The subcortical connectome: Hubs, spokes and the space between – a vision for further research in neurodegenerative disease

Looi, Jeffrey Cl; Walterfang, Mark; Power, Brian; Westen, Danielle van; Velakoulis, Dennis; Wahlund, Lars‐Olof; Thompson, Paul M.

doi:10.1177/0004867413506753

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…Through the Australian hub, we are connecting with and through to our US and Swedish collaborators. Much of our work has focused upon mapping a subcortical connectome 14 with the key subcortical brain structures as potential biomarkers for neurodegenerative disease. This network has resulted in approximately 20 publications in the last 5 years, largely through the goodwill of the clinical and neuroscience researchers involved.…”

Section: Table 1 Establishing a New Collaborative Networkmentioning

confidence: 99%

The Australian, US, Scandinavian Imaging Exchange (AUSSIE): an innovative, virtually-integrated health research network embedded in health care

Looi

Velakoulis

Walterfang

et al. 2014

Australas Psychiatry

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Objective To describe the development, design and function of an innovative international clinical research network for neuroimaging research based in Australia within a joint state health service/medical school. This network focuses upon identifying neuroimaging biomarkers for neuropsychiatric and neurodegenerative disease. Method We describe a case study of the iterative development of the network, identifying characteristic features and methods which may serve as potential models for virtual clinical research networks. This network was established to analyse clinically–derived neuroimaging data relevant to neuropsychiatric and neurodegenerative disease, specifically in relation to subcortical brain structures. Results The network has harnessed synergies from the individual expertise of the component groups, primarily clinical neuroscience researchers, to analyse a variety of clinical data. Conclusion AUSSIE is an active virtual clinical research network, analogous to a connectome, which is embedded in health care and has produced significant research advancing our understanding of neuropsychiatric and neurodegenerative disease through the lens of neuroimaging.

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Section: Table 1 Establishing a New Collaborative Networkmentioning

confidence: 99%

The Australian, US, Scandinavian Imaging Exchange (AUSSIE): an innovative, virtually-integrated health research network embedded in health care

Looi

Velakoulis

Walterfang

et al. 2014

Australas Psychiatry

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“…Investigating neuronal elements can be done by quantifying disease-related effects on the morphology of 'hubs' (Looi et al, 2014) while interconnections can be investigated via resting-state functional connectivity (FC) analyses (Damoiseaux et al, 2006). Due to the importance of the caudate nucleus, putamen and the thalamus to the abnormal neural activity associated with PD, coupled with the fact that these structures are considered important hubs in brain networks (Hwang et al, 2017, Looi andWalterfang, 2013), an analysis of the morphology and FC of these structures may yield neuroimaging biomarkers of brain network abnormalities in PD that relate to cognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease

Owens‐Walton

Jakabek

Power

et al. 2021

Psychiatry Research: Neuroimaging

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“…To understand the functioning of brain networks it is necessary to study both the constituent neuronal elements of networks, as well as their interconnections (Sporns et al, 2005). Investigating neuronal elements can be done by quantifying disease-related effects on the morphology of ‘hubs’ (Looi et al, 2014) while interconnections can be investigated via resting-state functional connectivity (FC) analyses (Damoiseaux et al, 2006). Due to the importance of the caudate nucleus, putamen and the thalamus to the abnormal neural activity associated with PD, coupled with the fact that these structures are considered important hubs in brain networks (Hwang et al, 2017, Looi and Walterfang, 2013), an analysis of the morphology and FC of these structures may yield neuroimaging biomarkers of brain network abnormalities in PD that relate to cognitive dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging biomarkers differentiate Parkinson disease with and without cognitive impairment and dementia

Owens‐Walton

Jakabek

Power

et al. 2019

Preprint

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Objective: Cognitive impairment in Parkinson disease (PD) places a high burden on patients and the pathophysiological mechanisms that differentiate patients with cognitive impairment from those without it are still incompletely understood. Methods: We conducted a resting-state seed region-of-interest approach to investigate functional connectivity (FC) of important subdivisions of the caudate nucleus, putamen and thalamus in controls (n=33), cognitively unimpaired subjects (PD-CU, n=33), PD subjects with mild cognitive impairment (PD-MCI, n=22) and subjects with dementia (PDD, n=17). We then investigated how the morphology of these structures differed between groups. Results: PD-CU subjects, compared to controls, displayed increased and decreased FC of caudate, putamen and thalamic subdivisions. PD-MCI subjects demonstrated reduced FC of the mediodorsal thalamus with the paracingulate cortex, compared to PD-CU, and reduced FC of the mediodorsal thalamus with the posterior cingulate cortex compared to PDD. Extensive volumetric and surface-based deflation was found in subjects with dementia. Conclusions: Our research suggests that cognitive impairment and dementia in PD may be associated with a breakdown in FC of the mediodorsal thalamus with para- and posterior cingulate regions of the brain, respectively. Significance: Cognitive impairment and dementia in PD may relate to pathophysiological changes in FC of the mediodorsal thalamus.

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The subcortical connectome: Hubs, spokes and the space between – a vision for further research in neurodegenerative disease

Cited by 16 publications

References 19 publications

The Australian, US, Scandinavian Imaging Exchange (AUSSIE): an innovative, virtually-integrated health research network embedded in health care

The Australian, US, Scandinavian Imaging Exchange (AUSSIE): an innovative, virtually-integrated health research network embedded in health care

Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease

Neuroimaging biomarkers differentiate Parkinson disease with and without cognitive impairment and dementia

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