The study of the quercetin action on human erythrocyte membranes

The ability of newly synthesized genistein benzyl and glycosylated derivatives to permeabilize the liposome membrane was studied by calcein-leakage method. All studied derivatives appeared to be more effective than their parent compound -genistein. Comparing the experimental results with theoretical calculations we found that in case of benzyl derivatives the dipole moment of added benzene ring (with its substitutions) might be important for the strength of flavonoids-lipid interactions. This conclusion may have some implications for QSAR studies in which mostly the dipole moments of entire molecules are considered.

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“…Such effects were found for erythrocyte membrane proteins [12,13] and also for gramicidin ion channels [14].…”

Section: Accepted M Manuscriptmentioning

confidence: 79%

Genistein derivatives decrease liposome membrane integrity — Calcein release and molecular modeling study

Środa

Michalak

Maniewska

et al. 2008

Biophysical Chemistry

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“…One of these flavonoids, quercetin (3,5,7,3', 4'-pentahydroxyflavone), has been reported to have the ability to prevent oxidant injury and cell death by scavenging free oxygen radicals [43]. Quercetin is widely distributed in fruits and vegetables such as onions, apples, berries, and tea [48]. Studies have shown that daily intake of quercetin may decrease the risks of cardiovascular diseases [39], tumour development, strokes and neurodegenerative diseases [53] by protection against oxidative DNA damage [21], lipid peroxidation [38] and inhibition of the release of inflammatory mediators [41].…”

Section: Introductionmentioning

confidence: 99%

Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats

Al-Kushi

ElSawy

2017

Folia Morphol

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“…Understanding the effects of CGA on the model lipid bilayer may help in explaining the molecular mechanism of the action of this polyphenol as an antioxidant [18][19][20][21][22][23]. The ability of polyphenols to penetrate into lipid bilayers is undoubtedly crucial to the protection against oxidation [24].…”

Section: Introductionmentioning

confidence: 99%

Effect of chlorogenic acid on the phase transition in phospholipid and phospholipid/cholesterol membranes

Pruchnik

Bonarska-Kujawa

Kleszczyńska

2014

J Therm Anal Calorim

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Chlorogenic acid (CGA) is present in many plants, especially in green coffee, dry plums, and bilberries. It is an important bioactive polyphenol. Studies showed that CGA has an antioxidative, bacteriostatic, anticancer, antiviral, and anti-inflammatory activity. Despite great interest in this compound, its interaction with the lipid model membrane has not yet been investigated. To better understand the relationship between the biological activity of CGA and its interaction with biological membranes, the thermotropic behavior of model lipid membranes was investigated. The effect of CGA on the model lipid membrane, specifically on the lipid bilayer phase transitions, was examined by the combined methods: differential scanning calorimetry and fluorescence spectroscopy. In particular, the degree of packing order of the hydrophilic phase of the lipid bilayer was determined using the fluorimetric method with Laurdan and Prodan probes, while the fluorescence anisotropy of the hydrophobic phase with the DPH and TMA-DPH probes. The results of the study show that CGA incorporates mainly into the hydrophilic part of membrane, changing the packing order of the polar heads of lipids. No significant changes were recorded in membrane fluidity of the hydrophobic membrane region, for the fluorescence anisotropy practically did not change. One can thus infer that CGA does not penetrate deep into the hydrophobic area of the membrane.

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The study of the quercetin action on human erythrocyte membranes

Cited by 117 publications

References 25 publications

Genistein derivatives decrease liposome membrane integrity — Calcein release and molecular modeling study

Genistein derivatives decrease liposome membrane integrity — Calcein release and molecular modeling study

Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats

Effect of chlorogenic acid on the phase transition in phospholipid and phospholipid/cholesterol membranes

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