The superior temporal sulcus performs a common function for social and speech perception: Implications for the emergence of autism

Redcay, Elizabeth

doi:10.1016/j.neubiorev.2007.06.004

Cited by 289 publications

(249 citation statements)

References 165 publications

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“…The MTG cluster included the superior temporal sulcus, which is associated with social cognition, and dysfunctional in autism (Zilbovicius et al, 2006). Our interpretation is that MTG plays a central role in elaborating little scenarios, on a visual basis, that naturally take place when understanding concrete sentences describing people's actions (Redcay, 2008).…”

Section: Discussionmentioning

confidence: 81%

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Vidal¹,

Freyermuth²,

Jerbi³

et al. 2012

J. Neurosci.

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Reading sentences involves a distributed network of brain regions acting in concert surrounding the left sylvian fissure. The mechanisms of neural communication underlying the extraction and integration of verbal information across subcomponents of this reading network are still largely unknown. We recorded intracranial EEG activity in 12 epileptic human patients performing natural sentence reading and analyzed long-range corticocortical interactions between local neural activations. During a simple task contrasting semantic, phonological, and purely visual processes, we found process-specific neural activity elicited at the single-trial level, characterized by energy increases in a broad gamma band (40 -150 Hz). Correlation analysis between task-induced gamma-band activations revealed a selective fragmentation of the network into specialized subnetworks supporting sentence-level semantic analysis and phonological processing. We extend the implications of our results beyond reading, to propose that gamma-band amplitude correlations might constitute a fundamental mechanism for large-scale neural integration during high-level cognition.

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Section: Discussionmentioning

confidence: 81%

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Vidal¹,

Freyermuth²,

Jerbi³

et al. 2012

J. Neurosci.

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“…Studies of autistic patients have emphasized that specific brain regions, linked to empathy and TOM deficits, showed reduced activity at rest (Kennedy and Courchesne, 2008) and under activation condition (Kennedy and Courchesne, 2008;Redcay, 2008;Thakkar et al, 2008).…”

Section: Brain Imaging In the Prader-willi Syndromementioning

confidence: 99%

PET Scan Perfusion Imaging in the Prader–Willi Syndrome: New Insights into the Psychiatric and Social Disturbances

Mantoulan

Payoux

Diene

et al. 2010

J Cereb Blood Flow Metab

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The Prader-Willi syndrome (PWS), a rare multisystem genetic disease, leads to severe disabilities, such as morbid obesity, endocrine dysfunctions, psychiatric disorders, and social disturbances. We explored the whole brain of patients with PWS to detect abnormalities that might explain the behavioral and social disturbances, as well as the psychiatric disorders of these patients. Nine patients with PWS (six males, three females; mean age 16.4 years) underwent a positron emission tomography (PET) scan with H 2 15 O as a tracer to measure regional cerebral blood flow (rCBF). The images were compared with those acquired from nine controls (six males, three females; mean age 21.2 years). A morphologic magnetic resonance imaging (MRI) was also performed in PWS patients, and their cognitive and behavioral skills were assessed with Wechsler Intelligence Scale for Children III and the Child Behavior Check List (CBCL). The MRI images showed no evident anatomic abnormalities, whereas PET scans revealed hypoperfused brain regions in PWS patients compared with controls, particularly in the anterior cingulum and superior temporal regions. We observed a significant relationship (P < 0.05) between rCBF in the hypoperfused regions and CBCL scores. The functional consequences of these perfusion abnormalities in specific brain regions might explain the behavioral and social problems observed in these individuals.

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“…This has been observed in the posterior superior temporal sulcus (pSTS), with high scorers on the AQ demonstrating reduced white matter volume (Von Dem Hagen, Nummenmaa, Yu, Engell, Ewbank & Calder, 2011). The STS is implicated in social cognition, and there is evidence that differences in this brain region could underlie the differences observed in those with ASD and typically developing controls (Redcay, 2008). In terms of sensory processing, it has been recently demonstrated that high-and low-scorers on the AQ perform differently on a variety of visual processing tasks.…”

mentioning

confidence: 99%

The Relationship between Sensory Sensitivity and Autistic Traits in the General Population

Robertson

Simmons

2012

J Autism Dev Disord

341

377

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The superior temporal sulcus performs a common function for social and speech perception: Implications for the emergence of autism

Cited by 289 publications

References 165 publications

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

PET Scan Perfusion Imaging in the Prader–Willi Syndrome: New Insights into the Psychiatric and Social Disturbances

The Relationship between Sensory Sensitivity and Autistic Traits in the General Population

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