The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors

Du, Chao; Li, Yingchao; Guo, Yahui; Han, Mei; Zhang, Weiguo; Qian, He

doi:10.1016/j.bbrc.2015.12.112

Cited by 46 publications

(33 citation statements)

References 23 publications

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“…In addition to antioxidant activity, in vivo anti-cancerous properties of the two carotenoids have also been demonstrated. In the anti-cancer supplementation experiments, compared to lycopene, both torulene and torularhodin performed much more significant inhibition of the growth of prostate cancer in nude mice by the induction of apoptosis of tumor cells [21]. Furtherly, it was confirmed that both of them facilitated protective activity on human prostate stromal cells from oxidative stress damage [22].…”

Section: Torulene and Torularhodinmentioning

confidence: 92%

Biosynthetic Pathway of Carotenoids in Rhodotorula and Strategies for Enhanced Their Production

Tang¹,

Wang²,

Jun³

et al. 2019

Journal of Microbiology and Biotechnology

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Rhodotorula is a group of pigment-producing yeasts well known for its intracellular biosynthesis of carotenoids such as β-carotene, γ-carotene, torulene and torularhodin. The great potential of carotenoids in applications in food and feed as well as in health products and cosmetics has generated a market value expected to reach over $2.0 billion by 2022. Due to growing public concern over food safety, the demand for natural carotenoids is rising, and this trend significantly encourages the use of microbial fermentation for natural carotenoid production. This review covers the biological properties of carotenoids and the most recent findings on the carotenoid biosynthetic pathway, as well as strategies for the metabolic engineering methods for the enhancement of carotenoid production by Rhodotorula. The practical approaches to improving carotenoid yields, which have been facilitated by advancements in strain work as well as the optimization of media and fermentation conditions, were summarized respectively.

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Section: Torulene and Torularhodinmentioning

confidence: 92%

Biosynthetic Pathway of Carotenoids in Rhodotorula and Strategies for Enhanced Their Production

Tang¹,

Wang²,

Jun³

et al. 2019

Journal of Microbiology and Biotechnology

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“…This carotenoid exhibits strong antioxidant activity, acts as a vitamin A precursor, and has been proposed as a colorant for meat products due to its characteristic red color (Moliné, Libkind, & van Broock, 2012;Zoz, Carvalho, Soccol, Casagrande, & Cardoso, 2015). Recently, the anticancer potential of torularhodin has been demonstrated in vivo on mice (Du et al, 2016). Another natural carotenoid, zeaxanthin, plays a critical role in the prevention of age-related eye diseases such as macular degeneration and cataracts.…”

Section: Pigmentsmentioning

confidence: 99%

Pulsed electric field‐assisted extraction of valuable compounds from microorganisms

Martínez

Delso

Álvarez

et al. 2020

Comp Rev Food Sci Food Safe

113

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Microorganisms (bacteria, yeast, and microalgae) are a promising resource for products of high value such as nutrients, pigments, and enzymes. The majority of these compounds of interest remain inside the cell, thus making it necessary to extract and purify them before use. This review presents the challenges and opportunities in the production of these compounds, the microbial structure and the location of target compounds in the cells, the different procedures proposed for improving extraction of these compounds, and pulsed electric field (PEF)‐assisted extraction as alternative to these procedures. PEF is a nonthermal technology that produces a precise action on the cytoplasmic membrane improving the selective release of intracellular compounds while avoiding undesirable consequences of heating on the characteristics and purity of the extracts. PEF pretreatment with low energetic requirements allows for high extraction yields. However, PEF parameters should be tailored to each microbial cell, according to their structure, size, and other factors affecting efficiency. Furthermore, the recent discovery of the triggering effect of enzymatic activity during cell incubation after electroporation opens up the possibility of new implementations of PEF for the recovery of compounds that are bounded or assembled in structures. Similarly, PEF parameters and suspension storage conditions need to be optimized to reach the desired effect. PEF can be applied in continuous flow and is adaptable to industrial equipment, making it feasible for scale‐up to large processing capacities.

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“…Studies of toxicity conducted on rats demonstrated that b-carotene, TRo and TRu produced by R. glutinis yeasts can be used as innocuous food additives (Latha & Jeevaratanm, 2012). Also, TRu and TRo could be able to inhibit growth of prostate cancer (Du et al, 2016). On the other hand, phytoene was quantified in low concentration in CSÀDPA, but it was undetectable in CS+DPA, suggesting that phytoene acts as precursor being immediately metabolised to others carotenoids.…”

Section: Profile and Quantification Of Carotenoids By Hplc-dadmentioning

confidence: 98%

Carotenoid profile produced by Bacillus licheniformis Rt4M10 isolated from grapevines grown in high altitude and their antioxidant activity

Cohen

Dichiara

Jofré

et al. 2018

Int J of Food Sci Tech

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Summary Bacillus licheniformis (BL) strains are used for industrial production of exoenzymes, antibiotics and secondary metabolites, and also serve as probiotics. Some strains sequester heavy metals, promoting plant growth or inducing plant systemic resistance against stresses. However, investigations on the biological functions and applicability of carotenoids produced by BL had been less studied. In this study, the carotenoid profile produced by BL Rt4M10 was characterised during the accumulation period of culture and in response to diphenylamine (DPA), inhibitor of carotenoid biosynthesis. The antioxidant scavenging capacities of the carotenoid extracts against oxidative reactions inside the microbial cell and in vitro were also evaluated. Eighteen different carotenoids were analysed; their profile was modified along bacterial growth. DPA decreased carotenoid production by 70%, as well as the cells’ survival in hydrogen peroxide and the antioxidant capacity, thus demonstrating the role of carotenoids from Rt4M10 in oxidative stress.

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The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors

Cited by 46 publications

References 23 publications

Biosynthetic Pathway of Carotenoids in Rhodotorula and Strategies for Enhanced Their Production

Biosynthetic Pathway of Carotenoids in Rhodotorula and Strategies for Enhanced Their Production

Pulsed electric field‐assisted extraction of valuable compounds from microorganisms

Carotenoid profile produced by Bacillus licheniformis Rt4M10 isolated from grapevines grown in high altitude and their antioxidant activity

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