The suitability of the GERDyzer instrument in pH-test-proven laryngopharyngeal reflux patients

Wu, Cheng-Pin; Liang, Wen‐Miin; Wang, Chen‐Chi; Chang, Chung‐Hsing; Yeh, Hong‐Zen; Hsu, Jeng-Yuan; Ko, Chung‐Wang; Lee, Shou-Wu; Chang, Shang‐Tzen; Sung, Fung‐Chang; Lien, Han‐Chung

doi:10.1097/md.0000000000004439

Cited by 3 publications

(2 citation statements)

References 39 publications

(60 reference statements)

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“…Twenty-four-hour pH monitoring of the hypopharynx and esophagus is the gold standard for the diagnosis of LPRD[ 37 ]. A catheter with a pH monitoring probe is placed at the lower end of the esophagus through the patient’s nose and oropharynx, and the catheter is fixed to monitor reflux and removed on the next day.…”

Section: Clinical Features and Diagnosis Of Lprdmentioning

confidence: 99%

Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease

Cui,

Dai,

Liu

et al. 2024

World J Gastroenterol

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Laryngopharyngeal reflux disease (LPRD) is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the esophagus. LPRD commonly presents with sym-ptoms such as hoarseness, cough, sore throat, a feeling of throat obstruction, excessive throat mucus. This complex condition is thought to involve both reflux and reflex mechanisms, but a clear understanding of its molecular mechanisms is still lacking. Currently, there is no standardized diagnosis or treatment protocol. Therapeutic strategies for LPRD mainly include lifestyle modifications, proton pump inhibitors and endoscopic surgery. This paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms, patho-physiology and treatment of LPRD. We also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

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Section: Clinical Features and Diagnosis Of Lprdmentioning

confidence: 99%

Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease

Cui,

Dai,

Liu

et al. 2024

World J Gastroenterol

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“…LPR is a prevalent disease which was estimated to be 10% of the outpatients in the otolaryngology units [1]. The quality of life of LPR patients is generally poor [4]; however, the management is challenging. Traditionally, using empirical proton pump inhibitors (PPIs) once or twice daily is often a pragmatic therapeutic strategy and those who are refractory to high dose PPIs treatment are recommended to refer for the reflux testing [5].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Laryngopharyngeal Reflux: Past, Present, and Future—A Mini-Review

2023

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Laryngopharyngeal reflux (LPR) is a variant of gastroesophageal reflux disease (GERD) in which gastric refluxate irritates the lining of the aerodigestive tract and causes troublesome airway symptoms or complications. LPR is a prevalent disease that creates a significant socioeconomic burden due to its negative impact on quality of life, tremendous medical expense, and possible cancer risk. Although treatment modalities are similar between LPR and GERD, the diagnosis of LPR is more challenging than GERD due to its non-specific symptoms/signs. Due to the lack of pathognomonic features of endoscopy, mounting evidence focused on physiological diagnostic testing. Two decades ago, a dual pH probe was considered the gold standard for detecting pharyngeal acidic reflux episodes. Despite an association with LPR, the dual pH was unable to predict the treatment response in clinical practice, presumably due to frequently encountered artifacts. Currently, hypopharygneal multichannel intraluminal impedance-pH catheters incorporating two trans-upper esophageal sphincter impedance sensors enable to differentiate pharyngeal refluxes from swallows. The validation of pharyngeal acid reflux episodes that are relevant to anti-reflux treatment is, therefore, crucial. Given no diagnostic gold standard of LPR, this review article aimed to discuss the evolution of objective diagnostic testing and its predictive role of treatment response.

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Distinct Physiological Characteristics of Isolated Laryngopharyngeal Reflux Symptoms

Lien

Wang

Kao

et al. 2020

Clinical Gastroenterology and Hepatology

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The suitability of the GERDyzer instrument in pH-test-proven laryngopharyngeal reflux patients

Abstract: Supplemental Digital Content is available in the text

Cited by 3 publications

References 39 publications

Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease

Laryngopharyngeal reflux disease: Updated examination of mechanisms, pathophysiology, treatment, and association with gastroesophageal reflux disease

Diagnosis of Laryngopharyngeal Reflux: Past, Present, and Future—A Mini-Review

Distinct Physiological Characteristics of Isolated Laryngopharyngeal Reflux Symptoms

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