The Subchronic Oral Toxicity of Ethane, 1,2-Bis(pentabromophenyl) (Saytex 8010) in Rats

Hardy, Marcia; Margitich, Dennis; Ackerman, Larry J.; Smith, Richard L.

doi:10.1080/10915810290096298

Cited by 41 publications

(31 citation statements)

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“…per day for 90 consecutive days (Hardy et al, 2002). Statistically significant differences were only found between control and female rats dosed 1 000 mg/kg b.w.…”

Section: Hazard Identificationmentioning

confidence: 87%

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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EFSA was asked to deliver a scientific opinion on brominated flame retardants (BFRs) other than PBDEs, PBBs, HBCDDs, TBBPA and brominated phenols and their derivatives. The BFRs that are the subject of the current opinion, were classified in groups termed "emerging" and "novel" BFRs. Information on 17 emerging and 10 novel BFRs was collected. The information varied widely for these BFRs. There is a lack of experimental data on physico-chemical characteristics, stability/reactivity and current use and production volume of all the emerging and novel BFRs. Due to the very limited information on occurrence, exposure and toxicity, the CONTAM Panel could not perform a risk characterisation for any of the BFRs considered. Instead, an attempt was made to identify those BFRs that could be a potential health concern and should be considered first for future investigations. For this purpose the Panel first evaluated the available experimental data on occurrence in food, behaviour in the environment and toxicity. Secondly, a modelling exercise was performed focussing on the potential of the emerging and novel BFRs for persistence in the environment and for their possible bioaccumulation potential. There is convincing evidence that tris(2,3-dibromopropyl) phosphate (TDBPP) and dibromoneopentyl glycol (DBNPG) are genotoxic and carcinogenic, warranting further surveillance of their occurrence in the environment and in food. Based on the limited experimental data on environmental behaviour, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and hexabromobenzene (HBB) were identified as compounds that could raise a concern for bioaccumulation. For the modelling exercise, the CONTAM Panel selected two environmental characteristics, overall persistence and potential for bioaccumulation, as being most relevant to provide insight into the possibility that emerging or novel BFRs The less well known and less studied BFRs, subject of the current opinion, were grouped into two classes, referred to herein as "emerging" and "novel" BFRs. Emerging BFRs are defined as chemicals which are applied as flame retardants and that have been identified in any environmental compartment, in wildlife, in food or in humans. It should be noted that the definition for the emerging BFRs, used in this opinion, does not imply that there is evidence for an increasing trend in the concentration of these BFRs in the environment, in food or in human samples. Novel BFRs are defined as chemicals applied as flame retardants, with confirmed presence in materials and/or goods in concentrations above 0.1 %, but not identified in environmental samples, wildlife, food or humans. In total, information on 27 BFRs, of which 17 were identified as "emerging" and 10 as "novel", was collected by the CONTAM Panel, and it was noted that the available information varied widely for the various individual BFRs.In general, there is a lack of experimental data on physico-chemical characteristics and stability/reactivity for all the emerging and novel BFRs. This sometimes hampered ...

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“…per day for 90 consecutive days (Hardy et al, 2002). Statistically significant differences were only found between control and female rats dosed 1 000 mg/kg b.w.…”

Section: Hazard Identificationmentioning

confidence: 87%

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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“…The occurrence of emerging pollutants such as BTBPE and DBDPE is also frequently reported in fish (Law et al, 2006;Wu et al, 2011), marine mammals (Tomy et al, 2007;Van Bavel et al, 2010), birds Verreault et al, 2007), and even human samples (Karlsson et al, 2007;Sjödin et al, 2003). However, bioaccumulation and toxicity data for higher-brominated PBDEs and novel flame retardants in chicken are still limited (Covaci et al, 2011;Egloff et al, 2011;Hardy et al, 2002).…”

Section: Introductionmentioning

confidence: 94%

Contaminant sources, gastrointestinal absorption, and tissue distribution of organohalogenated pollutants in chicken from an e-waste site

Zheng

Luo

Zheng

et al. 2015

Science of The Total Environment

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“…Previous disposition studies of DBDPE have focused on high dose exposures (Hardy et al, 2002, Hardy et al, 2010, Wang et al, 2010a). However, the effects seen at high doses may not accurately reflect disposition of DBDPE after much lower occupational or environmental exposures.…”

Section: Introductionmentioning

confidence: 99%

The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration

et al. 2016

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The disposition of decabromodiphenyl ethane (DBDPE) was investigated based on concerns over its structural similarities to decaBDE, high potential for environmental persistence & bioaccumulation, and high production volume.In the present study, female Sprague Dawley rats were administered a single dose of [14C]-DBDPE by oral, topical, or IV routes. Another set of rats were administered 10 daily oral doses of 14C]-DBDPE. Male B6C3F1/Tac mice were administered a single oral dose.DBDPE was poorly absorbed following oral dosing, with 95% of administered [14C]-radioactivity recovered in the feces, 1% recovered in the urine and less than 3% in the tissues at 72 h. DBDPE excretion was similar in male mice and female rats. Accumulation of [14C]-DBDPE was observed in liver and the adrenal gland after 10 daily oral doses.The dermis was a depot for dermally applied DBDPE; conservative estimates predict ~14±8% of DBDPE may be absorbed into human skin in vivo; ~7±4% of the parent chemical is expected to reach systemic circulation following continuous exposure (24 h).Following intravenous administration, 6% of the dose was recovered in urine and 28% in the feces, while ~70% of the dose remained in tissues after 72h, with the highest concentrations found in the liver (42%) and lung (17%).

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The Subchronic Oral Toxicity of Ethane, 1,2-Bis(pentabromophenyl) (Saytex 8010) in Rats

Cited by 41 publications

References 0 publications

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

Contaminant sources, gastrointestinal absorption, and tissue distribution of organohalogenated pollutants in chicken from an e-waste site

The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration

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