The Success of A.I.D. and Semen Characteristics: Study on 1489 Cycles and 192 Ejaculates

The results obtained by insemination with 3,418 frozen donor ejaculates with known semen characteristics were analyzed. The concentrations of motile spermatozoa before and after thawing were significantly higher in samples from donors producing pregnancies compared to samples from donors not causing pregnancies. In ejaculates known specifically to have caused a pregnancy even higher concentrations were found. It was assumed that the concentration of motile spermatozoa after thawing was the most important parameter, and by dividing the material into fractions it could be demonstrated that a spermatozoa concentration of more than 20 million/ml is essential for reasonable results.

Section: Discussionsupporting

confidence: 75%

mentioning

confidence: 99%

Obtained Pregnancies by AID Using Frozen Semen in Relation to Specific Qualities of the Semen

Nielsen¹,

Risum²,

Hansen³

et al. 1984

“…Several publications on AID have reported that despite selection of donors on the basis of superior semen quality, pregnancy rates vary widely among donors [10][11][12]. In the present study, the association between suboptimal semen quality and donor fecundability was studied in 128 female recipients un- dergoing AID cycles.…”

Section: Discussionmentioning

confidence: 99%

Fertility Potential of Individual Sperm Donors

Al-Inany

Dunselman²,

Dumoulin³

et al. 1999

Objective: To study the fertility potential of individual semen donors with ejaculates of optimal as compared to suboptimal quality. Methods: 363 semen donations were obtained from 11 donors between January 1993 and September 1997. 270 samples were cryopreserved and 1,399 straws obtained from 120 ejaculates were used in 495 insemination cycles. Results: 52 pregnancies were achieved in 128 recipients (40.6%). No significant differences were found between donors of high fecundability and those of low fecundability regarding sperm parameters. The mean donor fecundability index was 10.5%. The optimal and suboptimal samples yielded similar results. Donors with suboptimal semen quality had an increased number of samples rejected after thawing. Conclusion: Traditional semen analysis parameters do not differentiate high from low fecundability donors. Suboptimal results of the semen analysis should not exclude potential donors from an artificial insemination donor (AID) program.

“…Trounson et al [1980] obtained pregnancies using semen with 18.3 ± 9.41 • 106 MST, and David et al [1980] established a limit of 12.5-106 MST, using semen from donors of known fertility. In our material the lowest concentration was 15-106 MST.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Quality Variations of Ejaculates from Individual Donors for Establishing a Quality Control Scheme

Risum¹,

Nissen²,

Hansen³

et al. 1984

Semen for use in artificial insemination must be of good quality. To satisfy this demand we have to be able to predict the quality of semen from individual donors. Statistical analyses of data on 3,418 ejaculates from 87 donors demonstrated that each donor’s ejaculates could be characterized by a lognormal distribution of the sperm concentration, the concentration of motile spermatozoa before freezing and the concentration of motile spermatozoa after thawing. Furthermore, the ratio of the concentration of motile spermatozoa before freezing to the total sperm concentration and the fraction of motile spermatozoa surviving the freezing procedure were found to be constant for individual donors. Based on these observations a statistical quality control scheme for the selection of donors and for the continuous control of semen quality is presented.