The Study of Mental and Resistance Training (SMART) Study—Resistance Training and/or Cognitive Training in Mild Cognitive Impairment: A Randomized, Double-Blind, Double-Sham Controlled Trial

Singh, Maria A. Fiatarone; Gates, Nicola; Saigal, Nidhi; Wilson, Guy C; Meiklejohn, Jacinda; Brodaty, Henry; Wang, Wen; Singh, Nalin; Baune, Bernhard T.; Suo, Chao; Baker, Michael K.; Foroughi, Nasim; Wang, Yichuan; Sachdev, Perminder S.; Valenzuela, Michael

doi:10.1016/j.jamda.2014.09.010

Cited by 337 publications

(275 citation statements)

References 34 publications

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“…Of these, six were computerized interventions, 14 were therapist-based interventions, and 10 multimodal studies. In the multimodal studies, cognitive outcomes compared to a control group could be extracted from one additional computerized (Fiatarone Singh et al 2014) and two additional therapist-based interventions (Lam et al 2015; Nakatsuka et al 2015). Thus, aspects of these studies appear in both analyses: the isolated cognitive intervention outcomes in the respective computerized or therapist-based intervention sections, and the cognitive intervention outcomes when combined with other nonpharmacological interventions in the multi-modal section.…”

Section: Resultsmentioning

confidence: 99%

“…Sample sizes ranged from 8 to 51 (M = 21.3, SD = 15.2) and 7 to 49 (M = 17.7, SD = 14.7) for the intervention group (IG) and the control groups (CG) respectively, based upon numbers at final follow-up. One study (Fiatarone Singh et al 2014) was a clear outlier with the 51 and 49 participants in the IG and CG groups. Excluding that study, the mean across studies for IG was 16.3 (SD = 8.5) and CG was 12.5 (SD = 5.6).…”

Section: Resultsmentioning

confidence: 99%

“…For those studies utilizing some approximation of CONSORT reporting guidelines (Schulz et al 2010) recruitment rates ranges from 4.5 % (Fiatarone Singh et al 2014; Hughes et al 2014) for community samples to 33 % (Gagnon and Belleville 2012) for a clinical sample (M = 37.8; SD = 36.8). Pooled (intervention and control) retention rates ranged from 64 % (Maurice Finn and McDonald 2011) to 100 % (Hughes et al; M = 86.3; SD = 35.1).…”

Section: Resultsmentioning

confidence: 99%

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Everyday Impact of Cognitive Interventions in Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

et al. 2016

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Cognitive interventions in Mild Cognitive Impairment (MCI) seek to ameliorate cognitive symptoms in the condition. Cognitive interventions may or may not generalize beyond cognitive outcomes to everyday life. This systematic review and meta-analysis sought to assess the effect of cognitive interventions compared to a control group in MCI on generalizability outcome measures [activities of daily living (ADLs), mood, quality of life (QOL), and metacognition] rather than cognitive outcomes alone. PRISMA guidelines were followed. MEDLINE and PsychInfo were utilized as data sources to locate references related to cognitive interventions in individuals with MCI. The cognitive intervention study was required to have a control or alternative treatment comparison group to be included. Thirty articles met criteria, including six computerized cognitive interventions, 14 therapist-based interventions, and 10 multimodal (i.e., cognitive intervention plus an additional intervention) studies. Small, but significant overall median effects were seen for ADLs (d = 0.23), mood (d = 0.16), and metacognitive outcomes (d = 0.30), but not for QOL (d = 0.10). Computerized studies appeared to benefit mood (depression, anxiety, and apathy) compared to controls, while therapist-based interventions and multimodal interventions had more impact on ADLs and metacognitive outcomes than control conditions. The results are encouraging that cognitive interventions in MCI may impact everyday life, but considerably more research is needed. The current review and meta-analysis is limited by our use of only PsychInfo and MEDLINE databases, our inability to read full text non-English articles, and our reliance on only published data to complete effect sizes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Everyday Impact of Cognitive Interventions in Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

et al. 2016

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“…According to systematic reviews exercise interventions enhance mobility (Pitkälä, Savikko, Pöysti, Strandberg, & Laakkonen, 2013) and may improve the ability to perform activities of daily living (Forbes, Forbes, Blake, Thiessen, & Forbes, 2015) among people with dementia. In recently published RCT high intensity supervised progressive resistance training improved cognition among participants with mild cognitive impairment (Fiatarone Singh et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Health condition and physical function as predictors of adherence in long-term strength and balance training among community-dwelling older adults

Aartolahti

Tolppanen

Lönnroos

et al. 2015

Archives of Gerontology and Geriatrics

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“…113 In a study of resistance training in persons with MCI, there was a significant improvement in global cognitive function and maintenance of executive function over 18 months. 114 In the Fitness for Aging Brain study, physical activity enhanced cognitive scores, compared with an educational program over the 18-month follow-up. 115 A meta-analysis of 2533 participants found that Tai Chi enhanced both executive function and global cognitive function.…”

Section: Potential Benefits Of Early Diagnosis Of Cognitive Impairmentmentioning

confidence: 99%

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Morley

Morris²,

Berg‐Weger

et al. 2015

Journal of the American Medical Directors Association

244

163

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Cognitive impairment creates significant challenges for patients, their families and friends, and clinicians who provide their health care. Early recognition allows for diagnosis and appropriate treatment, education, psychosocial support, and engagement in shared decision-making regarding life planning, health care, involvement in research, and financial matters. An IAGG-GARN consensus panel examined the importance of early recognition of impaired cognitive health. Their major conclusion was that case-finding by physicians and health professionals is an important step toward enhancing brain health for aging populations throughout the world. This conclusion is in keeping with the position of the United States’ Centers for Medicare and Medicaid Services that reimburses for detection of cognitive impairment as part the of Medicare Annual Wellness Visit and with the international call for early detection of cognitive impairment as a patient’s right. The panel agreed on the following specific findings: (1) validated screening tests are available that take 3 to 7 minutes to administer; (2) a combination of patient- and informant-based screens is the most appropriate approach for identifying early cognitive impairment; (3) early cognitive impairment may have treatable components; and (4) emerging data support a combination of medical and lifestyle interventions as a potential way to delay or reduce cognitive decline.

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The Study of Mental and Resistance Training (SMART) Study—Resistance Training and/or Cognitive Training in Mild Cognitive Impairment: A Randomized, Double-Blind, Double-Sham Controlled Trial

Cited by 337 publications

References 34 publications

Everyday Impact of Cognitive Interventions in Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

Everyday Impact of Cognitive Interventions in Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

Health condition and physical function as predictors of adherence in long-term strength and balance training among community-dwelling older adults

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

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