The supranutritional selenium status alters blood glucose and pancreatic redox homeostasis via a modulated selenotranscriptome in chickens (Gallus gallus)

Xiang, Li-Run; Li, Wei; Wang, Lili; Cao, Changyu; Li, Nan; Li, Xue-Nan; Jiang, Xiu-Qing; Li, Jinlong

doi:10.1039/c7ra02278f

Cited by 12 publications

(7 citation statements)

References 60 publications

(70 reference statements)

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“…insulin resistance, hyperglycemia, and high low-density lipoproteins. These results correspond to Xiang et al (2017) that additional Se as dietary feeding with high level (5 mg/ kg) was high blood glucose, whereas at lower concentration (3 mg/kg) lower blood glucose was observed.…”

Section: Discussionsupporting

confidence: 88%

Dietary supplementation of organic selenium to improve growth performance and protein utilization in African catfish fed with different protein level diets

Darmawangsa¹,

Suprayudi²,

Utomo³

et al. 2021

Jurnal Akuakultur Indonesia

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This study aimed to evaluate the effect of organic selenium supplementation on diet with different protein levels on the growth performance and protein utilization of African catfish juvenile. A randomized 2×3 factorial design with two dietary protein levels (27% and 32%) and three dietary selenium (Se) supplementation levels (0 mg/kg, 3 mg/kg, and 6 mg/kg diet) in triplicates were applied in the study. African catfish juvenile with an initial average body weight and body length of 27.00 ± 0.14 g and 15.0 ± 0.5 cm, respectively, was reared in 18 units of aquarium (141 L) at a density of 142 fish/m3 for a rearing period of 40 days. Increasing organic Se supplementation level up to 6 mg/kg at high protein feed resulted in higher fish growth and final biomass, lower FCR, and higher protein utilization efficiency than those of other treatments. Furthermore, supplementation of organic Se also resulted in lower lipid and higher Se concentrations in the fish body as well as higher blood protein level compared to those of the control. In conclusion, the result of this study suggested that dietary supplementation of organic Se up to 6 mg/kg could enhance the growth and protein utilization in African catfish fed with both low and high protein diet. Keywords: African catfish, growth, dietary protein, protein utilization, organic selenium. ABSTRAK Penelitian ini bertujuan mengevaluasi pengaruh suplementasi selenium organik pada pakan dengan kadar protein yang berbeda terhadap kinerja pertumbuhan dan pemanfaatan protein pakan ikan lele Clarias gariepenus. Penelitian didesain menggunakan rancangan acak lengkap faktorial 2×3 dengan dua tingkat protein pakan (27% dan 32%) dan tiga tingkat suplementasi selenium (Se) pakan (0 mg/kg, 3 mg/kg, dan 6 mg/kg diet) sebanyak tiga ulangan. Ikan lele yang digunakan memiliki bobot awal rata-rata dan panjang tubuh 27 ± 0.14 g dan 15.0 ± 0.5 cm, dipelihara dalam 18 unit akuarium (141 L) dengan kepadatan 142 ekor/m3 selama 40 hari pemeliharaan. Peningkatan suplementasi Se organik hingga 6 mg/kg pada ikan yang diberi pakan protein tinggi menghasilkan kinerja pertumbuhan ikan dan biomassa akhir yang lebih tinggi, FCR yang lebih rendah, dan efisiensi pemanfaatan protein pakan yang lebih tinggi daripada perlakuan lain. Selain itu, suplementasi Se organik juga menghasilkan kadar lemak yang lebih rendah dan konsentrasi Se tubuh yang lebih tinggi serta kadar protein darah yang lebih tinggi. Kesimpulan dari penelitian ini yaitu suplementasi Se organik pada pakan hingga 6 mg/kg dapat meningkatkan kinerja pertumbuhan dan pemanfaatan protein pakan pada ikan lele yang diberi pakan dengan kadar protein rendah dan tinggi. Kata kunci: ikan lele, pertumbuhan, protein pakan, pemanfaatan protein, selenium organik.

