The subretinal fluid in retinal detachment

Abstract

Following retinal detachment, subretinal fluid (SRF) fills the neoformed space. Subsequently subretinal and preretinal strands of proliferative tissue begin to form. We have collected the subretinal fluid withdrawn during retinal detachment surgery. We have studied subretinal fluid cytologically to evaluate the number and the type of cells present in the fluid, and by means of transmission electron microscopy. The first cell type to be present in the fluid represented degenerated aspects of pigmented epithelial cells (PECs). Successively, other cell types appeared in the fluid as nerve cells (rods, cones and glial cells), macrophages and well preserved pigmented epithelial cells.

Multifactor analysis of delayed absorption of subretinal fluid after scleral buckling surgery

“…This is consistent with Veckeneer's view that the inferior RD is more prone to postoperative PSF, and that the duration is longer [15,20,21]. Prolonged retentions of vitreous diffusion into the subretinal fluid may lead to the remodification of protein components and macromolecules [22,23], resulting in decreased absorption of SRF by RPE. When the retina is detached for a significant Fig.…”

Nature of subretinal fluid in patients undergoing vitrectomy for macular hole: a cytopathological and optical coherence tomography study

“…Macrophages are not normally found in significant numbers in healthy retina. When the retina however becomes separated from the RPE as in retinal detachment, clumps of macrophages can be seen in the subretinal space 22 and on the surface of the RPE. These may be derived either from RPE cells or recruited from the choroid.…”

Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review

“…3) (Heidelberg Spectralis, Heidelberg Engineering, Germany). Biochemical and histological analyses have furthermore shown that large molecules such as proteins and GAG, as well as cells and cellular debris, are concentrated in longstanding SRF [35,36]. These compounds cannot be removed through ion or water channels, resulting in an imbalance between the decreased capability of and the increased need for phagocytosis by RPE cells.…”