The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma

Du, Yabing; Dong, Bin; Shen, Luyan; Yan, Wanpu; Dai, Liang; Xiong, Hongchao; Zeng, Liang; Kang, Xiaozheng; Qin, Bin; Chen, Ke-Neng

doi:10.1016/j.jss.2014.01.017

Cited by 31 publications

(35 citation statements)

References 19 publications

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“…This study indicates that HOXC8 expression may be used as prognostic markers in patients with ESCC (Du et al, 2014).…”

Section: Notementioning

confidence: 62%

“…The gene is also expressed in both the neural tube and the somites in the prospective thorax (Pollock et al, 1992;Shashikant and Ruddle, 1996). Cancers: Elevated HOXC8 expression is detected in breast cancer (Li et al, 2014;Li et al, 2010), cervical cancer (Alami et al, 1999), prostate cancer (Waltregny et al, 2002), esophageal cancer (Du et al, 2014), pancreatic cancer (Adwan et al, 2011). Organs: HOXC8 is expressed in hematopoietic organs, brain, breast, placenta, liver, bone marrow, kidney, intestine and nervous systems, etc.…”

Section: Expressionmentioning

confidence: 99%

“…Stem cells: HOXC8 is expressed in vascular wallresident multi-potent stem cells (VW-MPSCs), and silencing its expression significantly reduces cell sprouting capacity and increases expression of the smooth muscle cells marker genes (Klein et al, 2013). Cancers: HOXC8 plays an essential role in cancer development, including breast, prostate, cervical and pancreatic cancers by facilitating cell migration and invasion (Adwan et al, 2011;Alami et al, 1999;Axlund et al, 2010;Du et al, 2014;Li et al, 2010).…”

Section: Functionmentioning

confidence: 99%

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HOXC8 (homeobox C8)

Huang¹,

Li²

2015

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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“…This study indicates that HOXC8 expression may be used as prognostic markers in patients with ESCC (Du et al, 2014).…”

Section: Notementioning

confidence: 62%

Section: Expressionmentioning

confidence: 99%

Section: Functionmentioning

confidence: 99%

See 1 more Smart Citation

HOXC8 (homeobox C8)

Huang¹,

Li²

2015

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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“…Alterations in the expression patterns of HOX gene family members cause dysregulation of HOX protein function, further leading to unbalanced cell proliferation and differentiation; this is hypothesized to contribute to tumorigenesis. In the last two decades, studies have identified that the expression patterns of HOX genes are abnormal in a variety of tumors, including esophageal cancer (7)(8)(9)(10)(11). Our previous studies (8,10) demonstrated that HOXC6 serves a key function in esophageal squamous cell carcinoma (ESCC) and is abnormally expressed in ESCC tissues.…”

Section: Introductionmentioning

confidence: 99%

“…In the last two decades, studies have identified that the expression patterns of HOX genes are abnormal in a variety of tumors, including esophageal cancer (7)(8)(9)(10)(11). Our previous studies (8,10) demonstrated that HOXC6 serves a key function in esophageal squamous cell carcinoma (ESCC) and is abnormally expressed in ESCC tissues. Single-surgery patients with increased expression of HOXC6 exhibited a significantly shorter median survival time compared with patients with decreased expression of HOXC6.…”

Section: Introductionmentioning

confidence: 99%

Increased HOXC6 expression predicts chemotherapy sensitivity in patients with esophageal squamous cell carcinoma

et al. 2017

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Abstract. Increased expression of homeobox C6 (HOXC6) predicts poor prognosis of patients with esophageal squamous cell carcinoma (ESCC) and promotes ESCC cell proliferation. Additionally, the expression of HOXC6 was upregulated in chemosensitive ESCC cell lines. Therefore, it was hypothesized that HOXC6 may be associated with chemosensitivity of ESCC. Patients with ESCC who underwent neoadjuvant chemotherapy followed by surgery by a single-surgeon team between January 2000 and December 2012 were enrolled in the present study. Pretreatment biopsy specimens and postoperative resection samples were collected. Immunohistochemistry was performed to examine HOXC6 expression, and the association between HOXC6 expression and tumor regression grade (TRG) was analyzed. In cell lines exhibiting stable knockdown of HOXC6, Cell Counting Kit-8 assays were used to evaluate the chemosensitivity of cells to various concentrations of cisplatin and paclitaxel. A total of 51 pretreatment biopsy specimens were assessed, and patients with increased expression of HOXC6 in pretreatment biopsy specimens exhibited higher TRGs. A total of 186 surgical samples were evaluated; HOXC6 was expressed at a decreased level in patients with higher TRG and at a high level in patients with lower TRG. In addition, downregulation of HOXC6 decreased the sensitivity of ESCC cell lines to cisplatin and paclitaxel, resulting in an increased half-maximal inhibitory concentration. Increased expression of HOXC6 prior to treatment was associated with chemosensitivity in ESCC tissues.

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Lung Stem Cells in the Epithelium and Vasculature

Firth¹,

Yuan²

2015

Stem Cell Biology and Regenerative Medicine

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The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma

Cited by 31 publications

References 19 publications

HOXC8 (homeobox C8)

HOXC8 (homeobox C8)

Increased HOXC6 expression predicts chemotherapy sensitivity in patients with esophageal squamous cell carcinoma

Lung Stem Cells in the Epithelium and Vasculature

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