The Surgical Management of Prostate Cancer

Sebesta, Elisabeth M.; Anderson, Christopher B.

doi:10.1053/j.seminoncol.2018.01.003

Cited by 72 publications

(62 citation statements)

References 70 publications

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“…There is mounting evidence that circRNAs play critical roles in the regulation of cancer development and progression [56,[65][66][67][68][69][70][71][72]. Prostate cancer is one of the most common aggressive tumors in elderly men [73]. Recently, Chen et al found that circCSNK1G3 can promote prostate cancer cell proliferation at least partially through interaction with miR-181b/d [65].…”

Section: Circrnas In Cancermentioning

confidence: 99%

Circular RNAs: Promising Biomarkers for Age-related Diseases

Pan

Xiong

2020

Aging and disease

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Aging is a complex biological process closely linked with the occurrence and development of agerelated diseases. Despite recent advances in lifestyle management and drug therapy, the late diagnosis of these diseases causes severe complications, usually resulting in death and consequently impacting social economies. Therefore, the identification of reliable biomarkers and the creation of effective treatment alternatives for agerelated diseases are needed. Circular RNAs (circRNAs) are a novel class of RNA molecules that form covalently closed loops capable of regulating gene expression at multiple levels. Several studies have reported the emerging functional roles of circRNAs in various conditions, providing new perspectives regarding cellular physiology and disease pathology. Notably, accumulating evidence demonstrates the involvement of circRNAs in the regulation of age-related pathologies, including cardio-cerebrovascular disease, neurodegenerative disease, cancer, diabetes, rheumatoid arthritis, and osteoporosis. Therefore, the association of circRNAs with these agerelated pathologies highlights their potential as diagnostic biomarkers and therapeutic targets for better disease management. Here, we review the biogenesis and function of circRNAs, with a special focus on their regulatory roles in aging-related pathologies, as well as discuss their potential as biological biomarkers and therapeutic targets for these diseases.

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Section: Circrnas In Cancermentioning

confidence: 99%

Circular RNAs: Promising Biomarkers for Age-related Diseases

Pan

Xiong

2020

Aging and disease

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“…CRPC and mCRPC still were the trickiest trouble during diagnosis and treatment of prostate cancer. With the development of urology in recent years, many different treatments occurred, including chemotherapy, radiation therapy, targeted therapy and immunotherapy, the overall survival rate had rase markedly (7)(8)(9). It still lacks an effective and sensitive treatment drugs for prostate cancer, especially the acute demand for novel drugs in treating CRPC (10).…”

Section: Introductionmentioning

confidence: 99%

OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1

Liao

Wang

et al. 2020

Preprint

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Background: Prostate cancer (PCa) is currently the most common and highest incidence of cancer in men all over the world. OTUB1 has been reported to be a critical role in various kinds of cancers, closely related with proliferation, migration and clinical prognosis. The aim of this research was to investigate the influence of OTUB1 in PCa, and to identify the mechanism underlying function.Methods: Using TCGA database, we identified OTUB1 higher expression in PCa. We observed the changes of functional behavior in PC3 and C4-2 cells through overexpression or knock down of OTUB1. Subcutaneous ectopic tumors were conducted and IHC of tumors tissue in nude mice also carried out. Western blotting and co-immunoprecipitations assays were conducted to identify that OTUB1 interacted with cyclin E1.Results: We found that the expression of OTUB1 was significant higher in PCa than in Benign prostatic hyperplasia (BPH). The overexpression of OTUB1 promoted obviously proliferation and migration in PC3 and C4-2 cells via regulating Cyclin E1 protein stability, and contrary observation in OTUB1 knock down. The nude mice experiment further explained our conclusions. We finally identified that OTUB1 promoted the progression of PCa by deubiquitinating and stabling cyclin E1.Conclusions: Our findings reveal the important role of OTUB1 in PCa, OTUB1 promoted cyclin E1 protein stability in PCa. Knock down of OTUB1 can significantly repressed development of cancer. OTUB1 might serve a newly and potential therapy target for PCa.

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“…The extremely high morbidity and mortality make PC one of the most serious threats to men's health [2]. Nowadays, the PC treatments only rely on surgery or radiotherapy when the cancer is still in the localized stage [3,4]. Thus the survival rate would be commonly improved if PC could be diagnosed in the early stage.…”

Section: Introductionmentioning

confidence: 99%

Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression

Shi

et al. 2020

BMC Cancer

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Background: Prostate cancer (PC), a common malignant tumor, is the second-leading cause of cancer death among American men. Its successful treatment greatly relies on the early diagnose. Engrailed-2 (EN2) has been confirmed being existed with a high level in the urine of PC patients. In this study, to explore the application of EN2 in PC, we detected the immunohistochemical staining difference and EN2 expression level between benign prostatic hyperplasia (BPH) and PC. Methods: We developed a monoclonal antibody against the helix 3 in EN2 and confirmed its specificity with Western blotting (WB) and immunofluorescence detecting the subcellular localization of endogenous and exogenous EN2 in three PC cell lines (LNCap, PC3, and DU145). We conducted immunohistochemical staining using this homemade antibody, and RT-PCR to detect the expression of EN2 in 25 PC and 25 BPH cases, and analyzed the correlation of EN2 expression and PC clinical staging. Results: The results of WB and immunofluorescence showed our homemade EN2 monoclonal antibody could specifically bind endogenous and exogenous EN2 protein in three different PC cell lines. Endogenous EN2 was generally expressed in the cytoplasm and exogenous EN2 mostly existed in the nucleus of these cell lines. Immunohistochemical staining in PC had extremely stronger signals than that in BPH, suggesting a higher EN2 expression level in PC, which was confirmed by RT-PCR. Interestingly, the stained areas in BPH tissues were mainly in nucleus and cytoplasm, while in PC tissues were mainly on cytomembrane. Moreover, the expression level of EN2 was positively correlated with the PC clinical staging. Conclusion: Using our homemade EN2 antibody, we have found different staining patterns and expression level of EN2 in BPH and PC,which may be helpful to predict prostatic disease progression.

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The Surgical Management of Prostate Cancer

Cited by 72 publications

References 70 publications

Circular RNAs: Promising Biomarkers for Age-related Diseases

Circular RNAs: Promising Biomarkers for Age-related Diseases

OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1

Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression

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The Surgical Management of Prostate Cancer

Cited by 72 publications

References 70 publications

Circular RNAs: Promising Biomarkers for Age-related Diseases

Circular RNAs: Promising Biomarkers for Age-related Diseases

OTUB1&nbsp;Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1

Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression

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OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1