The surge of Bell’s palsy in COVID - pandemic era

Srinivas, C. V.; Kauser, Safina; Sangoli, Bhavana

doi:10.18203/issn.2454-5929.ijohns20204628

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…According to them, 21% of patients with BP had active or recent symptoms consistent with SARS‐CoV‐2 infection, suggesting an excess risk of BP during or after COVID‐19 [5]. Srinivas et al [6] documented a higher percentage (0.8%) of BP cases in 2020 as compared to the prepandemic time (0.05%). Tamaki et al [7] in August 2021 found a higher incidence of BP in patients with COVID‐19 (0.08%).…”

Section: Introductionmentioning

confidence: 99%

Surge of Bell's Palsy in the era of COVID‐19: Systematic review

Gupta

Jawanda²

2022

Euro J of Neurology

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Background and purpose With the progression of coronavirus infectious disease 2019 (COVID‐19), various neurological manifestations have been noticed in infected patients, and Bell's Palsy (BP) is one of the peripheral neuropathies among those. BP has been associated with various other viral agents. Its evidence in patients with COVID‐19 signifies the possibility of association between BP and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). This research was undertaken to evaluate the number of published cases of BP as the only major neurological manifestation in patients with COVID‐19 from March 2020 to December 2021 and to investigate the association of SARS‐CoV‐2 and BP. Methods A systematic review of the published English literature was performed using an electronic search in the PubMed/Medline, Scopus, Research Gate, Research Square, and Google Scholar databases, using keywords such as "COVID‐19" OR/AND "SARS‐CoV‐2" OR/AND "Bell's palsy" OR/AND "facial nerve palsy" OR/AND "neurological" OR/AND "manifestation". Results The search strategy revealed 32 relevant publications with a total of 46 patients. BP was the initial manifestation in 37% of cases, and in 63% of cases it developed after COVID‐19 symptoms; 71.7% of cases showed complete recovery, and 21.7% showed only partial relief from BP. Conclusions Although the number of documented cases in this research is low, evidence of BP as the only major neurological manifestation in patients with COVID‐19 signifies an important clinical finding and the possibility of another viral etiology of BP. More evidence is needed to establish the exact correlation between these two entities.

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Section: Introductionmentioning

confidence: 99%

Surge of Bell's Palsy in the era of COVID‐19: Systematic review

Gupta

Jawanda²

2022

Euro J of Neurology

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“…Some studies have suggested an increase in the incidence of BP in patients with COVID-19 compared to the pre-pandemic era. 7 Srinivas et al 8 reported a higher incidence of BP in 2020 as compared to previous years. In a similar way, Codeluppi et al 9 demonstrated a higher incidence of BP during the pandemic compared to a similar period in the previous year.…”

Section: Introductionmentioning

confidence: 95%

Has Coranavirus Disease 2019 Changed the Incidence and Outcome of Bell’s Palsy?

Lassaletta,

Cuadrado,

Patino

et al. 2024

The Journal of International Advanced Otology

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Background: Objectives: (1) To determine whether the incidence of Bell’s Palsy (BP) increased during the pandemic. (2) To investigate whether the outcomes of patients with BP and COVID-19 infection or vaccination differ from those in the pre-pandemic era. Methods: Patients with BP were studied in 2 periods retrospectively (March 2021–March 2022 and August 2018–August 2019). A prospective study from March 2021 to March 2022 was also performed. Primary outcome was grade ≤Ⅱ in the House–Brackmann (HB) and/or >70 in the Sunnybrook facial grading system (SFGS) scales at the 12-week visit. Reverse transcriptase polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enzyme-linked immunosorbent assay-based SARS-CoV-2 immuonoglobulin G (IgG) test (blood) were measured. Results: About 162 and 196 patients with BP were identified between March 2021 and March 2022 and August 2018 and August 2019, respectively. Forty-seven patients (29%) entered the prospective study; 85% had HB grades I or II, while 92% had an SFGS score of 71-100 at the last visit. Only 3 patients (6.5%) had a positive PCR during the initial episode, whereas 35 patients (77%) had positive IgG SARS-CoV-2. There was no association between positive PCR and facial function outcomes. Of the 162 patients, 105 (67%) had received COVID-19 vaccine. In 23 of them (22%), the paralysis appeared within the first 30 days after a vaccine dose. Conclusion: Coronavirus disease 2019 did not increase the incidence of BP. A direct association between the coronavirus and BP outcome cannot be established. The considerable number of patients developing BP within the first month suggests a possible association between COVID-19 vaccines and BP.

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“…[ 33 ] A study from Karnataka has reported the prevalence of Bell's palsy among Covid-19 patients to be 0.8%. [ 34 ] This is significantly higher than the general population. The limitations of this study include small sample size, overrepresentation of severe cases which required hospitalization, a lack of statistical analysis, and an inability to establish causation.…”

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confidence: 96%