The Sulpiride Test in Panhypopituitarism

Batrinos, Menelaos L.; Pavlou, Sp.; Pitoulis, Spyros; Sfikaki, A. P.; Alexandrides, Theodore K.; Piaditis, Georgios

doi:10.1111/j.1365-2265.1978.tb01494.x

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…A gross blunting of responsiveness was apparent on the second day of each test period throughout the study. Batrinos et al (1978) reported that the response of PRL to sulpiride stimulation was greater than that reported following other provocation tests of this hormone. Repeated sulpiride stimulation was reported to give a comparable PRL response at a ten day interval and a higher response at a five day interval.…”

Section: Resultsmentioning

confidence: 80%

Prolactin Responsiveness to Repeated Decremental Doses of Sulpiride

Tormey¹,

Buckley²,

Taaffe³

et al. 1981

Horm Metab Res

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The variation in the prolactin response to sulpiride was studied in six normal men by repeating the same dose of the drug (50 mg) after 24 hours and on three subsequent occasions, repeating this 2 day test at an interval of 6 days with progressively halved doses of sulpiride. A similar PRL response occurred on the first day of each test period and the peak response was highly significant (P less than 0.001), occurring within 30 minutes. A gross blunting of the PRL response on the second day of each period was noted throughout the study. The difference in delta PRL between the first and second day of each period was highly significant (P less than 0.001). The delta PRL increment on the second day was inversely proportional to the dose of sulpiride; the differences in delta PRL between periods 1 and 3 and periods 1 and 4 being highly significant (P less than 0.001). This study suggests that a much lower dose of sulpiride than that normally used is adequate to stimulate PRL secretion and that care must be taken in the timing of repeat testing.

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Section: Resultsmentioning

confidence: 80%

Prolactin Responsiveness to Repeated Decremental Doses of Sulpiride

Tormey¹,

Buckley²,

Taaffe³

et al. 1981

Horm Metab Res

View full text Add to dashboard Cite

show abstract

“…The details of the test are described in the preceding paper (Batrinos et al, 1978). Statistical evaluation of the results was made by the Wilcoxon-White test (Snedecor & Cochran, 1967).…”

Section: Methodsmentioning

confidence: 99%

Assessment of Prolactin Release in Pituitary Dwarfism With the Sulpiride Test

Batrinos

Pavlou

Pitoulis

et al. 1978

Clinical Endocrinology

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We report here the results obtained with a new test of prolactin (PRL) release in six normal pre-pubertal boys, eleven children with short stature of non-pituitary origin and in thirteen pituitary dwarfs. The test consists of the administration of 100 mg of sulpiride i.m. and the measurement of PRL in serum samples up to 120 min after injection. Baseline PRL concentrations were not clearly different in the three groups. After sulpiride a marked increase (3--10 times over control values) in PRL was noted in all normal and short children without pituitary disease. A complete failure of response was observed in ten of the thirteen pituitary dwarfs. It is concluded that sulpiride has considerable potential in the differential diagnosis of children with stunted growth.

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Pituitary Function Tests in Sheehan's Syndrome

Shahmanesh

Ali

Pourmand

et al. 1980

Clinical Endocrinology

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Fourteen patients with a typical history of Sheehan's syndrome underwent pituitary function tests with simultaneous injections of 100 micrograms LH-RH, 200 micrograms TRH and 0.05--0.1 units of soluble insulin per kg body weight. Serum prolactin levels remained unchanged in all of eleven subjects given TRH. GH levels did not rise after hypoglycaemia in five subjects. In contrast serum LH and FSH rose significantly in twelve out of fourteen subjects given LHRH and serum TSH rose significantly in five out of seven subjects given TRH. It is concluded that pituitary function is relatively preserved for LH and FSH but not for prolactin and GH in Sheehan's syndrome. It is further suggested that absence of a rise in prolactin following TRH stimulation may provide the most sensitive test of pituitary hypofunction in postpartum haemorrhage.

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The Sulpiride Test in Panhypopituitarism

Cited by 4 publications

References 5 publications

Prolactin Responsiveness to Repeated Decremental Doses of Sulpiride

Prolactin Responsiveness to Repeated Decremental Doses of Sulpiride

Assessment of Prolactin Release in Pituitary Dwarfism With the Sulpiride Test

Pituitary Function Tests in Sheehan's Syndrome

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