The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

Park, Yong; Kim, Dae Sik; Park, Seh Jong; Seo, Hyungjoon; Lee, Se Ryeon; Sung, Hwa Jung; Park, Kyong Hwa; Choi, In Keun; Kim, Seok Jin; Oh, Sang Cheul; Seo, Jae Hong; Choi, Chul Won; Kim, Byung Soo; Shin, Sang Won; Kim, Yeul Hong; Kim, Jun Suk

doi:10.1016/j.leukres.2009.08.024

Cited by 19 publications

(27 citation statements)

References 42 publications

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“…Wichtig ist ein früher Beginn der Behandlung bereits vor Entwicklung einer Transfusionsabhängigkeit, die wiederum die Notwendigkeit einer Eisenchelationstherapie nach sich ziehen würde. Der Beginn einer Transfusionstherapie lässt sich dadurch zeitlich erheblich hinauszögern [19,20].…”

Section: Esas Und Alternativenunclassified

Reports of Oncological Societies

2016

Oncol Res Treat

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Section: Esas Und Alternativenunclassified

Reports of Oncological Societies

2016

Oncol Res Treat

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“…The infections caused by these bacterial pathogens are endemic now in many countries and cause a wide range of morbidity and mortality (6, 8–13). Routine detection of bacterial pathogens in clinical laboratories is based on enrichment culture, microscopic observation and biochemical assay (14–17). Although culture testing is the gold standard for the assessment of infectious diseases, the whole procedure has several limitations, such as being time-consuming, laborious, and the difficulty of quantitative analysis.…”

Section: Introductionmentioning

confidence: 99%

Detection of eight foodborne bacterial pathogens by oligonucleotide array hybridization

et al. 2017

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BackgroundSimultaneous and rapid detection of multiple foodborne bacterial pathogens is important for the prevention of foodborne illnesses.ObjectiveThe aim of this study was to evaluate the use of 16S rDNA and 23S rDNA sequences as targets for simultaneous detection of eight foodborne bacterial pathogens.MethodsNineteen bacterial oligonucleotide probes were synthesized and applied to nylon membranes. Digoxygenin labeled 16S rDNA and 23S rDNA from bacteria were amplified by PCR using universal primers, and the amplicons were hybridized to the membrane array. Hybridization signals were visualized by NBT/BCIP color development.ResultsThe eight intestinal bacterial pathogens including Salmonella enterica, Escherichia coli, Bacillus cereus, Vibrio cholerae, Shigella dysenteriae, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis were appropriately detected in a panel of oligonucleotide array hybridization. The experimental results showed that the method could discriminate the bacterial pathogens successfully. The sensitivity of oligonucleotide array was 103 CFU/ml.ConclusionThis study showed that 16S rDNA and 23S rDNA genes had sufficient sequence diversity for species identification and were useful for monitoring the populations of foodborne pathogenic bacteria. Furthermore, results obtained in this study revealed that oligonucleotide array hybridization had a powerful capability to detect and identify the bacterial pathogens simultaneously.

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“…In addition, many other risk factors (such as age, the chemotherapy protocol, prophylactic antifungal treatment, gastrointestinal system sterilization, the neutrophil count during the attack, and thrombocytopenia) were identified as risk factors in many studies (1)(2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Hematolojik malignite nedeniyle kemoterapi verilen hastalarda febril nötropenik atak gelişimi için risk faktörleri

Soyer¹,

Yilmaz²,

Aydemir³

et al. 2015

Ege Tıp Dergisi

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Aim Febrile neutropenic attacks are an important problem during and after chemotherapy. We retrospectively reviewed the records of patients who were administered chemotherapy treatment to identify the risk factors for febrile neutropenic attacks. Materials and Methods Conclusion:Acute leukemia, stem cell transplantation, length of the neutropenic period ≥ 10 days and treatment with G-CSF were the most important risk factors for febrile neutropenic attacks. The result that G-CSF was a risk factor for febrile neutropenia was attributed to the fever-inducing effect of this drug. The use of G-CSF should be questioned in neutropenic patients with fever, especially in those without signs and symptoms of infection. yaş, cinsiyet, kemoterapi rejimi, kök hücre transplantasyonu, nötropeni süresi, arasındaki ilişki logistic regresyon modeli kullanılarak analiz edildi. Keywords Bulgular:Febril nötropenik atak 201(% 77) yatış periyodunda saptandı. Akut lösemi tanısı (OR: 3.36, % 95 CI, p: 0.02), kök hücre nakli (OR:8.77, %95 CI, p:0.001), 95% CI, p: 0.000) ve nötropenik periyodun ≥ 10 gün olması (OR: 4.01, % 95 CI, p: 0.001) febril nötropenik atak için risk faktörü olarak saptandı.

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The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

Cited by 19 publications

References 42 publications

Reports of Oncological Societies

Reports of Oncological Societies

Detection of eight foodborne bacterial pathogens by oligonucleotide array hybridization

Hematolojik malignite nedeniyle kemoterapi verilen hastalarda febril nötropenik atak gelişimi için risk faktörleri

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