The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study

Chen, Xiao; Chen, Ning-Xuan; Shen, Yangqian; Li, Huixian; Li, Le; Lu, Bin; Zhu, Zhili; Fan, Zhen; Chen, Yan

doi:10.1016/j.neuroimage.2020.117185

Cited by 60 publications

(52 citation statements)

References 93 publications

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“…The individual's tendency to daydream is positively associated with dynamic functional connectivity between PCC and the MTL subsystem (Kucyi & Davis, 2014). A study on rumination (Chen et al, 2020) also found an increased connectivity between Core and MTL and a decreased coupling between Core and dMPFC when subjects were in a state of rumination, compared to that in a distraction state. Based on these studies, it is reasonable to conjecture that such a decreased coupling between Core and MTL during short video viewing is related to less occurrence of spontaneous thoughts due to enhanced engagement in processing external video stimuli.…”

Section: Discussionmentioning

confidence: 92%

Individualized video recommendation modulates functional connectivity between large scale networks

Zhou

Wang

et al. 2021

Human Brain Mapping

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With the emergence of AI‐powered recommender systems and their extensive use in the video streaming service, questions and concerns also arise. Why can recommended video content continuously capture users' attention? What is the impact of long‐term exposure to personalized video content on one's behaviors and brain functions? To address these questions, we designed an fMRI experiment presenting participants with personally recommended videos and generally recommended ones. To examine how large‐scale networks were modulated by personalized video content, graph theory analysis was applied to investigate the interaction between seven networks, including the ventral and dorsal attention networks (VAN, DAN), frontal–parietal network (FPN), salience network (SN), and three subnetworks of default mode network (dorsal medial prefrontal (dMPFC), Core, and medial temporal lobe (MTL)). Our results showed that viewing nonpersonalized video content mainly enhanced the connectivity in the DAN‐FPN‐Core pathway, whereas viewing personalized ones increased not only the connectivity in this pathway but also the DAN‐VAN‐dMPFC pathway. In addition, both personalized and nonpersonalized short videos decreased the couplings between SN and VAN as well as between two DMN subsystems, Core and MTL. Collectively, these findings uncovered distinct patterns of network interactions in response to short videos and provided insights into potential neural mechanisms by which human behaviors are biased by personally recommended content.

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Section: Discussionmentioning

confidence: 92%

Individualized video recommendation modulates functional connectivity between large scale networks

Zhou

Wang

et al. 2021

Human Brain Mapping

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“…Scientific understanding of the default network has evolved considerably in the last two decades. It is no longer thought of as a "task-negative network", but is instead understood to support a variety of internal mental processes [5,20], including mindwandering [14], autobiographical planning [11,113], creative thinking [16,18,[183][184][185], dreaming [186], and rumination [187][188][189], as well as aspects of self-experience [23,24]. Indeed, default network activation is task-positive when the experimental task requires internal-oriented mental processes, including when these processes are goal-directed [11].…”

Section: Automatic Constraintsmentioning

confidence: 99%

Prefrontal contributions to the stability and variability of thought and conscious experience

Zamani

Carhart‐Harris

Christoff

2021

Neuropsychopharmacol.

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The human prefrontal cortex is a structurally and functionally heterogenous brain region, including multiple subregions that have been linked to different large-scale brain networks. It contributes to a broad range of mental phenomena, from goal-directed thought and executive functions to mind-wandering and psychedelic experience. Here we review what is known about the functions of different prefrontal subregions and their affiliations with large-scale brain networks to examine how they may differentially contribute to the diversity of mental phenomena associated with prefrontal function. An important dimension that distinguishes across different kinds of conscious experience is the stability or variability of mental states across time. This dimension is a central feature of two recently introduced theoretical frameworks—the dynamic framework of thought (DFT) and the relaxed beliefs under psychedelics (REBUS) model—that treat neurocognitive dynamics as central to understanding and distinguishing between different mental phenomena. Here, we bring these two frameworks together to provide a synthesis of how prefrontal subregions may differentially contribute to the stability and variability of thought and conscious experience. We close by considering future directions for this work.

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“…When the brain was confronted with different cognitive demands, the FPN can preferentially couple with DMN, as well as the FPN and DMN coordinate the reconstruction of the entire network recon gurations by played different roles [15,34]. In this study, we used the participation coe cient based on the sub-networks partition of Yan et al [9]. As the hub of DMN, core subsystem regulates high-order cognitive function depending on top-down [8].…”

Section: Discussionmentioning

confidence: 99%

“…The MTL subsystem includes the ventral medial prefrontal cortex (vMPFC), posterior inferior parietal lobule, retrosplenial cortex, parahippocampal cortex and hippocampal formation, which is associated with memory processes, such as episodic memory retrieval [7]. Importantly, converging evidences have revealed that the core subsystem is proposed to be the hub linking the other two subsystems together, as well as the functional connectivity of the core subsystem is dependent of the disease which including the anterior medial prefrontal cortex (amPFC) and the posterior cingulate cortex (PCC) [6,[8][9][10]. Furthermore, our previous study has demonstrated that the core subsystem-centered connection abnormalities were associated with the progress of cognitive impairments in AD-spectrum patients [8].…”

Section: Introductionmentioning

confidence: 99%

Plasma NFL Disrupt Cognitive Integrity Via Coupling the Interactions of Core Subsystem and Frontoparietal Network in Alzheimer's Disease

Yao

Zhang

Zhao

et al. 2021

Preprint

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Backgroud: Plasma neurofilament light chain (NFL) is a potential biomarker for neurodegenerative diseases. Both NFL and the interactions of core subsystem and frontoparietal network (FPN) are associated with the cognitive integrity. The present study was to investigate the underlying mechanism and application of plasmaNFL couplingcore-FPN in Alzheimer’s disease (AD). Methods: A total of 224 AD-spectrum participants with complete resting-state fMRI, neuropsychological tests and plasma NFL at baseline (n=112) and after approximately 17 months follow up (n=112) . Brain networks construction of core subsystem and FPN wereperformed in these subjects. The follow-up data were used to test and verify these baseline characteristics. Furthermore, Receiver Operating Characteristic analysiswas used to explore the classification by the association of plasma NFL and core-FPN, and the mediation analysis were appliedto investigate the significance of plasma NFL coupling networks on cognitive impairments in these subjects. Results: The discernment ofdisease-relatedinteractions of core subsystem and FPN maybe the neural network fundamentals of plasmaNFL regarding to cognitive decline in AD-spectrum patients. Furthermore, the clinical significance of plasma NFL coupling networks on AD identification and monitoring cognitive impairments were observed in these subjects. Conclusions: The characteristic change of plasma NFL coupling networks could expect to be used as an potential indicator of future targeted therapies and prevention strategies in AD patients.

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The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study

Cited by 60 publications

References 93 publications

Individualized video recommendation modulates functional connectivity between large scale networks

Individualized video recommendation modulates functional connectivity between large scale networks

Prefrontal contributions to the stability and variability of thought and conscious experience

Plasma NFL Disrupt Cognitive Integrity Via Coupling the Interactions of Core Subsystem and Frontoparietal Network in Alzheimer's Disease

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