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Section: Discussionsupporting

confidence: 88%

Dietary supplementation of organic selenium to improve growth performance and protein utilization in African catfish fed with different protein level diets

Darmawangsa¹,

Suprayudi²,

Utomo³

et al. 2021

Jurnal Akuakultur Indonesia

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“…Moreover, 24 selenoproteins and associated transcription factors were influenced by Se intake in chickens’ pancreas. Selenium contributions to chicken development and regulation of blood sugar were associated with pancreatic redox homeostasis via a modulated selenotranscriptome [ 137 ]. Selenoprotein genes in spleen and thymus were down-regulated, inflammation-related genes were up-regulated due to supranutritional dietary Se status.…”

Section: Effects Of Selenium Supplementation In Chickenmentioning

confidence: 99%

Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins

et al. 2018

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Unlike other essential trace elements that interact with proteins in the form of cofactors, selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of 21st naturally occurring amino acid, selenocysteine (Sec), encoded by the UGA codon. Any protein that includes Sec in its polypeptide chain is defined as selenoprotein. Members of the selenoproteins family exert various functions and their synthesis depends on specific cofactors and on dietary Se. The Se intake in productive animals such as chickens affect nutrient utilization, production performances, antioxidative status and responses of the immune system. Although several functions of selenoproteins are unknown, many disorders are related to alterations in selenoprotein expression or activity. Selenium insufficiency and polymorphisms or mutations in selenoproteins’ genes and synthesis cofactors are involved in the pathophysiology of many diseases, including cardiovascular disorders, immune dysfunctions, cancer, muscle and bone disorders, endocrine functions and neurological disorders. Finally, heavy metal poisoning decreases mRNA levels of selenoproteins and increases mRNA levels of inflammatory factors, underlying the antagonistic effect of Se. This review is an update on Se dependent antioxidant enzymes, presenting the current state of the art and is focusing on results obtained mainly in chicken.

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“…The animal models play an important role in exploring the mechanisms associated with type 2 diabetes. Several studies have evaluated the influence of Se (IV) intake on blood glucose and insulin levels as well as pancreatic function in animal models [ 59 – 61 ]. In recent years, the scientific focus has been switched towards selenium nanoparticles as they have impressive therapeutic effects due to better production of reactive oxygen species in a dose-dependent manner, compared to selenite [ 62 , 63 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, it has to be noted that some studies showed a negative association between selenium and the symptoms of type 2 diabetes [ 78 ]. The increased blood glucose levels and the decrease in pancreatic antioxidant capacity were observed when chickens were fed with a high dose of selenite (5.0 mg/kg) for 8 weeks, but the opposite results were obtained when a lower dose (3 mg/kg) was applied [ 59 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium Species in Diabetes Mellitus Type 2

Pyrzynska,

Sentkowska

2023

Biol Trace Elem Res

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Selenium is an important trace element for humans and animals as it plays a key role in several major metabolic pathways. Several studies were conducted to better understand the role of selenium against diabetes mellitus (DM), particularly type 2 (T2DM), but the obtained conclusions are contradictory. A simple linear relationship does not exist between the risk of T2DM and selenium levels but is best represented in a dose-dependent manner, getting often the U-graph. This relation also depends on selenium chemical forms that are present in a diet or supplements. Both too low and too high selenium intakes could increase the risk of diabetes. Moreover, the baseline status of Se should be taken into consideration to avoid over-supplementation. The focus of this brief overview is to report the recent updates concerning selenium participation in diabetes mellitus.

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The supranutritional selenium status alters blood glucose and pancreatic redox homeostasis via a modulated selenotranscriptome in chickens (Gallus gallus)

Abstract: Dietary Se status stabilizes pancreatic normal physiology functionviathe regulation of the selenoprotemic transcriptions. Supranutritional or excess Se status alters the pancreatic redox homeostasisviamodulated selenotranscriptome.

Cited by 12 publications

References 60 publications

Dietary supplementation of organic selenium to improve growth performance and protein utilization in African catfish fed with different protein level diets

Dietary supplementation of organic selenium to improve growth performance and protein utilization in African catfish fed with different protein level diets

Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins

Selenium Species in Diabetes Mellitus Type 2

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