The Study of the Inhibition Effects of Satureja khuzestaniea Essence on the Gene Expression of bla-^OXA-23 in Multidrug-Resistant Strains of Acinetobacter baumannii

Abstract

Background: Acinetobacter baumannii is one of the Gram-negative bacteria in nosocomial infections that is resistant to treatment and control. The isolation of these bacteria is increasing significantly throughout the world. With increasing populations and a reduction in the use of synthetic drugs, many of these medicinal herbs are replacing other treatments. Objectives: The present study aims to investigate the inhibitory effects of Satureja khuzestaniea essence on the expression of the antibiotic resistance genes bla-OXA-23 and Housekeeping DNA gyrase-A in multidrug-resistant strains of Acinetobacter baumannii, using

In-Vitro Antimicrobial Activity and Chemical Composition of Satureja khuzestanica Jamzad Essential Oils Against Multidrug-Resistant Acinetobacter baumannii

“…In literature search, recent report showing that the antibacterial activity of S. khuzistanica essential oil against A. baumannii was related to reduce the bap gene that involved in biofilm formation by the organism (17). Another recent study showed that Satureja khuzestanica Jamzad EO has inhibitory effects on the expression of bla OXA-23 gene in drug-resistant A. baumannii (18). We believe that our results present the first report on the susceptibility of drug-resistant A. baumannii nosocomial strains to S. khuzistanica EO.…”

“…Other recent studies have been shown that carvacrol-rich S. khuzestanica EO has antimicrobial activity against clinical urinary isolates of E. coli, a number of Gram-positive cocci and yeast strains (15,16). Also the effect of S. khuzestanica EO has been shown on the expression of the bap gene which is involved in biofilm formation and bla gene in antibiotic resistant A. baumannii using polymerase chain reaction (17,18).…”