The suppression of IL-17 production from T cells by gallate-type procyanidin is mediated by selectively inhibiting cytokine production from dendritic cells

Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy

“…In this experiment, LPC treatment decreased the number of TAMs in TME, inhibited their activators like LPS and IFN-γ [ 27 , 38 ], and reduced the levels of inflammatory factors, such as NF-κB p65, TNF-α, and IL-1β. As previous reported, NF-κB p65, IL-1β and TNF-α, as key signaling molecules, induced the production of IL-17 [ 39 ], which promoted the proliferation and metastasis of colon cancer [ 40 ]. Transcriptome analysis indicated that LPC could significantly inhibit IL-17 signaling pathway.…”

Halofuginone-guided nano-local therapy: Nano-thermosensitive hydrogels for postoperative metastatic canine mammary carcinoma with scar removal

“…Related study has demonstrated by activating the integrated stress response (IRS), the halofuginone activated the amino acid starvation response (AAR), which selectively inhibited activation of the Th17 cell in mice ( Sundrud et al, 2009 ). As a result, the inflammatory factor secretion from Th17 cells was presumably suppressed and inflammation was reduced because the inflammatory factor secretion decreased ( Endo et al, 2021 ). Th17 cells induce multiple inflammations and exert hematopoietic effects by secreting secrete cytokines such as IL-17A, IL-17F, IL-21, IL-22, and IL-23.…”

Concise Synthesis of Procyanidin B2 3,3′′-Digallate Using Yb(OTf)3-Mediated Self-Condensation

“…Some proanthocyanidins possess gallate groups, which show significant biological activity. [6][7][8] Synthetic examples of procyanidin gallate have been reported; 9,10 however, efficient synthetic methods are very limited. We also reported the synthesis of procyanidin B2 3,3′′-digallate using equimolar condensation (Figure 1).…”