The subplacenta of the red-rumped agouti (Dasyprocta leporina L)

Rodrigues, Rosangela; Carter, Anthony Michael; Ambrósio, Carlos Eduardo; Santos, T. C.; Miglino, María Angélica

doi:10.1186/1477-7827-4-31

Cited by 33 publications

(11 citation statements)

References 29 publications

(38 reference statements)

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“…Our findings in the prea were in accordance to former studies that the subplacenta was active and proliferative in early and mid-gestation (Davies et al 1961a, 1961b, Kaufmann & Davidoff 1977, Wolfer & Kaufmann 1980, Kaufmann 2004, Miglino et al 2002, 2004, Bonatelli et al 2005, Oliveira et al 2006, Rodrigues et al 2006, Bosco et al 2007, Mess 2003, 2007a, 2007b, Mess & Carter 2007, 2012a, 2012b, Kanashiro et al 2009, Flamini et al 2011. Immunostaining for the proliferation marker PCNA and revealing the mitotic index by morphology both resulted in high proliferation early on, followed by an abrupt decrease around day 45 and further decrease towards term.…”

Section: Discussionsupporting

confidence: 92%

“…The here investigated near term stages indicated that Galea belonged to the second group. The positive PAS reaction of the syncytiotrophoblast and the material inside its lacunae, indicating active glycolysation processes associated with secretion, supported a former hypothesis (Rodrigues et al 2006) that the release of hormones, growth factors or other substances to the fetal unit may be of special importance and may also be involved in processes of forthcoming birth. Thus, Galea and other species represented a more basal pattern of caviomorphs than the guinea pig itself, which is also observed in embryos as concluded by Franciolli et al (2011) studying South American histricomorphic embryos and this variations need to be considered for comparative studies with human placentation as concluded by Miglino et al (2008).…”

Section: Discussionsupporting

confidence: 68%

“…For the first time, proliferation processes inside the subplacenta were revealed by three independent methods, supporting the former results. During advanced gestation, the subplacenta generally degenerated (Davies et al 1961a, 1961b, Kaufmann & Davidoff 1977, Wolfer & Kaufmann 1980, Miglino et al 2002, 2004, Mess 2003, 2007a, 2007b, Kaufmann 2004, Bonatelli et al 2005, Oliveira et al 2006, 2012a, 2012b, Rodrigues et al 2006, Bosco et al 2007, Mess & Carter 2007, Kanashiro et al 2009, Flamini et al 2011. In addition, these results corroborate with those described in the capybara (Kanashiro et al 2009) and in the punaré (Oliveira et al 2012a), however the final phases are not approached in this regard.…”

Section: Discussionsupporting

confidence: 59%

“…However, a functional state was maintained much longer than in the guinea pig, where the organ was fully resorbed near term (Davies et al 1961a, 1961b, Kaufmann & Davidoff 1977, Kaufmann 2004, Mess 2007a, Flamini et al 2011, Carter & Mess 2014. In contrast, the subplacenta was reduced and filled with amorphous material, but still present and supplied by fetal vessels in the degu, punare, paca, agouti, capybara, and the rock cavy Kerodon rupestris (Miglino et al 2002, 2004, Bonatelli et al 2005, Oliveira et al 2006, 2012a, 2012b, Rodrigues et al 2006, Mess 2007a, Kanashiro et al 2009. The here investigated near term stages indicated that Galea belonged to the second group.…”

Section: Discussionmentioning

confidence: 72%

“…In the last decade placentation was investigated in several caviomorph species (Davies et al 1961a, 1961b, Kaufmann & Davidoff 1977, Wolfer & Kaufmann 1980, Miglino et al 2002, 2004, Kaufmann 2004, Bonatelli et al 2005, Oliveira et al 2006, Rodrigues et al 2006, Bosco et al 2007, Mess 2003, 2007a, 2007b, Mess & Carter 2007, Kanashiro et al 2009, Flamini et al 2011, Oliveira et al 2012a, 2012b) revealing a quite stable pattern of evolution that is largely independent from size diameters or reproductive specializations (Kanashiro et al 2009, Flamini et al 2011, Mess 2011, 2014. In particular, trophoblast invasion in caviomorphs is associated with a specialized area within the placental disk, the so-called subplacenta (Kaufmann 2004, Rodrigues et al 2006, Mess 2007a, 2014. It represents an area of folded layers of cellular and syncytial trophoblast, formed at the central excavation in association to the maternal blood system early in gestation, but that is supplied by fetal vessels only in later phases (Fig.1).…”

