The Suppression of Crossing Over in Inversion Heterozygotes of Drosophila Pseudoobscura

Dobzhansky, Theodosius; Epling, Carl

doi:10.1073/pnas.34.4.137

Cited by 82 publications

(60 citation statements)

References 3 publications

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“…Heterozygous inversions also inhibit crossing-over in the region of the inverted segments in the Nearctic species of Drosophila. This was well shown by Carson in D. robusta (1953), Dobzhansky and Epling (1948) in D. pseudoobscura, Sturtevant and Beadle (1936) in D. melanogaster, Komai andTakaku (1940, 1942) in D. virilis, and others. Recombination between homologues would be extremely rare in a large number of natural populations of D. willistoni if its inversions had the same suppressive effect on crossing-over outside the inverted segment.…”

Section: Discussionsupporting

confidence: 63%

Recombination in Drosophila willistoni

1968

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Section: Discussionsupporting

confidence: 63%

Recombination in Drosophila willistoni

1968

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“…Chromosome number and recombination rate are strongly positively correlated across mammalian taxa (Dutrilleux 1986;Burt and Bell 1987;Pardo-Manuel de Villena and Sapienza 2001), and inversion heterozygosity can suppress recombination throughout inverted regions (Dobzhansky and Epling 1948). In addition, recombination rates vary predictably across a range of genomic contexts, including base composition, position relative to telomeres and centromeres, gene density, and repetitive elements (Kong et al 2002;Jensen-Seaman et al 2004;Myers et al 2005;Shifman et al 2006;Coop et al 2008).…”

Section: Detection Of Map Length Differencesmentioning

confidence: 99%

Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps

Dumont¹,

White²,

Steffy³

et al. 2010

Genome Res.

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The rate of recombination is a key genomic parameter that displays considerable variation among taxa. Species comparisons have demonstrated that the rate of evolution in recombination rate is strongly dependent on the physical scale of measurement. Individual recombination hotspots are poorly conserved among closely related taxa, whereas genomic-scale recombination rate variation bears a strong signature of phylogenetic history. In contrast, the mode and tempo of evolution in recombination rates measured on intermediate physical scales is poorly understood. Here, we conduct a detailed statistical comparison between two whole-genome F 2 genetic linkage maps constructed from experimental intercrosses between closely related house mouse subspecies (Mus musculus). Our two maps profile a common wild-derived inbred strain of M. m. domesticus crossed to distinct wild-derived inbred strains representative of two other house mouse subspecies, M. m. castaneus and M. m. musculus. We identify numerous orthologous genomic regions with significant map length differences between these two crosses. Because the genomes of these recently diverged house mice are highly collinear, observed differences in map length (centimorgans) are suggestive of variation in broadscale recombination rate (centimorgans per megabase) within M. musculus. Collectively, these divergent intervals span 19% of the house mouse genome, disproportionately aggregating on the X chromosome. In addition, we uncover strong statistical evidence for a large effect, sex-linked, site-specific modifier of recombination rate segregating within M. musculus. Our findings reveal considerable variation in the megabase-scale recombination landscape among recently diverged taxa and underscore the continued importance of genetic linkage maps in the post-genome era.

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“…In addition, however, the gene or gives some information about the third chromosome. Since some crossing over occurs in D. pseudoobscura despite the presence of even moderately long or complex inversions on the same chromosome (Dobzhansky and Epling, 1948 ; R. P. Levine, 1956;Sturtevant and Dobzhansky, 1936;Dobzhansky and Sturtevant, 1938 ; also see below), X and second chromosomes, cytologically of one species, may in fact contain some genes of the other. The strains of the species used differ cytologically by an inversion on each arm of the X chromosome and one on the rodshaped second chromosome.…”

Section: Chromosome Frequenciesmentioning

confidence: 99%

Introgression in laboratory populations of Drosophila persimilis and D. pseudoobscura

Valen

1963

Heredity

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The Suppression of Crossing Over in Inversion Heterozygotes of Drosophila Pseudoobscura

Cited by 82 publications

References 3 publications

Recombination in Drosophila willistoni

Recombination in Drosophila willistoni

Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps

Introgression in laboratory populations of Drosophila persimilis and D. pseudoobscura

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