The summary and preliminary analysis of clinical and PET/CT features of patients with intestinal metastasis of primary lung cancer

Abstract

Purpose This study aimed to analyze the influence of clinical manifestation, PET/CT parameters, and treatment on the prognosis of patients with primary lung cancer who developed intestinal metastasis. Method We collected data from 21 cases of primary lung cancer with intestinal metastasis. The data included basic information, examination results, treatment processes, and prognosis. We employed Kaplan-Meier (K-M) analysis, multivariate Cox regression analysis, and t-test for prognosis analysis. Results Intestinal obstruction and advanced stage were associated with poor progression-free survival (PFS) (P = 0.017 and 0.038, respectively). Smoking, intestinal obstruction, and the lack of chemotherapy were associated with worse overall survival (OS) (P = 0.043, 0.021, 0.013, respectively). Anti-PD-1 therapy (P = 0.006) and pneumonectomy (P = 0.007) improved patient outcomes. The immunohistochemical results showed no correlation between these markers and prognosis (P > 0.05). The mean SUVmax of intestinal metastases (10.23 ± 3.59) was higher than that of primary lung cancer (7.57 ± 3.42), and the former was also higher than the latter in both death and survival groups. There was no significant correlation between PET parameters (SUVmax, TLG, MTV) and prognosis (P > 0.05). Conclusion Smoking, intestinal obstruction, advanced stage, and lack of chemotherapy were risk factors for poor outcomes in primary lung cancer with intestinal metastasis. Patients treated with anti-PD-1 therapy and pneumonectomy tended to have better outcomes. The mean SUVmax of intestinal metastases was higher than that of primary lung cancer.