The study of inhibition of DNA synthesis by hydroxyurea(s)

Abstract

A novel method for the study of inhibition of DNA synthesis by hydroxyurea(s) using topological indices and frontier molecular orbital energies: Ehom,,, Elum,, and Et,,t~l is described. The data suggest that the inhibitory activities of urea(s) can be successfully modelled by these molecular descriptors. Excellent results are obtained in multivariate systems as well as upon introducing a dummy parameter.