The survival of chick retinal ganglion cells in response to brain-derived neurotrophic factor depends on their embryonic age

Rodríguez‐Tébar, Alfredo; Jeffrey, Peter L.; Thoenen, H.; Barde, Yves‐Alain

doi:10.1016/0012-1606(89)90256-x

Cited by 139 publications

(67 citation statements)

References 35 publications

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“…Bennett, 1981). BDN F promotes the survival of RGC in vitro (Johnson et al, 1986;Rodríguez-Tébar et al, 1989;Thanos et al, 1989;Cohen-Cory and Fraser, 1994) and in vivo (Mey and Thanos, 1993;Mansour-Robaey et al, 1994;Unoki and LaVail, 1995;Weibel et al, 1995) [Voci et al (1993), as cited in Garner et al (1996)]. BDN F has been suggested to be a trophic factor derived from the tectum, and expression of BDN F mRNA in the tectum of several different species supports this hypothesis (Leibrock et al, 1989;Cohen-Cory and Fraser, 1994;).…”

Section: Bdnf As a Target-derived Trophic Factormentioning

confidence: 98%

“…RGC from all species that were examined respond to BDNF in vitro (Johnson et al, 1986;Rodríguez-Tébar et al, 1989;CohenCory and Fraser, 1994), but it is not known if BDN F acts in vivo as a target-derived factor or as a local retinal factor. Neurons in the SGFSi and SGC layers of the tectum receive innervation from RGC axons (Crossland et al, 1975;Repérant and Angaut, 1977).…”

Section: Retrograde Transport Of Bdnf From the Tectum To The Retinamentioning

confidence: 99%

“…In addition to its established survival functions in vitro (Johnson et al, 1986;Rodríguez-Tébar et al, 1989;Cohen-Cory and Fraser, 1994), BDNF increases in vivo the survival of injured RGC in birds [Voci et al (1993), as cited in Garner et al (1996)] and in mammals (Mey and Thanos, 1993;Mansour-Robaey et al, 1994;Weibel et al, 1995). BDNF also regulates the branching of developing axons in the tectum (Cohen-Cory and Fraser, 1995) and cortex (Cabelli et al, 1995) and the branching of dendritic processes of cortical neurons in vitro (McAllister et al, 1995(McAllister et al, , 1996.…”

Section: What Is the Function Of Bdnf In The Visual System?mentioning

confidence: 99%

“…Most retinal ganglion cells (RGC) degenerate after target removal or optic stalk transection in chicken (Hughes and LaVelle, 1975;Vanselow et al, 1990). RGC can be maintained by brain-derived neurotrophic factor (BDN F) in vitro (Johnson et al, 1986;Rodríguez-Tébar et al, 1989;Cohen-Cory and Fraser, 1994), and cells in the RGC layer express the BDNF receptor trkB (Okazawa et al, 1993(Okazawa et al, , 1995Perez and Caminos, 1995;Rickman and Brecha, 1995;Cohen-Cory et al, 1996;Garner et al, 1996;Hallböök et al, 1996). The expression of BDNF mRNA in target regions and its upregulation by physiological input further support the view that BDNF derived from the target plays a role in the maintenance of RGC (Castrén et al, 1992;Cohen-Cory and Fraser, 1994;Schoups et al, 1995) (for review, see von Bartheld, 1998a), but the retrograde transport of BDNF from the tectum to the retina has not been shown in the developing visual system.…”

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confidence: 99%

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Contributions of the Optic Tectum and the Retina as Sources of Brain-Derived Neurotrophic Factor for Retinal Ganglion Cells in the Chick Embryo

1998

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Retinal ganglion cells (RGC) are supported by brain-derived neurotrophic factor (BDNF), but it is not known if BDNF acts as a target-derived factor or as an afferent or autocrine trophic factor. Here we demonstrate that BDNF mRNA is expressed in the retinorecipient layer of the chick optic tectum as well as in the inner nuclear layer and ganglion cell layer of the retina. Amacrine cells rather than RGC were the main source of BDNF mRNA in the ganglion cell layer, as determined by in situ hybridization that was combined with retrograde labeling of RGC and destruction of RGC by optic stalk transection, followed by quantitative RT-PCR. Cells in the ganglion cell layer as well as the retinorecipient layers of the optic tectum were BDNF-immunolabeled. After injections into the tectum, radioiodinated BDNF was transported to the retina where autoradiographic label accumulated in the inner plexiform and ganglion cell layers. After intraocular injection, iodinated BDNF accumulated in these same retinal layers and correlated with the distribution of p75 neurotrophin receptor protein. The majority of cross-linked receptor-bound BDNF in the retina immunoprecipitated with p75 antibodies. No difference in the intensity of BDNF immunolabel was observed in the experimental retina or tectum after optic stalk transection, indicating that most of the BDNF in the RGC was not derived from the optic tectum. These data indicate that a substantial fraction of the BDNF in the ganglion cell layer is derived from local sources, afferents within the retina, rather than from the optic tectum via retrograde transport.

