The surgical significance of carcinoma of the gallbladder

Pemberton, L. Beaty; Diffenbaugh, Willis F.; Strohl, E. Lee

doi:10.1016/0002-9610(71)90263-7

Cited by 27 publications

(5 citation statements)

References 4 publications

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“…In Britain less than 1 per cent of carcinomas arise in the gallbladder (Solan and Jackson, 1971). The condition appears to be more common in the United States (Holmes and Mark, 1971;Pemberton et al, 1971). In contrast, owing to the lack of a cancer registry, the actual incidence of carcinoma of gallbladder in India is subject to a variety of opinions.…”

Section: Discussionmentioning

confidence: 99%

Primary carcinoma of the gallbladder

Prakash

Sharma

Pandit

1975

British Journal of Surgery

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The clinical and pathological features of 100 consecutive cases of primary carcinoma of the gallbladder, treated by a single surgical unit, are described. Females out numbered males by 2 to 1. The maximum incidence was seen in the fifth decade. Pain and the presence of a mass were the two most common clinical features. Gallstones coexisted in 45 per cent of cases. Ancillary investigations were of little value in preoperative diagnosis. At laparotomy biopsy alone was possible in a large number of cases owing to the advanced disease process. Two patients were alive 5 years after surgery. Prophylactic cholecystectomy for all diseased gallbladders, whether symptomatic or not, is advocated.

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Section: Discussionmentioning

confidence: 99%

Primary carcinoma of the gallbladder

Prakash

Sharma

Pandit

1975

British Journal of Surgery

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“…26 Gallstones are found in 72-90% of carcinomas of the gallbladder. 5,6,18,27 Because of this common association, cholelithiasis is often regarded as having an important influence in the pathogenesis of carcinoma of the gallbladder. 21 In 12 (30%) of our adenocarcinoma cases, the gallbladder harbored a stone, as opposed to 4 (66.7%) of our squamous and adenosquamous carcinoma cases.…”

Section: Fna Of Gallbladder Lesionsmentioning

confidence: 99%

Ultrasound-guided fine-needle aspiration cytology diagnosis of gallbladder lesions: A study of 82 cases

Das¹,

Tripathi²,

Bhambhani³

et al. 1998

Diagn. Cytopathol.

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Carcinoma of the gallbladder (GB) is among the five most common forms of cancers and tops the list of gastrointestinal malignancies in females of the Delhi region. Lack of specific signs and symptoms prevents early detection of GB carcinoma. However, in recent years ultrasonographically (US)‐guided fine‐needle aspiration (FNA) cytology has been found to be a reliable procedure for its diagnosis. The present study was carried out during a period of 5 yr (1986–1990) in 64 female and 18 male patients to find out the diagnostic utility of US‐guided FNA cytology in gallbladder lesions. Ultrasonography in these 82 cases revealed a mass in the gallbladder/GB area in 74 (90.2%), a mass in the GB/pancreas in 1 (1.2%), gallstones in 32 (39.0%), and miscellaneous gallbladder lesions in 4 (4.9%). The other findings included space‐occupying lesions in liver in 18 (22.0%), portal lymphadenopathy in 12 (14.6%), and infiltration in other organs in 7 (8.5%). The initial cytodiagnosis was malignancy in 48 cases, inflammatory in 12, and inadequate in 22. Following review of the smears by one of the investigators (D.K.D.), the number of malignant cases remained 48 (58.5%). There were 10 (12.2%) inflammatory and 24 (29.3%) inadequate cases. Adenocarcinoma was the most common malignancy (83.3%), followed by squamous‐cell and adenosquamous carcinoma (12.5%) and small round cell tumors (4.2%). The 10 inflammatory lesions showed slight (+) to excessive (+++) neutrophilic infiltration and included one case each of xanthogranulomatous cholecystitis and a necrotizing granulomatous lesion likely to be of tuberculous etiology. Diagn. Cytopathol. 1998; 18:258–264. © 1998 Wiley‐Liss, Inc.

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“…In most series patients with advanced disease are in majority, i.e., patients with tumor spread through the gallbladder wall to the serosa (stage 111), of the regional lymph nodes (stage IV), beyond the regional lymph nodes (stage V) [4][5][6][7]. Almost all patients surviving more than five years have had an preoperative diagnosis of benign gallbladder disease and the cancer revealed by microscopic examinations.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma of the gallbladder–a natural history type of study

Jönsson¹,

Pettersson²

1982

Journal of Surgical Oncology

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A retrospective analysis of the natural history of 63 consecutive patients with gallbladder cancer during 30 years at a county hospital in Sweden is presented. Dominating symptoms were pain, jaundice, weight loss, and a palpable mass. Fifty patients were subjected to surgery. Forty-one patients had an extensive tumor spread in the abdominal cavity. Twenty-six patients were cholecystectomized and in 24 patients biopsy from the tumor was the only measure taken. The gallbladder cancer was occult in four patients. The median survival time was 1 month in patients who underwent autopsy, 2 months in patients who were biopsied and 4 months in patients who were cholecystectomized. The overall 6-month and 1-year crude survival rates were 16% and 8%, respectively. Comparison with previous reports regardless of treatment reveals that the prognosis of gallbladder cancer is still dismal and unchanged.

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The surgical significance of carcinoma of the gallbladder

Cited by 27 publications

References 4 publications

Primary carcinoma of the gallbladder

Primary carcinoma of the gallbladder

Ultrasound-guided fine-needle aspiration cytology diagnosis of gallbladder lesions: A study of 82 cases

Carcinoma of the gallbladder–a natural history type of study

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