The Study of Peripheral Blood Mononuclear Cell MHC I and MHC II Gene mRNA Expression in Acute Graft Rejection

Li, X.-D.; Zou, Xiong; Zhang, Y.; Lü, Nan; Wan, Furong; Zhao, Sixiang; Li, X.-L.; Jiang, Hong

doi:10.1016/j.transproceed.2006.08.185

Cited by 1 publication

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“…This is similar to the trend in the expression of MHC-I mRNA seen previously. 18,24 In addition, increased levels of HLA-I antigens on peripheral blood lymphocytes have been reported in liver transplant rejection 25 and cardiac transplant rejection. 26 This suggests that MHC-I antigen upregulation on peripheral CD3 + CD8 + T-cells is a universal characteristic of organ transplantation rejection.…”

Section: Discussionmentioning

confidence: 99%

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3⁺CD8⁺ T-Lymphocytes following Skin Transplantation in Mice

et al. 2011

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This study investigated major histocompatibility complex class I (MHC-I) antigen expression on peripheral blood T-cells after transplantation to assess its potential as an early marker of acute graft rejection (AGR). Using a mouse model with or without immunosuppressive treatment, the expression of MHC-I antigens on CD3(+)CD8(+) T-lymphocytes was assessed by flow cytometry following syngeneic graft (n = 138) or allograft (n = 138) skin transplantation. The occurrence of AGR was assessed by examining the degree of lymphocyte and monocyte infiltration in transplant biopsies. During AGR, expression of MHC-I antigens increased significantly compared with pre-transplant levels in the allograft group, even with immunosuppressive treatment. The highest expression of MHC-I antigens occurred 5 - 6 days before macroscopic rejection. These results suggest that expression of MHC-I antigens on peripheral blood CD3(+)CD8(+) T-lymphocytes could be used as an early marker for predicting AGR.

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Section: Discussionmentioning

confidence: 99%

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3⁺CD8⁺ T-Lymphocytes following Skin Transplantation in Mice

et al. 2011

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The Study of Peripheral Blood Mononuclear Cell MHC I and MHC II Gene mRNA Expression in Acute Graft Rejection

Cited by 1 publication

References 6 publications

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3⁺CD8⁺ T-Lymphocytes following Skin Transplantation in Mice

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3⁺CD8⁺ T-Lymphocytes following Skin Transplantation in Mice

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The Study of Peripheral Blood Mononuclear Cell MHC I and MHC II Gene mRNA Expression in Acute Graft Rejection

Cited by 1 publication

References 6 publications

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3+CD8+ T-Lymphocytes following Skin Transplantation in Mice

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3+CD8+ T-Lymphocytes following Skin Transplantation in Mice

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Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3⁺CD8⁺ T-Lymphocytes following Skin Transplantation in Mice

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3⁺CD8⁺ T-Lymphocytes following Skin Transplantation in Mice