The Surgical Treatment of Keloids

Cosman, Bard; Crikelair, George F.; Ju, David; Gaulin, J. C.; Lattes, Raffaele

doi:10.1097/00006534-196104000-00001

Cited by 252 publications

(134 citation statements)

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“…147,148 They spread beyond the margins of the original wound and are associated with increased collagen deposition and fibroproliferation. [149][150][151] Both are associated with significant morbidity.…”

Section: 117mentioning

confidence: 99%

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Rees¹,

Greaves²,

Baguneid

et al. 2015

Advances in Wound Care

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Section: 117mentioning

confidence: 99%

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Rees¹,

Greaves²,

Baguneid

et al. 2015

Advances in Wound Care

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“…scars and exceeds in size by indefinite progression (8,(33)(34)(35)(36). As a result, keloids are characterized by exuberant, erythematous scars, which grow beyond the confines of the original wounds and rarely regress over time (9) (Fig.…”

Section: Keloids Versus Hypertrophic Scarsmentioning

confidence: 99%

Keloids: Current concepts of pathogenesis (Review)

Bran¹

2009

Int J Mol Med

189

208

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Abstract. Excess scar formation occurs after dermal injury as a result of abnormal wound healing. Hypertrophic scars and keloids both represent fibrotic skin conditions which can be very difficult, even frustrating, to treat. Identification of differences between hypertrophic scars, keloids and normal scars are a prerequisite for finding the correct therapeutical concept. Despite the relatively high prevalence of keloids in the general population, the mechanisms underlying keloid formation are only partially understood. This fact is reflected in the multiple treatment modalities, of which no single treatment has proven to be widely effective. Advances in our understanding of the wound healing process reveal new pathophysiological concepts for keloid formation. Our article presents an overview on physiological wound healing and the pathogenesis of scar formation, differentiates keloids from hypertrophic scars and reviews current hypotheses for keloid formation. This information might assist in deciphering the complexity of keloid pathogenesis and help in the development of an efficacious therapeutical strategy.

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“…Associated pruritus, dysesthesia or pain as well as restricted range of motion are frequently noted with keloids [1]. Malignant transformation of keloids is rare [4].…”

Section: Introductionmentioning

confidence: 99%

Keloidoscope: in search for the ideal treatment of keloids

Anchlia

Rao

Bonanthaya

et al. 2009

J. Maxillofac. Oral Surg.

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Although keloids were recognised in the Smith Papyrus of ancient times, the precise definition, cause and management have remained elusive. Several forms of treatment have been used with varying success. Objectives This study assesses and compares the value of intralesional steroid (Triamcinolone acetonide 40mg/ml), cryotherapy and cryotherapy with intralesional steroid in the treatment of keloids. Methodology 33 patients were studied, 11 each in the three arms and the volume of the keloids was recorded using wax patterns of alginate impressions of the keloids to note the change in size postoperatively. Results The best average percentage response was observed is patients who received both Cryotherapy (CRY) and Intralesional Steroid (ILS) (69.02%) followed by patients who received only intralesional steroid (43.98%). Among the patients who received only cryotherapy, the average percentage response was only 39.24%. 72.73% patients who received intralesional steroid with cryotherapy showed more than 50% improvement (good response) while only 9.09% patients who received intralesional steroid alone and cryotherapy alone showed similar improvement. Conclusion In patients with keloids good response can be obtained with CRY with ILS as compared to ILS alone and CRY alone.

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The Surgical Treatment of Keloids

Cited by 252 publications

References 0 publications

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Keloids: Current concepts of pathogenesis (Review)

Keloidoscope: in search for the ideal treatment of keloids

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