The study of the photokilling effect and mechanism of ultrafine TiO2 particles on U937 cells

Huang, Ning‐Ping; Xu, Min; Yuan, Chris; Rui-rong, Yu

doi:10.1016/s1010-6030(97)00093-2

Cited by 80 publications

(27 citation statements)

References 9 publications

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“…1,17 In case of TiAg alloys, germ counts decreased rapidly in the initial 20 minutes. The primary step in photocatalytic decomposition consists of hydroxyl radical attack on the cell wall.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that the antibacterial effect of TiO 2 is based on the disorder of the cytoplasmic membrane. 1,6,17 The photocatalytic ability is lost if the electronic hole pairs of TiO 2 recombine before they can be used for photocatalysis. The high levels of antibacterial efficiency of TiAg compared with that of Ti may be explained by the role of Ag in preventing the recombination of electrons and holes, which in turn, facilitates disruption of the cell wall.…”

Section: Discussionmentioning

confidence: 99%

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Photocatalytic Antibacterial Effect of TiO2 Film of TiAg on Streptococcus mutans

Choi

Chung

Oh³

et al. 2009

The Angle Orthodontist

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Objective: To test through various oxidation procedures the differences in antibacterial activities against Streptococcus mutans (S mutans) of Titanium (Ti) and Titanium silver (TiAg) metals coated with TiO 2 . Materials and Methods: This study examined the photocatalytic antibacterial effects on S mutans of Ti and TiAg ubstrates coated with two crystalline forms of TiO 2 by thermal and anodic oxidation. A bacterial suspension of S mutans was pipetted onto TiO 2 -coated metal specimens and uncoated specimens with ultraviolet A (UVA) illumination for 20 to 100 minutes. The same specimen without UVA was used as the control. The level of colony-forming units of S mutans after UVA illumination was compared with that of the control. Results: The level of colony-forming units of S mutans was significantly lower on TiO 2 -coated Ti and TiAg metal specimens after UVA illumination than on uncoated Ti and TiAg specimens. The level of colony-forming units of S mutans was significantly lower on the metals coated by anodic oxidation than on those coated by thermal oxidation. The TiO 2 coating on TiAg had a significantly higher and more rapid antibacterial effect than did the TiO 2 coating on Ti. Conclusions:The antibacterial effect of a TiO 2 film formed by anodic oxidation was superior to that formed by thermal oxidation. The addition of Ag to the Ti specimen indicated a synergistic effect on the photocatalytic antibacterial property against S mutans. (Angle Orthod. 2009;79: 528-532.)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Photocatalytic Antibacterial Effect of TiO2 Film of TiAg on Streptococcus mutans

Choi

Chung

Oh³

et al. 2009

The Angle Orthodontist

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“…Interestingly, the photocatalytic properties of TiO 2 − mediated toxicity have been shown to eradicate cancer cells [16][17]. It is now well established that TiO 2 particles, on exposure to UV light, produce electrons and holes leading subsequently to the formation of reactive oxygen species such as hydrogen peroxide, hydroxyl radicals, and superoxides [18].…”

Section: Introductionmentioning

confidence: 99%

Surface chemistry influences cancer killing effect of TiO2 nanoparticles

Thevenot¹,

Cho²,

Wavhal³

et al. 2008

Nanomedicine: Nanotechnology, Biology and Medicine

205

113

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Photocatalyzed TiO 2 nanoparticles have been shown to eradicate cancer cells. However the required in situ introduction of UV light limits the use of such a therapy in patients. In the present study, the non-photocatalyic anti-cancer effect of surface functionalized TiO 2 was examined. Nanoparticles bearing -OH, -NH2, or -COOH surface groups, were tested for their effect on in vitro survival of several cancer and control cell lines. The cells tested included B16F10 melanoma, Lewis lung carcinoma (LLC), JHU prostate cancer cells, and 3T3 fibroblasts. Cell viability was observed to depend on particle concentrations, cell types, and surface chemistry. Specifically, -NH 2 and -OH groups exhibited significantly higher toxicity than -COOH. Microscopic and spectrophotometric studies revealed nanoparticle-mediated cell membrane disruption leading to cell death. The results suggest that functionalized TiO 2 , and presumably other nanoparticles, may be surface engineered for targeted cancer therapy.

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“…Foi descoberto que, por fotocatálise heterogênea, o TiO 2 é efetivo em sistemas bioquímicos para destruir células malígnas. [15][16][17] Desta forma, o uso de UV/TiO 2 aparece como uma técnica muito promissora, porque: (a) evita a formação de compostos halogenados, que podem ser perigosos para os seres humanos; (b) não é uma técnica cara; e (c) parece atuar sobre todos os tipos de bactérias, incluindo gram (+) e (-), e sobre outros micro-organismos. 18 O fotocatalizador é abundante, barato e de fácil recuperação ou pode ser imobilizado sobre suportes adequados.…”

Section: Desinfecção Da áGua Utilizando Fotocatálise Heterogêneaunclassified

Application of Advanced Oxidation Methods for Water Disinfection

Brito¹,

Araújo²,

Martínez‐Huitle³

2015

Revista Virtual De Química

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Abstract:Chlorination is the most used method in the world for drinking water disinfection. However, the identification of by-products potentially toxics generated by this method has encouraged the development of new alternative disinfection technologies. Among them, heterogeneous photocatalysis, TiO 2 photocatalysis and electrochemical disinfection are considered as suitable alternatives to replace the chlorination method. This review article gives a general overview about these treatment systems that can contribute to drinking water disinfection and it shows the efficiency of recently developed free-chlorine systems.Keywords: Disinfection water; electrochemistry; photochemistry; chlorination; microorganisms. ResumoA cloração é o método mais usado no mundo para a desinfecção de água potável. No entanto, a identificação de subprodutos potencialmente tóxicos gerados por este método tem estimulado o desenvolvimento de novas tecnologias alternativas de desinfecção. Entre elas, fotocatálise heterogênea, fotocatálise de TiO 2 e desinfecção eletroquímica são consideradas alternativas adequadas para substituir o método de cloração. Este artigo de revisão dá uma visão geral sobre estes sistemas de tratamento eletroquímico que podem contribuir para a desinfecção de água potável o que mostra eficiência dos sistemas livres de cloro recentemente desenvolvidos.

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The study of the photokilling effect and mechanism of ultrafine TiO2 particles on U937 cells

Cited by 80 publications

References 9 publications

Photocatalytic Antibacterial Effect of TiO2 Film of TiAg on Streptococcus mutans

Photocatalytic Antibacterial Effect of TiO2 Film of TiAg on Streptococcus mutans

Surface chemistry influences cancer killing effect of TiO2 nanoparticles

Application of Advanced Oxidation Methods for Water Disinfection

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