The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure

Sigurd, B; Olesen, Knud H.; Wennevold, A

doi:10.1016/0002-8703(75)90041-1

Cited by 65 publications

(27 citation statements)

References 12 publications

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“…Altogether, these studies confirm the hypothesis that during chronic administration of furosemide, an increased amount of NaCl is reabsorbed in the thiazide-sensitive nephron segment. This also explains the supra-additive natriuretic synergism between acute thiazide and chronic furosemide administration which was originally suggested by Olesen and Sigurd (Olesen & 14 J0RGEN S0BERG PETERSEN Sigurd 1971: Sigurd et al 1975Sigurd & Olesen 1977;Brater et al 1985;Loon et al 1989;Fliser et al 1994). In a carefully controlled study using a computer-driven servocontrolled technique (Burgess et al 1993) to clamp extracellular-fluid volume during acute administration of furosemide and bendroflumethiazide, we later confirmed this synergism in conscious rats (Jonassen et ul.…”

Section: Renal Adaptations During Furosemide Administrationmentioning

confidence: 51%

Interactions Between Furosemide and the Renal Sympathetic Nerves

Petersen¹

1999

Pharmacology & Toxicology

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Section: Renal Adaptations During Furosemide Administrationmentioning

confidence: 51%

Interactions Between Furosemide and the Renal Sympathetic Nerves

Petersen¹

1999

Pharmacology & Toxicology

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“…The combination treatment o f furosemide-thiazidetype diuretics has been reported to be effective in several clinical situations such as congestive heart failure and Nakahama/Orita/Yamazaki/ltoh/Okuda/Yamaji/Miwa/Yanase/Fukuhara/Kamada T im e , h other edematous diseases [2][3][4]. Isolated clinical reports are frequent, but only a few well-monitored studies are available [5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been several reports on the effec tiveness o f adding thiazide-type diuretics to furosemide in refractory edema [2][3][4], only a few well-monitored pharmacokinetic studies are available. Furthermore, those studies have been performed only in animals or in normal volunteers [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic Interactions between Furosemide and Hydrochlorothiazide in Nephrotic Patients

Nakahama

Orita

Yamazaki

et al. 1988

Nephron

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We examined the response of 8 patients with nephrotic syndrome (creatinine clearance 70.4 ± 16.0 ml/ min) to oral furosemide (F; 40 mg) in the absence (control) and in the presence of oral hydrochlorothiazide (HCT; 100 mg). In the 24-hour period after oral F, HCT was shown to increase urine volume and urinary sodium and chloride excretion. Increment was most significant during the 12- to 24- hour period. Enhancement of the diuresis with HCT was associated neither with a significant increase in the area under the curve of plasma F concentration nor an increase in urinary F excretion. Urinary excretion of glucuronidated F, one of the main metabolites of F, however, was decreased with HCT. In summary, HCT significantly enhanced the response to F in nephrotic patients.

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“…Synergistic mechanisms of thiazide and loop diuretics have been proposed that rebound augmentation of sodium reabsorption in the distal renal tubule with the declining effects of loop diuretics might be inhibited by thiazide. [13][14][15] In accordance with this postulate, we administered hydrochlorothiazide in divided doses, not in a single dose, after infusion of furosemide. Although the interval needed for the complete washout of hemodynamic effects caused by diuretics may be longer, we established it at 48 h (including a second baseline data collection period) for the safety and compliance of our patients.…”

Section: Transl Clin Pharmacolmentioning

confidence: 99%