The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network

Sakr, Soulaïman; Wang, Ming; Dédaldéchamp, Fabienne; Pérez-Garcia, Maria-Dolores; Ogé, Laurent; Hamama, Latifa; Atanassova, Rossitza

doi:10.3390/ijms19092506

Cited by 179 publications

(139 citation statements)

References 469 publications

(493 reference statements)

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“…6) and the small growth phenotypes of the pp7l mutant ( Fig. 1) would be in accordance with sugar-signaling regulators playing a central role in the regulation of starch metabolism (Sakr et al, 2018;Wurzinger et al, 2018). With its predicted function as an inactive Ser/Thr phosphatase, it is unlikely that it is a transcription factor and future studies will have to clarify the molecular function of PP7L.…”

Section: Pp7l Contributes To the Tolerance To Abiotic Stressessupporting

confidence: 56%

Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance

Marino

Klingl

et al. 2019

Plant Physiol.

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Chloroplast biogenesis is indispensable for proper plant development and environmental acclimation. In a screen for mutants affected in photosynthesis, we identified the protein phosphatase7-like (pp7l) mutant, which displayed delayed chloroplast development in cotyledons and young leaves. PP7L, PP7, and PP7-long constitute a subfamily of phosphoprotein phosphatases. PP7 is thought to transduce a blue-light signal perceived by crys and phy a that induces expression of SIGMA FACTOR5 (SIG5). We observed that, like PP7, PP7L was predominantly localized to the nucleus in Arabidopsis (Arabidopsis thaliana), and the pp7l phenotype was similar to that of the sig6 mutant. However, SIG6 expression was unaltered in pp7l mutants. Instead, loss of PP7L compromised translation and ribosomal RNA (rRNA) maturation in chloroplasts, pointing to a distinct mechanism influencing chloroplast development. Promoters of genes deregulated in pp7l-1 were enriched in PHYTOCHROME-INTERACTING FACTOR (PIF)-binding motifs and the transcriptome of pp7l-1 resembled those of pif and CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1) signalosome complex (csn) mutants. However, pif and csn mutants, as well as cop1, cryptochromes (cry)1 cry2, and phytochromes (phy)A phyB mutants, do not share the pp7l photosynthesis phenotype. PhyB protein levels were elevated in pp7l mutants, but phyB overexpression plants did not resemble pp7l. These results indicate that PP7L operates through a different pathway and that the control of greening and photosystem biogenesis can be separated. The lack of PP7L increased susceptibility to salt and high-light stress, whereas PP7L overexpression conferred resistance to highlight stress. Strikingly, PP7L was specifically recruited to Brassicales for the regulation of chloroplast development. This study adds another player involved in chloroplast biogenesis.

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Section: Pp7l Contributes To the Tolerance To Abiotic Stressessupporting

confidence: 56%

Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance

Marino

Klingl

et al. 2019

Plant Physiol.

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“…As mentioned above, high sugar levels may explain a reduction of apical dominance in response to environmental or genetic factors increasing the source/sink balance within the plant. Sugars act through different signaling pathways, including those related to sucrose-, hexokinase-, glycolysis (Li & Sheen, 2016; Sakr et al , 2018; Wingler, 2018). It has been suggested that sucrose could promote bud outgrowth in a signaling manner in rose and pea (Barbier et al , 2015b; Fichtner et al , 2017) and further experiments are required to determine the molecular mechanisms underlying the interactions between sugar availability and auxin.…”

Section: Discussionmentioning

confidence: 99%

Sugar availability suppresses the auxin-induced strigolactone pathway to promote bud outgrowth

Bertheloot

Barbier

Boudon

et al. 2019

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+33 (0)2 41 22 56 32 2 SUMMARY• Apical dominance occurs when the growing shoot tip inhibits the outgrowth of axillary buds. Apically-derived auxin in the nodal stem indirectly inhibits bud outgrowth via cytokinins and strigolactones. Recently, sugar deprivation was found to contribute to this phenomenon.• Using rose and pea, we investigated whether sugar availability interacts with auxin in bud outgrowth control, and the role of cytokinins and strigolactones, in vitro and in planta.• We show that sucrose antagonizes auxin's effect on bud outgrowth, in a dosedependent and coupled manner. Sucrose also suppresses strigolactone-inhibition of outgrowth, and rms3 strigolactone-perception mutant is less affected by reducing sucrose supply; however, sucrose does not interfere with the regulation of cytokinin levels by auxin, and stimulates outgrowth even with optimal cytokinin supply. These observations were assembled into a computational model where sucrose represses bud response to strigolactones, largely independently of cytokinin levels. It quantitatively captures our observed dose-dependent sucrose-hormones effects on bud outgrowth, and allows us to express outgrowth response to various combinations of auxin and sucrose levels as a simple quantitative law.• This study places sugars in the bud outgrowth regulatory network, and paves the way for better understanding of branching plasticity in response to environmental and genotypic factors.Versailles, France) for providing the seeds of Pisum sativum and GR24. We thank the Environment and Agronomy department of INRA for financial support.

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“…Suc, hexoses, and trehalose also function as signal molecules that participate in control of nutrient homeostasis, stress response, and organ development (Paul et al, 2008;Lastdrager et al, 2014). In addition, hexokinase 1 (HXK1) and Suc non-fermenting-1-related protein kinase (SnRK1) were reported to be related to sugar signaling, as two dependent pathways (Moore et al, 2003;Broeckx et al, 2016;Sakr et al, 2018). Although the relationship between trehalose-6-phosphate and Suc signaling in plant remains to be fully resolved, it is known that trehalose-phosphate synthase (TPS) plays an important role in controlling the ratio of trehalose-6-phosphate and Suc (Figueroa and Lunn, 2016;Sakr et al, 2018).…”

mentioning

confidence: 99%

Down-regulation of the Sucrose Transporter CsSUT1 Causes Male Sterility by Altering Carbohydrate Supply

et al. 2019

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ORCID ID: 0000-0002-9247-7185 (Z.Z.).In plants, male sterility is an important agronomic trait, especially in hybrid crop production. Many factors are known to affect crop male sterility, but it remains unclear whether Suc transporters (SUTs) participate directly in this process. Here, we identified and functionally characterized the cucumber (Cucumis sativus) CsSUT1, a typical plasma membrane-localized energy-dependent high-affinity Suc-H + symporter. CsSUT1 is expressed in male flowers and encodes a protein that is localized primarily in the tapetum, pollen, and companion cells of the phloem of sepals, petals, filaments, and pedicel. The male flowers of CsSUT1-RNA interference (RNAi) lines exhibited a decrease in Suc, hexose, and starch content, relative to those of the wild type, during the later stages of male flower development, a finding that was highly associated with male sterility. Transcriptomic analysis revealed that numerous genes associated with sugar metabolism, transport, and signaling, as well as with auxin signaling, were down-regulated, whereas most myeloblastosis (MYB) transcription factor genes were up-regulated in these CsSUT1-RNAi lines relative to wild type. Our findings demonstrate that male sterility can be induced by RNAi-mediated down-regulation of CsSUT1 expression, through the resultant perturbation in carbohydrate delivery and subsequent alteration in sugar and hormone signaling and up-regulation of specific MYB transcription factors. This knowledge provides a new approach for bioengineering male sterility in crop plants.

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The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network

Cited by 179 publications

References 469 publications

Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance

Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance

Sugar availability suppresses the auxin-induced strigolactone pathway to promote bud outgrowth

Down-regulation of the Sucrose Transporter CsSUT1 Causes Male Sterility by Altering Carbohydrate Supply

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