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Section: Bdnf As a Target-derived Trophic Factormentioning

confidence: 98%

Section: Retrograde Transport Of Bdnf From the Tectum To The Retinamentioning

confidence: 99%

Section: What Is the Function Of Bdnf In The Visual System?mentioning

confidence: 99%

mentioning

confidence: 99%

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Contributions of the Optic Tectum and the Retina as Sources of Brain-Derived Neurotrophic Factor for Retinal Ganglion Cells in the Chick Embryo

1998

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“…However, it remains controversial whether, and how, BDNF modulates RGC survival in vivo and whether this would be a targetmediated or local effect. BDNF promotes RGC survival in vitro (Rodriguez-Tebar et al, 1989;Cohen-Cory and Fraser, 1994;Meyer-Franke et al, 1995) and in vivo (Ma et al, 1998), but mice lacking all isoforms of the TrkB receptor show no apoptotic RGC death (Rohrer et al, 2001). Interestingly, recent evidence in mammals indicates that BDNF, signaling through the full-length TrkB receptor, influences developmental death dynamics by controlling the timing of programmed cell death but not the final number of RGCs (Pollock et al, 2003).…”

Section: Cell-autonomous Trkb Signaling Is Important For the Growth Amentioning

confidence: 99%

Cell-Autonomous TrkB Signaling in Presynaptic Retinal Ganglion Cells Mediates Axon Arbor Growth and Synapse Maturation during the Establishment of Retinotectal Synaptic Connectivity

Marshak¹,

Nikolakopoulou²,

Dirks³

et al. 2007

J. Neurosci.

111

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Elevated Glutamate Levels in the Vitreous Body of an In Vivo Model of Optic Nerve Ischemia

Kim

Kang²,

Choung³

et al. 2000

Arch Ophthalmol

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To explore the possibility that an elevation of glutamate levels in the vitreous might be associated with the microvascular compromise of the optic nerve. Materials and Methods: Endothelin-1, 0.1 µg/d (5 rabbits), or balanced salt solution (4 rabbits) was delivered to the perineural region of the anterior optic nerve by osmotically driven minipumps for 2 weeks. Vitreous specimens were obtained, and their amino acid contents were determined by high-performance liquid chromatography. Results: There was a statistically significant elevation in the mean ± SEM vitreous concentrations of glutamate (264% ± 41%; P = .04), aspartate (269% ± 31%; P = .04), and glycine (232% ± 26%; P = .04) in the eyes subjected to endothelin-1 when compared with the fellow control eyes. Conclusion: Administration of endothelin-1 to the microvasculature of the optic nerve leads to elevation of glutamate, aspartate, and glycine concentrations in the vitreous. Clinical Relevance: The increase of excitatory amino acids in the vitreous might be associated with various ischemic processes of the optic nerve, including glaucomatous optic neuropathy, and may play a role in the neuronal damage that is seen in these diseases.

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The survival of chick retinal ganglion cells in response to brain-derived neurotrophic factor depends on their embryonic age

Cited by 139 publications

References 35 publications

Contributions of the Optic Tectum and the Retina as Sources of Brain-Derived Neurotrophic Factor for Retinal Ganglion Cells in the Chick Embryo

Contributions of the Optic Tectum and the Retina as Sources of Brain-Derived Neurotrophic Factor for Retinal Ganglion Cells in the Chick Embryo

Cell-Autonomous TrkB Signaling in Presynaptic Retinal Ganglion Cells Mediates Axon Arbor Growth and Synapse Maturation during the Establishment of Retinotectal Synaptic Connectivity

Elevated Glutamate Levels in the Vitreous Body of an In Vivo Model of Optic Nerve Ischemia

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