The suppression of heterotopic ossifications

Sell, Stefan; Willms, Rhonda; Jany, R.; Esenwein, S. A.; Gaissmaier, C.; Martini, F.; Bruhn, G.; Burkhardsmaier, F.; Bamberg, M.; Küsswetter, W.

doi:10.1016/s0883-5403(98)90189-9

Cited by 74 publications

(12 citation statements)

References 26 publications

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“…Postoperative radiation after hip replacements prevents conversion of precursor cells to bone-forming cells. 10) To our knowledge, no study is reported that describes the effect of either radiation therapy or NSAIDs specifically on HOs in the shoulder joints. In the literature regarding hip implant related HOs (severe grade III/IV), those treated with RT are marginally more effectively prevented than with NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Scapulohumeral Ankylosis after Prolonged Mechanical Ventilation

et al. 2016

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This case demonstrates a rarely reported bilateral scapulohumeral bony ankylosis. A young woman developed extensive heterotopic ossifications (HOs) in both shoulder joints after being mechanically ventilated for several months at the intensive care unit in a comatose status. She presented with a severe movement restriction of both shoulder joints. Surgical resection of the bony bridges was performed in 2 separate sessions with a significant improvement of shoulder function afterwards. No postoperative complications, pain, or recurrence of HOs were noted at 1-year follow-up. Mechanical ventilation, immobilization, neuromuscular blockage, and prolonged sedation are known risk factors for the development of HOs in the shoulder joints. Relatively early surgical resection of the HOs can be performed safely in contrary to earlier belief. Afterwards, nonsteroidal anti-inflammatory drugs and/or radiation therapy can be possible treatment modalities to prevent recurrence of HOs.

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Section: Discussionmentioning

confidence: 99%

Bilateral Scapulohumeral Ankylosis after Prolonged Mechanical Ventilation

et al. 2016

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“…It does so by interfering with and suppressing mesenchymal‐cell progression to osteogenic cells 15, 22, 68. Preoperatively, RT delivery has shown varied reports of effectiveness 2.…”

Section: Prevention: Radiationmentioning

confidence: 99%

Treatments and Preventative Measures for Trauma‐Induced Heterotopic Ossification: A Review

Juarez

Wenke

Rivera

2018

Clinical Translational Sci

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“…Radiating pluripotential mesenchymal cells, the possible osteoprogenitor cells for HO, may effectively prevent the formation of HO [155]. Unfortunately, the NSAID therapy, while reasonably effective, has side-effects, most notably gastrointestinal ulceration, decreased platelet aggregation and renal toxicity [154, 156]. Since BMPs are well-established inducers of the HO, BMP inhibitors might turn out to be useful in the prevention of HO in the future.…”

Section: Bmp Signaling In Heterotopic Ossificationmentioning

confidence: 99%

Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy

Shi

Gorter

Hoogaars

et al. 2012

Cell. Mol. Life Sci.

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Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this review, we will summarize the recent progress in elucidation of BMP signal transduction, how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy, and discuss possible therapeutic strategies for treatment of these diseases.

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The suppression of heterotopic ossifications

Cited by 74 publications

References 26 publications

Bilateral Scapulohumeral Ankylosis after Prolonged Mechanical Ventilation

Bilateral Scapulohumeral Ankylosis after Prolonged Mechanical Ventilation

Treatments and Preventative Measures for Trauma‐Induced Heterotopic Ossification: A Review

Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy

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