The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

Nozawa, Takashi; Minowa‐Nozawa, Atsuko; Aikawa, Chihiro; Nakagawa, Ichirô

doi:10.1080/15548627.2016.1241924

Cited by 40 publications

(24 citation statements)

References 39 publications

(47 reference statements)

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“…In addition, trafficking from early/recycling endosomes to the Golgi apparatus is mediated by complexing of VAMP3 with Stx16 (Qa), Vti1a (Qb), and Stx6 or Stx10 (Qc) (105,193,265), whereas trafficking in the reverse direction is mediated by complexing with Stx7 (Qa), Vti1b (Qb), and Stx6 (196,219,220). VAMP3 has also been described to mediate fusion between autophagosomes and multivesicular bodies to generate autophagosomal vacuoles called amphisomes (85), and this may play a role in the degradation of pathogen-containing endo/phagosomes (229).…”

Section: Vamp3mentioning

confidence: 99%

Endosomal and Phagosomal SNAREs

Dingjan

Linders

Verboogen

et al. 2018

Physiological Reviews

102

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The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport. In the endocytic route, SNARE proteins mediate trafficking between endosomes and phagosomes with other endosomes, lysosomes, the Golgi apparatus, the plasma membrane, and the endoplasmic reticulum. The goal of this review is to provide an overview of the SNAREs involved in endosomal and phagosomal trafficking. Of the 38 SNAREs present in humans, 30 have been identified at endosomes and/or phagosomes. Many of these SNAREs are targeted by viruses and intracellular pathogens, which thereby reroute intracellular transport for gaining access to nutrients, preventing their degradation, and avoiding their detection by the immune system. A fascinating picture is emerging of a complex transport network with multiple SNAREs being involved in consecutive trafficking routes.

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Section: Vamp3mentioning

confidence: 99%

Endosomal and Phagosomal SNAREs

Dingjan

Linders

Verboogen

et al. 2018

Physiological Reviews

102

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“…This pathway is activated when the constructive patterns of pathogen’s components are recognized (i.e., the cell wall components of a bacterial cell or the genome of a virus). Autophagy was initially thought to be a nonspecific mechanism for degrading substances by incorporating them into a membrane structure; however, recent studies have shown that autophagosomes selectively isolate a variety of substrates through sequestosome 1-like receptors, as is observed in autophagy of pathogens (xenophagy) [33,34,35]. Although the ubiquitin-proteasome system is a well-known selective intracellular degradation system, autophagy can selectively engulf and decompose small substances, such as mitochondria, which are larger than the targets of the ubiquitin-proteasome system, indicating characteristics similar to that of mitophagy [36,37].…”

Section: Role Of Autophagy In Innate Immunitymentioning

confidence: 99%

Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

Iida

Yokoyama

Wagatsuma

et al. 2018

Cells

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Autophagy, an intracellular degradation mechanism, has many immunological functions and is a constitutive process necessary for maintaining cellular homeostasis and organ structure. One of the functions of autophagy is to control the innate immune response. Many studies conducted in recent years have revealed the contribution of autophagy to the innate immune response, and relationships between this process and various diseases have been reported. Inflammatory bowel disease is an intractable disorder with unknown etiology; however, immunological abnormalities in the intestines are known to be involved in the pathology of inflammatory bowel disease, as is dysfunction of autophagy. In Crohn’s disease, many associations with autophagy-related genes, such as ATG16L1, IRGM, NOD2, and others, have been reported. Abnormalities in the ATG16L1 gene, in particular, have been reported to cause autophagic dysfunction, resulting in enhanced production of inflammatory cytokines by macrophages as well as abnormal function of Paneth cells, which are important in intestinal innate immunity. In this review, we provide an overview of the autophagy mechanism in innate immune cells in inflammatory bowel disease.

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“…complex; SNAREs are involved in autophagosome formation in response to bacterial infection [58]. SBDS encodes a highly conserved protein that related to primary immunode ciency and phagocyte defects.…”

Section: Role Of Candidate Genesmentioning

confidence: 99%

Genome-Wide Association Studies for Immunoglobulins in Colostrum and Serum in Chinese Holstein

Shan

Liu³

et al. 2020

Preprint

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Abstract BackgroundImmunoglobulins (Igs) are important components of the innate immune system, and fight pathogens as a part of the first defense line. Newborn dairy calves get maternal antibodies from colostrum. Therefore, contents of immunoglobulins in colostrum and serum of cows are essential traits when estimating potential natural disease resistance of calves. In this study, a genome-wide association study (GWAS) was performed to identify candidate genes that are responsible for the observed genetic variation of immunoglobulins contents in colostrum and blood in Holstein cows.ResultsColostrum, blood and hair follicle samples were collected from the 620 Chinese Holstein cows within 24 hours after calving. The concentration of IgG, IgG1, IgG2, IgA and IgM in both colostrum and serum were detected via ELISA methods, respectively. Using GCTA software, GWASs were performed with 88,934 SNPs genotyped by using Illumina 50K (54,609 SNPs) and GeneSeek 150K (140,668 SNPs) chips in which 50K chip were imputed to 150K SNPs with BEAGLE 3.0.4 software. As a result, 20 and 5 SNPs were detected genome-wide significantly associated with contents of the IgG and IgM in colostrum and serum (P<3.16E–6). In addition, 57, 11 and 10 SNPs were suggestive significantly associated with IgG, IgA and IgM traits (P<6.32E–5). Next, a total of 1,083 functional genes were identified that included or adjacent to these significant SNPs with a distance less than 1 Mb. Functional enrichment analysis showed that these genes were involved in immune related pathways, such as immune response, Fc gamma R-mediated phagocytosis, negative regulation of immunoglobulin secretion, humoral immune response, Fc-epsilon receptor and NF-kappaB signaling pathways. By integrating analysis of the functional enrichment and the known QTL data, we identified 21 candidate genes associated with contents of immunoglobulins in colostrum and serum, including ABR, TIMM22, CRK, MYO1C, RILP, SERPINF2, AKT1, BCL11B, HHIPL1, DYNC1H1, HSP90AA1, TRAF3, KLC1, IL6, PYCARD, ITGAM, TGFB1I1, GUSB, CRCP, RABGEF1 and SBDS.ConclusionsIn this study, we identified 21 candidate genes associated with immunoglobulins level in colostrum and serum in dairy cattle. This founding demonstrated the possibility of increasing immunity through selective breeding and provided an important information for molecular breeding of dairy cattle.

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The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

Cited by 40 publications

References 39 publications

Endosomal and Phagosomal SNAREs

Endosomal and Phagosomal SNAREs

Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

Genome-Wide Association Studies for Immunoglobulins in Colostrum and Serum in Chinese Holstein

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