The Study of Prevalence and Pattern of Thyroid Disorder in Pregnant Women: A Prospective Study

Gupta, Preeti; Jain, Manila; Verma, Vandana; Gupta, Nitin

doi:10.7759/cureus.16457

Cited by 11 publications

(13 citation statements)

References 26 publications

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“…The prevalence of hypothyroidism in our study population is similar to the reports from other low to middle-income settings [ 13 , 15 - 17 ]. A higher prevalence (16%) was however reported in Nigeria by Abdulslam K et al .…”

Section: Discussionsupporting

confidence: 90%

“…The prevalence of hypothyroidism in pregnancy varies across different ethnic groups [ 10 ]. In a low to middle-income setting, the prevalence is reported between 5 - 18% [ 11 - 13 ]. Although subclinical hypothyroidism is more prevalent than overt hypothyroidism in pregnancy, studies still report poor neurologic development in children born to mothers with any form of hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and correlates of hypothyroidism in pregnancy: a cross-sectional study at Bouget General Hospital, Ivory Coast

Adoueni¹,

Azoh²,

Kouame³

et al. 2022

Pan Afr Med J

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Introduction several adverse pregnancy outcomes have been reported in gestations with associated hypothyroidism. The prevalence of hypothyroidism has not been frequently reported in Black Africans. This study sorts to report the prevalence and associated factors of hypothyroidism in Black African pregnant women. Methods this was a hospital-based cross-sectional study, including all pregnant women attending the gynecologic unit of Bouget General Hospital Abidjan. Serum thyroid-stimulating hormone and T4 were obtained from all participants and analyzed using a fluorescent Immunochemistry assay. Data were analyzed using R version 4.05. Univariable and multivariable logistic regression was used to assess factors associated with hypothyroidism and statistical significance considered as p < 0.05. Results overall there were 693 participants, mean age of 28.1(SD 6.4) years with an average gestational age of 24.1 (SD 8) weeks, and a majority of study participants were in the second trimester of gestation. The prevalence of hypothyroidism was 12.1% (n = 84) (10.8% subclinical hypothyroidism and 1.3% clinical hypothyroidism) whereas 1.9% (n = 13) had hyperthyroidism. In addition, patients with reported type 1 diabetes mellitus had an increased risk of hypothyroidism (aOR: 12.6, 95% CI 1.9-100.8; p ≤ 0.01). Conclusion this study revealed a high prevalence of hypothyroidism, though mostly in the subclinical form. Further research is warranted to confirm these findings which may have implications on early screening of hypothyroidism in black African women.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of hypothyroidism in pregnancy: a cross-sectional study at Bouget General Hospital, Ivory Coast

Adoueni¹,

Azoh²,

Kouame³

et al. 2022

Pan Afr Med J

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“…Ajmani et al(29), where it was observed that the higher the BMI was associated with this disease. Furthermore, the study conducted by P. Gupta et al (30) showed that high BMI were related with both hypothyroidism and hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, risk factors, and consequences of hypothyroidism among pregnant women in the health region of Lleida: a cohort study

Siscart

Perejón

Serna

et al. 2022

Preprint

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Background: Primary maternal hypothyroidism is defined as the increase of TSH levels in serum during pregnancy. Hypothyroidism in pregnancy is the second most common endocrine disease, after diabetes mellitus, with a prevalence ranging between 3.2 and 5.5%. Its variability depends on ethnical differences. Hypothyroidism in pregnancy is associated with other chronic diseases and fetal and maternal outcomes. Objective: To analyze the prevalence of hypothyroidism among multiethnic pregnant women, and to evaluate the comorbidity with chronic diseases and outcomes leaded during pregnancy and newborn. Methods: Retrospective observational cohort study in pregnant women during the years 2012- 2018 in the health region of Lleida. The relationship of hypothyroidism with different variables was analyzed by calculating the adjusted odds ratio (aOR) and the 95% confidence intervals (CI) with multivariate logistic regression models. Results: We analyzed a sample of 17177 pregnant women, which represents more than 92% of the total of pregnant women in the health region of Lleida. The annual prevalence of hypothyroidism was 5.7-7.1%. According to the region of origin, the lowest prevalence was found in the population from Sub Saharian Africa (2.1%), while the highest was from Asia and the Middle East (8.6%). Other factors associated with hypothyroidism were age, hypertension, diabetes mellitus, and dyslipidemia. In addition, we did not observe an effect of hypothyroidism on the course of pregnancy, childbirth, and on the newborn. Finally, there was a good control of the disease during pregnancy. Conclusions: The prevalence of hypothyroidism in pregnancy was 6,5% in this study which depends on the country of origin, lower values were found in Sub Saharian African women and higher in those from Asia and the Middle East. Hypothyroidism was associated with age, diabetes mellitus, arterial hypertension, or dyslipidemia, and was not related to the Apgar score or the weight of the newborn.

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“…Importantly, thyroid disorders are common during pregnancy ( 8 ). The prevalence of hypothyroidism during pregnancy varies between 2.5% and 11% ( 9 ). The main cause of thyroid disorders is iodine malnutrition (iodine deficiency or excess).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases

Mendoza-León,

Mangalam,

Regaldiz

et al. 2023

Front. Endocrinol.

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Thyroid disorders are clinically characterized by alterations of L-3,5,3’,5’-tetraiodothyronine (T4), L-3,5,3’-triiodothyronine (T3), and/or thyroid-stimulating hormone (TSH) levels in the blood. The most frequent thyroid disorders are hypothyroidism, hyperthyroidism, and hypothyroxinemia. These conditions affect cell differentiation, function, and metabolism. It has been reported that 40% of the world’s population suffers from some type of thyroid disorder and that several factors increase susceptibility to these diseases. Among them are iodine intake, environmental contamination, smoking, certain drugs, and genetic factors. Recently, the intestinal microbiota, composed of more than trillions of microbes, has emerged as a critical player in human health, and dysbiosis has been linked to thyroid diseases. The intestinal microbiota can affect host physiology by producing metabolites derived from dietary fiber, such as short-chain fatty acids (SCFAs). SCFAs have local actions in the intestine and can affect the central nervous system and immune system. Modulation of SCFAs-producing bacteria has also been connected to metabolic diseases, such as obesity and diabetes. In this review, we discuss how alterations in the production of SCFAs due to dysbiosis in patients could be related to thyroid disorders. The studies reviewed here may be of significant interest to endocrinology researchers and medical practitioners.

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The Study of Prevalence and Pattern of Thyroid Disorder in Pregnant Women: A Prospective Study

Cited by 11 publications

References 26 publications

Prevalence and correlates of hypothyroidism in pregnancy: a cross-sectional study at Bouget General Hospital, Ivory Coast

Prevalence and correlates of hypothyroidism in pregnancy: a cross-sectional study at Bouget General Hospital, Ivory Coast

Prevalence, risk factors, and consequences of hypothyroidism among pregnant women in the health region of Lleida: a cohort study

Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases

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