The Study of the Fixed Dose Combination of Lisinopril with Prolonged Indopamide (FIXLINDA) with Daily Blood Pressure Monitoring and Diuresis in Hypertensive Patients

Abstract

Аim. To study the efficacy, tolerability and safety of using a fixed dose combination of an ACE inhibitor lisinopril with a prolonged-action diuretic indapamide in patients with degree 1-2 hypertension.Material and methods. Patients (n = 32) with uncontrolled 1-2 degrees hypertension, moderate or high cardiovascular risk, without severe comorbid diseases, who were prescribed a fixed dose combination of lisinopril (5, 10 or 20 mg) and indapamide (1.5 mg) were included in the observational study. All patients had home monitoring of blood pressure and diuresis, as well as assessment of subjective tolerance of treatment and registration of adverse events within 3 months of observation. Assessment of changes in circadian fluctuations in blood pressure and diuresis, the frequency of achieving the target blood pressure at the outpatient stage, as well as the subjective tolerance of treatment and adverse events during a three-month follow-up.Results. Target blood pressure was achieved in 44.5% of patients taking the fixed dose combination of lisinopril 5 mg + prolonged-acting indapamide1.5 mg; 76.9% – in patients taking the combination of lisinopril 10 mg + indapamide 1.5 mg; 78,6% – in patients taking the combination of lisinopril 20 mg + indapamide 1.5 mg. The achieved antihypertensive effect was characterized by daily circadian stability, accompanied by an improvement in the initially impaired day and night diuretic profile (increase in the share of daytime diuresis by 29.6% and 22.3% with a decrease in the share of nighttime diuresis by 35% and 49% when using a combination with lisinopril 5 and 10 mg, respectively). The treatment was well tolerated by patients and did not cause the development of serious adverse events. Reported adverse events (non-intense dry cough, headache, general weakness) were transient and did not require correction or withdrawal of treatment.Conclusion. The fixed dose combination of the ACE inhibitor lisinopril (5, 10 or 20 mg) and the long-acting thiazide-like diuretic indapamide (1.5 mg) had good antihypertensive efficacy with improved circadian blood pressure and diuresis profiles, acceptable tolerance and safety of treatment, as well as a simple choice of doses of the drug components.

Tactics of antihypertensive therapy during COVID-19 pandemic

“…В свою очередь, лизиноприл начинает действовать через 1-3 ч после приема, достигает пика концентрации через 6 ч и сохраняет адекватную для контроля АД концентрацию на протяжении 24 ч, что обеспечивает длительный период полувыведения 12,6 ч. Таким образом, оба препарата, входящие в состав данной комбинации, обладают длительным взаимодополняющим действием, обеспечивающим надежный суточный контроль АД (рис. 3), что подтверждено результатами отечественного исследования ФИКСЛИНДА [47].…”

Strategies for choosing combination therapy for hypertension in metabolic syndrome - focus on inflammation

“…В исследовании фиксированной комбинации ингибитора АПФ лизиноприла и диуретика индапамида пролонгированного действия (ФИКСЛИНДА) доказано, что эта комбинация обладает высокой эффективностью для лечения АГ и сопровождалось стабильным терапевтическим эффектом с достаточно высокой частотой достижения целевого АД и уменьшением его циркадных колебаний у пациентов с АГ 1-2 степени при хорошей переносимости лечения [37].…”