Islamic liberation theology emphasizes the importance of man's role as a caliph, who is God's representation on earth. This research seeks to understand the paradigm of human responsibility as a caliph in Islamic liberation. The method used in this research is a literature study. Data collection techniques used in this research were obtained from books, academic journals, the Qur'an and other articles relevant to the research problem. The data analysis technique used is the analysis and interpretation of the data obtained. The results of the study explain that the responsibility of human 'Khalifah' in liberation is very large; as a representation of God who is given the ability to think, humans are explained to be emancipatory entities over the chaotic condition of the earth. Realizing liberation in Islam is explained as a form of unity with God; divine affairs are not only matters of transcendental worship but also relate to harmony of human relations with other humans and also nature, and ultimately with liberation as a form of implementing God's orders. Islam explains the importance of liberation with the presence of the Qur'an, which is taught to liberate man from his condition.