Depression is a major mental health problem that is becoming a great concern among adolescents. An adolescent who experiences depression is associated with having internet addiction and Fear of Missing Out (FoMO). The study aims to i) identify the correlation between internet addiction and FoMO and depression, as well as ii) to determine the predictive effects of internet addiction and FoMO on the depression of rural secondary school students. This quantitative approach study utilises the online questionnaire method (via Google Form) which was participated by 145 Form 4 students. A descriptive analysis of the Pearson Correlation and regression was conducted using the 25.0 version of Statistical Package for Social Sciences (SPSS) software. The results indicated that internet addiction and FoMO have significant positive correlation with depression. Internet addiction and FoMO have positive predictive effects on depression of rural secondary school students. The implication of this study holds crucial importance in understanding the correlation between internet addiction and FoMO with depression, as well as the necessity for intervention that can be designed in order to assist the treatment of students who face the problems of internet addiction, FoMO and depression. The recommendation for future researchers is to further explore and expand the research via a mixed-method in order to gain more transparent and accurate results based on respondents' experiences.