Section: Introductionmentioning

confidence: 99%

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Subplacental development in Galea spixii

et al. 2018

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Animal models are essential to understand healthy human placentation. Guinea pig related rodents became on focus for such purposes. In particular, processes of trophoblast invasion are similar. The latter is associated with a specialized area, the subplacenta. Since previous results showed differences between the guinea pig and its close relative Galea spixii, we aimed to study subplacental development with more detail. We investigated 16 pregnant females of 14 to 55 days of gestation by means of histology, morphometrics, immunohistochemistry and electron microscopy. The overlap between the fetomaternal blood systems resulted as intimate, suggesting some exchange processes. Proliferation was revealed by three independent methods, being most active in early and mid-gestation, which was in accordance to former results. Though degeneration of tissues took place, the subplacenta was maintained towards term with access to the fetal vascularization, supporting a hypothesis about the release of substances to the fetal unit in advanced gestation. In contrast to other species, the extraplacental trophoblast showed a shift from syncytial streamers to giant cells during mid-gestation. Views on placentation in caviomorphs were influenced by the guinea pig, but our data supported recent studies that the subplacenta had a much greater placidity. In regard to subplacental grow, degeneration and likely also exchange processes, Galea and other species showed a more basal pattern of caviomorphs than the guinea pig. Such differences should be considered, when choosing most adequate animal models for special purposes in comparison to human placentation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 68%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Subplacental development in Galea spixii

et al. 2018

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The subplacenta in Octodon degus and petromus typicus—two hystricognath rodents without significant placental lobulation

Mess

2006

J Exp Zool Pt B

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Until now, defining characters of hystricognath rodents have been the subplacenta and the lobulation of the main chorioallantoic placenta. However, recent studies have revealed hystricognaths without marked lobulation, which is a plesiomorphic condition of the group. The question thus arises whether the subplacenta of these taxa is structurally homologous to that of other hystricognaths. Therefore, subplacental morphology and ontogeny were investigated in Octodon and Petromus by conventional light and electron microscopy, and the stem species pattern of Hystricognathi was reconstructed by applying MacClade. The subplacentae of both species share important similarities with other hystricognaths. The organ develops early in gestation but degenerates towards term. It consists of folded layers of cellular and syncytial trophoblast, the latter enclosing maternal blood lacunae and electron-dense particles. Root-like syncytial outgrowths (syncytial streamers) and extraplacental trophoblast cells occur at the lateral and basal borders of the organ. Maternal vascularisation by blood lacunae within the subplacental syncytiotrophoblast is acquired early but lost during mid-gestation. Vascularisation by fetal vessels is established later. Fetomaternal exchange via blood circulation inside the subplacenta is unlikely to occur, since periods of maternal and fetal vascularisation show little overlap. In conclusion, the subplacentae of both species are regarded as homologous to other hystricognaths, comprising 18 character conditions that belong to their stem species pattern. Thus, the systematic unity of the group can be confirmed.

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Immunohistochemical identification of the extravillous trophoblast during the placentation of the degu (Octodon degus)

Bosco

Buffet

2008

J Exp Zool Pt B

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Recent data indicate that placentation in Octodon degus is similar to that in humans, making it a potential animal model for studies in human placental pathologies related to alterations in the migration of the extravillous trophoblast (EVT). Our objective was to immunohistochemically identify degu EVT during placentation by using cytoskeletal protein markers to establish the normal migratory pattern of the EVT. Fifteen O.degus were divided into three equal groups: day 27, 60, and 84 of gestation. The placentas were immunostained for cytokeratin (CK) and alpha smooth muscle actin (SMA). At day 27, the migrating EVT immunostained for SMA but not for CK. Once the EVT was incorporated in the maternal vessels (day 60) it was positive for CK but negative for SMA. The smooth muscle cells of the mesometrial arteries that remained after EVT invasion were positive for SMA. At day 84, the media muscular layer had partially regenerated but some EVT was still present. Furthermore, at day 27 cyclooxygenase-1 (COX-1) was detected in the endothelium of the maternal decidual vessels. Our results suggest that during the early stages of placentation, the cytoskeletal organization of the actin network of the migrating EVT corresponds to that of a cell with motile behavior. Once the EVT invaded the spiral arteries, the cytoskeleton reorganized, adopting the structure of an epithelial-like cell, expressing CK intermediate filaments. The media muscle layer regenerated near the end of gestation but some EVT remained. During EVT formation the endothelium of the maternal decidual vessels immunostained for COX-1.

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The subplacenta of the red-rumped agouti (Dasyprocta leporina L)

Cited by 33 publications

References 29 publications

Subplacental development in Galea spixii

Subplacental development in Galea spixii

The subplacenta in Octodon degus and petromus typicus—two hystricognath rodents without significant placental lobulation

Immunohistochemical identification of the extravillous trophoblast during the placentation of the degu (Octodon degus)

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