%

“…Y-P30 has no influence on proliferation and differentiation of neural progenitors, neurons and astrocytes [32], but promotes neurite outgrowth from thalamic and cerebellar neurons [64]. Landgraf et al [64] identified pleiotropin and syndecan-2/3 as Y-P30 receptors.…”

Section: Functional Role Of Dermcidin-derived Peptidesmentioning

confidence: 99%

“…Furthermore, it was shown that overexpression of dermcidin in a hepatocarcinoma cell line promoted migration by activation of ρ-GTPases [57]. Likewise, Dash-Wagh et al [32] found that Y-P30 enhanced migration of T24 human bladder carcinoma cells and rat primary cortical astrocytes. In summary, most studies studying the effects of dermcidin expression in cancer cells postulate that ectopic dermcidin expression results in enhanced proliferation, survival and migration of cancer cells.…”

Section: Functional Role Of Dermcidin-derived Peptidesmentioning

confidence: 99%

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The Multiple Facets of Dermcidin in Cell Survival and Host Defense

Schittek¹

2012

J Innate Immun

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Eccrine sweat glands, which are distributed over the whole bodies of primates and humans, have long been regarded mainly to have a function in thermoregulation. However, the discovery of dermcidin-derived antimicrobial peptides in eccrine sweat demonstrated that sweat actively participates in the constitutive innate immune defense of human skin against infection. In the meantime, a number of studies proved the importance of dermcidin in skin host defense. Several reports also state that peptides processed from the dermcidin precursor protein exhibit a range of other biological functions in neuronal and cancer cells. This review summarizes the evidence gathered until now concerning the expression of dermcidin and the functional relevance of dermcidin-derived peptides.

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Section: Homologous Dermcidin Genes In Humans and Other Speciesmentioning

confidence: 99%

Section: Functional Role Of Dermcidin-derived Peptidesmentioning

confidence: 99%

Section: Functional Role Of Dermcidin-derived Peptidesmentioning

confidence: 99%

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The Multiple Facets of Dermcidin in Cell Survival and Host Defense

Schittek¹

2012

J Innate Immun

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“…Examples of upregulated proteins in Paper II that indicate neuroprotective function is transthyretin in the PHZ and dermcidin in the SNX. Previous preclinical studies have shown transthyretin to be neuroprotective following ICH (295)(296)(297)(298) and dermcidin to be protective against oxidative damage in in vitro and in animal models (299)(300)(301)(302). The role of such proteins in the pathophysiology of ICH needs to be further explored in future research.…”

Section: Figure 61 Protein Increase Mechanismsmentioning

confidence: 98%

Surgically Treated Intracerebral Haemorrhage : Pathophysiology and Clinical Aspects

Tobieson

2019

Linköping University Medical Dissertations

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To Ester!If it doesn't challenge you it doesn't change you! /the inside of my Ironman cap  Abstract i ABSTRACT Mortality and morbidity of intracerebral haemorrhage (ICH) is excessively high, and the case fatality rate has not improved in the last decades. Although surgery for ICH can be life-saving, no positive effect on functional outcome has been found in large cohorts of ICH patients. Increased understanding of the pathophysiology of ICH is needed to develop improved treatment strategies. Svensk sammanfattningiii KIRURGISK BEHANDLING AV HJÄRN-BLÖDNINGAR Spontan primär hjärnblödning (ICH), som inte beror på pulsåderbråck, utgör ca 12.5% av alla strokeinsjuknanden per år i Sverige, och står för en ansenlig del av den årliga stroke-relaterade dödligheten och förlusten av funktion. Endast en liten del av patienterna kan rehabiliteras åter till ett självständigt liv. I dagsläget saknas effektiv behandling utöver att förebygga att blödningen ökar i storlek genom snabb korrigering av koagulationsrubbningar och blodtryckssänkande behandling. Ca 5 % av alla ICH i Sverige opereras, men det saknas tydlig evidens för nyttan av kirurgi utöver som livräddande åtgärd.(ii-iii) Mikrodialys är en användbar metod för att studera hjärnskada efter ICH och kan kombineras med proteomik analys men det finns fallgropar och svårigheter med tekniken att ta hänsyn till, såsom att proteiner fastnar på mikrodialysmembranet.(iv) Den nationsövergripande genomgången av kirurgiskt behandlade ICH patienter påvisar likheter avseende patienternas ålder och medvetandegrad, men skillnader i volym och lokalisation av opererade blödningar, samt i den postoperativa vården. Dessa skillnader bör vara fokus för framtida forskningsstudier för att möjliggöra utformningen av bättre riktlinjer för klinisk praxis.

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“…The underlying mechanisms for this broad spectrum of biological activities are still largely unclear. Cell migration and neurite outgrowth promoting activities appear to rely on binding of Y-P30 to syndecans and pleiotrophin [2,7-9]. Other interactions have been reported for calreticulin [4], HSP70 [10] and NCK [11] and it was speculated that these interactions trigger the anti-apoptotic effects of the peptide.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide

et al. 2014

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BackgroundThe survival promoting peptide Y-P30 has a variety of neuritogenic and neuroprotective effects in vitro and in vivo. In previous work we reported the expression of Y-P30/dermcidin in maternal peripheral blood mononuclear cells (PBMCs) and the transport of the protein to the fetal brain. In this study we analyzed hormonal regulation of Y-P30 in human immune cells and expression of Y-P30 in the placenta. We further studied the stability and secretion of the Y-P30 peptide.ResultsWe found indications that Y-P30 might be produced in human placenta. The Y-P30 mRNA was rarely found in isolated human PBMCs and alpha-feto-protein, human chorionic gonadotropin as well as estradiol combined with progesterone could not induce Y-P30 expression. Y-P30 was found to be extraordinarily stable; therefore, contamination with the peptide and the Y-P30/Dermcidin precursor mRNA is a serious concern in experiments looking at the expression of Y-P30/Dermcidin. In cultured cell lines and primary neurons we found that Y-P30 could be released, but neuronal uptake of Y-P30 was not observed.ConclusionsOur data suggest that a source of Y-P30 apart from eccrine glands might be the placenta. The peptide can be secreted together with the signaling peptide and it might reach the fetal brain where it can exert its neuritogenic functions by binding to neuronal membranes.

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The survival promoting peptide Y-P30 promotes cellular migration

Cited by 9 publications

References 56 publications

The Multiple Facets of Dermcidin in Cell Survival and Host Defense

The Multiple Facets of Dermcidin in Cell Survival and Host Defense

Surgically Treated Intracerebral Haemorrhage : Pathophysiology and Clinical Aspects

Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide

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