The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity

Abstract

Interleukin-17 has a role in the pathogenesis of VKC and also has been proven in the former studies.

Conjunctival transcriptome analysis reveals the overexpression of multiple pattern recognition receptors in vernal keratoconjunctivitis

“…Several genes included in the Th17-differentiation family were also overexpressed in VKC. Increased serum and tears levels of IL-17 have been reported in VKC [25,26]. Considering also that we previously found Th17-cells in VKC tears (unpublished data) our hypothesis is that a subpopulation of VKC patients may be driven by a Th17-response or that Th2 and Th17 inflammatory pathways are mutually regulated in VKC as suggested in asthmatic patients [27].…”

Vernal Keratoconjunctivitis: an update focused on clinical grading system

“…We studied the production of IL-17 in a limited number of VKC children and found that serum level of IL-17 was significantly higher respect to the healthy controls although it did not correlate with clinical grading of severity [37]. A subsequent study confirmed our results in larger VKC population and showed, unlike our results, that the levels of IL-17 correlated with the severity, in particular with the presence and size of Trantas dots [38].…”

Ocular allergy as a risk factor for dry eye in adults and children

“…The role of Th17 in ocular allergy is controversial. Some researches reported preliminary data suggesting increased tear levels of IL-17 in VKC [29] and in SAC and PAC [30]. However this does not directly point to a role for Th17 cells as other cells, innate immune cells, are also IL-17…”