The study of influence of a rotating magnetic field on mixing efficiency

The Effect of Rotating Magnetic Field on Susceptibility Profile of Methicillin-Resistant Staphylococcus aureus Strains Exposed to Activity of Different Groups of Antibiotics

“…Therefore, it was possible to try to determine the impact of another variable on the observed changes (being a result of RMF activity), namely anionic, cationic, or zwitterionic character of the antimicrobials. Numerous literature data [ 36 , 37 ], as well as the previous experience of our research group [ 16 ], indicated that RMF influence was related to its interactions with electrically charged molecules. Therefore, it was expected that the charge of individual antibiotics may be of significance, especially taking into account the process of their diffusion in the microbiological medium.…”

“…The next line of investigation was performed to analyze another crucial variable in the applied experimental system, namely the differences in antibiotics’ release and diffusion, which may potentially occur between bacterial cultures exposed and unexposed to the RMF. Considering our previously published data regarding, e.g., mixing efficiency under the influence of the RMF [ 16 , 51 ], it can be noticed that MF influence was related to its interactions with electrically charged molecules. Therefore, we aimed to investigate whether magnetic exposure alters the release of the antibiotics from the paper discs and their diffusion in the agar medium.…”

“…In our previous works, we have showed that, in the case of RMF, opposite poles rotate around a certain point; therefore, the charged molecules (e.g., antibiotics) present in a medium move in an unpredictable, Brownian-type motion. Therefore, one of the results of RMF application is high mixing of the medium due to increased particle movement [ 16 ]. Moreover, in our earlier publication [ 10 ], we indicated that the combined effect of RMF and antimicrobials increases the eradication rate of S. aureus biofilm to 50% as compared to biofilms exposed to antimicrobials only.…”

Application of Rotating Magnetic Fields Increase the Activity of Antimicrobials Against Wound Biofilm Pathogens

“…Also, because opposite poles rotate around a certain point, the charged molecules present in a medium will move in an unpredictable, Brownian-type motion. Indeed, one of the RMF application results is high mixing of medium, increased oxygenation and temperature rise (in our experimental setting temperature was kept at constant level of 37 °C by external coolers) due to increased particle movement 30 , 31 …”

Rotating Magnetic Field Increases β-Lactam Antibiotic Susceptibility of Methicillin-Resistant Staphylococcus aureus Strains

“…amoxicillin) bind better to PBP2a than cephalosporins. The size of the particles of individual antibiotics, as well as their charge, may also be important, especially taking into account the possible effects of the MF on charged particles, and thus on the process of their diffusion in the microbiological medium [62,63]. Our findings showed that an increase in antibiotic susceptibility in all RMF-exposed cultures was obtained for seven out of the eleven β-lactam antibiotics included in the experiment (Table 3, Figure 2, Supplementary Figure S4).…”