The <sup>13</sup>C‐caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy

Park, G. J.-H.; Katelaris, Peter; Jones, D. Brian; Seow, Francis; Lin, Brian; Couteur, David G. Le; Ngu, Meng C.

doi:10.1111/j.1365-2036.2005.02623.x

Cited by 26 publications

(28 citation statements)

References 38 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus noninvasive techniques are awaited to predict advanced or progressive forms of liver diseases, and for better selection of patients in whom a liver biopsy might be indicated in an area where basal levels are often normal [37]. In this regard, stable isotope breath tests have shown promising results in predicting fibrosis and response to therapy in patients with viral liver diseases [38]. In this respect, the role of breath tests were investigated in the present study.…”

Section: Discussionmentioning

confidence: 98%

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

et al. 2006

View full text Add to dashboard Cite

Effectively assessing subtle hepatic metabolic functions by novel non-invasive tests might be of clinical utility in scoring NAFLD (non-alcoholic fatty liver disease) and in identifying altered metabolic pathways. The present study was conducted on 39 (20 lean and 19 obese) hypertransaminasemic patients with histologically proven NAFLD {ranging from simple steatosis to severe steatohepatitis [NASH (non-alcoholic steatohepatitis)] and fibrosis} and 28 (20 lean and eight overweight) healthy controls, who underwent stable isotope breath testing ([(13)C]methacetin and [(13)C]ketoisocaproate) for microsomal and mitochondrial liver function in relation to histology, serum hyaluronate, as a marker of liver fibrosis, and body size. Compared with healthy subjects and patients with simple steatosis, NASH patients had enhanced methacetin demethylation (P=0.001), but decreased (P=0.001) and delayed (P=0.006) ketoisocaproate decarboxylation, which was inversely related (P=0.001) to the degree of histological fibrosis (r=-0.701), serum hyaluronate (r=-0.644) and body size (r=-0.485). Ketoisocaproate decarboxylation was impaired further in obese patients with NASH, but not in patients with simple steatosis and in overweight controls. NASH and insulin resistance were independently associated with an abnormal ketoisocaproate breath test (P=0.001). The cut-off value of 9.6% cumulative expired (13)CO(2) for ketoisocaproate at 60 min was associated with the highest prediction (positive predictive value, 0.90; negative predictive value, 0.73) for NASH, yielding an overall sensitivity of 68% and specificity of 94%. In conclusion, both microsomal and mitochondrial functions are disturbed in NASH. Therefore stable isotope breath tests may usefully contribute to a better and non-invasive characterization of patients with NAFLD.

show abstract

Section: Discussionmentioning

confidence: 98%

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Enrichment of breath 13-CO 2 can thereby be used to calculate the hepatic metabolism of caffeine. This system, which is similar in concept to the aminopyrine breath test, has been studied in the setting of chronic hepatitis B virus (HBV) infection [47] and steato-hepatitis [48], and the results correlate with other parameters of hepatic function and fibrosis (at least in distinguishing cirrhotic from noncirrhotic disease). Alterations in caffeine and aminopyrine metabolism in cirrhosis may be hypothesized to occur due to altered first-pass metabolism rather than solely as a result of hepatocyte dysfunction.…”

Section: Noninvasive Assessment Of Liver Function and Fibrosis: Utilimentioning

confidence: 99%

The Precarious State of the Liver After a Fontan Operation: Summary of a Multidisciplinary Symposium

et al. 2012

View full text Add to dashboard Cite

As the cohort of survivors with the single-ventricle type of congenital heart disease grows, it becomes increasingly evident that the state of chronically elevated venous pressure and decreased cardiac output inherent in the Fontan circulation provides the substrate for a progressive decline in functional status. One organ at great risk is the liver. Wedged between two capillary beds, with the pulmonary venous bed downstream, which typically has no pulsatile energy added in the absence of a functional right ventricle, and the splanchnic bed upstream, which may have compromised inflow due to inherent cardiac output restriction characteristic of the Fontan circulation, the liver exists in a precarious state. This review summarizes a consensus view achieved at a multidisciplinary symposium held at The Children’s Hospital of Philadelphia in June 2011. The discussion includes current knowledge concerning the hemodynamic foundations of liver problems, the diagnostic tools available, the unique histopathology of the liver after the Fontan operation, and proposed mechanisms for hepatic fibrosis at the cellular level. At the completion of the symposium, a consensus recommendation was made by the authors’ group to pursue a new prospective protocol for clinical evaluation of the liver for all patients in our practice 10 years after the Fontan operation.

show abstract

“…Besides these markers, transient elastography, 13C-caffeine breath test, and DNA sequencedbased serum protein glycomics have also been proposed for the evaluation of liver fibrosis in chronic liver diseases (26)(27)(28). However, many of these tests are not widely available, and nonspecifically elevated in the presence of various circumstances.…”

Section: Discussionmentioning

confidence: 97%

Serum prolidase enzyme activity and its relation to histopathological findings in patients with non‐alcoholic steatohepatitis

Horoz

Aslan

Bolukbas

et al. 2010

Clinical Laboratory Analysis

View full text Add to dashboard Cite

The aim of this study was to investigate serum prolidase enzyme activity and to find out its association with liver biopsy specimens' histopathological findings in patients with nonalcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis. Thirty-six patients with biopsy-proven NASH and 29 healthy controls were enrolled. Serum prolidase enzyme activity was measured spectrophotometrically. Serum prolidase enzyme activity was significantly higher in patients with NASH than controls (P=0.016). A significant correlation was observed between serum prolidase enzyme activity and fibrosis score in patients with NASH (r=0.661, P<0.001). Serum prolidase activity seems to be correlated with the level of fibrosis. Monitoring serum prolidase activity may be a useful adjunctive tool in predicting liver fibrosis, especially in the absence of advanced fibrosis and other conditions, which may affect the interpretation of prolidase activity.

show abstract

The ¹³C‐caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy

Abstract: SUMMARY Background:The 13 C-caffeine breath test is a non-

Cited by 26 publications

References 38 publications

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

The Precarious State of the Liver After a Fontan Operation: Summary of a Multidisciplinary Symposium

Serum prolidase enzyme activity and its relation to histopathological findings in patients with non‐alcoholic steatohepatitis

Contact Info

Product

Resources

About

The 13C‐caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy

Abstract: SUMMARY Background:The 13 C-caffeine breath test is a non-

Cited by 26 publications

References 38 publications

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

The Precarious State of the Liver After a Fontan Operation: Summary of a Multidisciplinary Symposium

Serum prolidase enzyme activity and its relation to histopathological findings in patients with non‐alcoholic steatohepatitis

Contact Info

Product

Resources

About

The ¹³C‐caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy